The Complement Cascade The Terminal Pathway. Complement: The Terminal Pathway C3b C3b is the first component of the Terminal Pathway C3a C3.

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Presentation transcript:

The Complement Cascade The Terminal Pathway

Complement: The Terminal Pathway C3b C3b is the first component of the Terminal Pathway C3a C3

Complement: The Terminal Pathway C5 C3b C3b cleaves C5 C5b C5a producing C5a and C5b Next

Complement: The Terminal Pathway C6 C5b binds to C6 C5b

Complement: The Terminal Pathway C5b binds to C6 Next C5b.6

Complement: The Terminal Pathway C7 C5b.6 binds to C7 C5b.6

Complement: The Terminal Pathway C5b.6 binds to C7 Next C5b.6.7

Complement: The Terminal Pathway C8 C5b.6.7 binds to C8 C5b.6.7

Complement: The Terminal Pathway C5b.6.7 binds to C8 Next C5b.6.7.8

Complement: The Terminal Pathway C5b C9 C5b binds molecules of C9 to form the Membrane Attack Complex C9

Complement: The Terminal Pathway C5b n C5b binds molecules of C9 to form the Membrane Attack Complex Next

Complement: The Terminal Pathway  The following slides are a graphical illustration of the terminal pathway  The end-point is the formation of the membrane attack complex which punches a hole in the bacterial membrane.  This loss of membrane integrity results in the death of the bacteria The graphics run automatically Next

Complement: The Terminal Pathway pathogen cell membrane

Complement: The Terminal Pathway C5b

Complement: The Terminal Pathway C6

Complement: The Terminal Pathway C7

Complement: The Terminal Pathway

C8

Complement: The Terminal Pathway C9

Complement: The Terminal Pathway

The Membrane Attack Complex End of Presentation