Recent progress in the Total Synthesis of typical lignans Pusheng Wang

Ligin ( 木质素 ) and Lignan ( 木酯素 ) 2 木质素（ Ligin ）是由四种醇单体（对香豆醇、 松柏醇、 5- 羟基松柏醇、芥子醇）形成的一 种复杂酚类聚合物。 木脂素（ Lignan ）是一类由两分子苯丙素衍 生物（即 C6-C3 单体）聚合而成的天然化合 物，多数呈游离状态，少数与糖结合成苷而 存在于植物的木部和树脂中，故而得名。通 常所指其二聚体，少数可见三聚体、四聚体。

Total synthesis of typical ligans in recent years 3

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Examination of the Mitsunobu etherification 8

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Summary Main source of chirality: 21