Liquid Filter Products Applications Training Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Beverage Applications Prefiltration Facility Water Compressed Gas Steam Detergents / Cleaning Solvents DE Trap Polishing Prior To Bottling Final Filtration Facility Water Facility Gas Tank Venting Chill Haze Removal Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Keg Filling - Bottle Filling - Can Filling Beer Filtration Raw Beer Diatomaceous Earth Filter F1 Aging Tank F1 F1 Holding Tank F2 Sheet Filter OR F3 F3 F3 Keg Filling - Bottle Filling - Can Filling Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Beer Filtration Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Wine Filtration Aging Tank Crushed Grapes Fermentation Fining Stage Sheet Filter Holding Tank Bottling Tank F2 F3 To Wine Cooler Processing Filling Station Wine Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Wine Filtration Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Wine Cooler Filtration Bulk Wine Storage Tank F2 F3 Carbonator Blend Tank Filling Station Wine Cooler Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Wine Cooler Filtration Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Food and Beverage Industry Process Water F1 Product Formulation Heating or Cooling F2 F3 Process Water Process Equipment F4 F5 CIP (Clean In Place) Sanitize Rinse Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Food and Beverage Industry Process Water Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Bio-processing of Food Products Steam F1 Seed Fermenter Compressed Air F5 F2 F3 F4 Harvest Vessel F11 F10 F9 F7 F6 F8 Ammonia pH Adjust Final Product Purification (Production) Nutrients or Make-up water Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Bio-processing of Food Products Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Soft Drink Filtration Corn Syrup F1 Storage Tank Flavor F3 Container Wash Filling Station Storage Tank Flavor Water Blending Tank Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Soft Drink Filtration Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Semiconductor Applications Bulk Chemical Distribution Systems (BCDS) VLSI-GRADE BULK-CHEMICAL MANUFACTURERS F2 F1 TO CHEMICAL DELIVERY SYSTEMS Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Semiconductor Applications Bulk Chemical Delivery 55 Gallon Drums IN-HOUSE “CHEM-MIX” AREAS F3 F4 Filtered Bulk Chemicals BOTTLES PACKAGERS, BOTTLERS, SPECIALTY MIXERS 55 Gallon Drums F4 Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Bulk Chemical Delivery Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Semiconductor Applications Deionized Water (DIW and UPW) Change-out cycle - 2 years Most competition Most price competitive Key Factors for Cold UPW Resistivity rebound – rinse-up TOC rebound gal. to reach 99% of feed values Extractables Retention Flow rate vs ΔP Graver Technologies 200 Lake Drive, Glasgow, DE 19702

DI Water Filtration F1 F2 F3 F2 F4 F5 F5 Storage Tank RO Incoming Reverse Osmosis System Resin Bed Ion Exchangers F2 Storage Tank UV Lights F3 F2 Polishing Bottles F4 F5 F5 Point-Of-Use Filters Graver Technologies 200 Lake Drive, Glasgow, DE 19702

DI Water Filtration Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Semiconductor Applications CMP (Chemical Mechanical Planarization) Slurry of abrasives for removing thin layers (angstrom) via both grinding and etching for presenting an extremely smooth & normal surface for photolithography Remove particulate while leaving abrasive components Customer objective: reduce scratches and increase yield$ Recommendations day & mixing tanks…. PMC >20 um global loop (recirc)…. PMC 10-20 um coarse rating results in removal of agglomerates without removal of abrasives Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Semiconductor Applications CMP Slurries CMP oxide slurries for silica removal pH 10-12 abrasive size 0.02 - 0.08 um agglomerates form from exposure to air CMP metal slurries for metal removal pH 2-4 Tends to settle; requires fast recirc. to keep suspended agglomerates Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Semiconductor Applications Chemicals Most common Photoresist strip Phosphoric acid RCA Etch (SC 1 and SC 2… contains 1/3 peroxide) Sulfuric acid (for making piranha in fab) Nitric acid Photoresists Developers Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Semiconductor Applications Tools Most common HF and BOE NOE (contains ethylene glycol…correct for viscosity when sizing) Acetone Piranha Baths 98% sulfuric acid; 2% hydrogen peroxide 3 - 6% more aggressive than “neat” sulfuric For removing metal Recirculating Etch Baths Using various % HF acid (attacks silica incl. glass) and BOE...buffered oxide etch (93% ammonium fluoride & 7% HF acid) Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Wet Tool Benches F5 F6 F7 F6 F5 F8 Wafer Cleaning “Piranha” “RCA Clean” F5 Primers e.g., HMDS F6 F7 Etchants Bottled Chemicals Developers, Rinses, Solvents F6 F5 Strippers Acid Processing Equipment F8 Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Tool Filtration Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Pharmaceutical Applications Prefiltration Facility Water Compressed Gas Steam Solvents & Intermediates LVPs (those to be terminally sterilized) Vaccines Fermentation Broth Serum / Culture Media Diagnostic Reagents Cosmetics / Creams / Lotions Orals / Ophthalmics Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Pharmaceutical Applications Biologicals (aseptic processing) Fermentation Products Fermentation Feed Air Final Filtration Facility Water Facility Air & Gas SVPs/LVPs Serum / Culture Media Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Process Water F5 System Schematic F1 Ion Exchange F2 Pretreatment Distilled Water Tank F5 Steam Generator F6 F3 F4 POINT OF USE DI Water Tank Pump F4 F4 F4 F4 F4 POINT OF USE F3 F4 Pump POINT OF USE The process water system produces sterile water that is used throughout the facility in the manufacture and testing of product, and in support of the plant. Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Process Water Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Fermentation Fermentation : Specific organisms are grown in culture vessels producing a byproduct which can be isolated from the fermentation broth (e.g., Citric acid, fructose, alcohol, or certain drugs) F1 Fermentation Tank Steam Coolant F2 F3 F3 F2 Fermentation Broth Additives F4 F5 INLET GAS SUPPLY Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Fermentation Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Antibiotic Processing Antibiotics Compounds intended to kill off specific bacterial infections. Made naturally as by-products of fermentation by certain bacteria, molds, and fungal species (e.g., Penicillin is a by-product of the mold genus penicillium). Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Antibiotic Processing F1 Seed Tank Bulk Clarification & Concentration Fermentation Vessel Steam F2 Coolant Solvent Precip’n HPLC Purification F3 Activated Carbon F5 F4 Ion Exchange Purification F6 F7 F8 Crystallization Depyrogenation Reconstitution Final Dosage Form Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Antibiotic Processing Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Therapeutic Production Therapeutics (other than antibiotics) Manufactured through a fermentative process, whether occurring naturally (e.g., Taxol), or as by-products from culture in genetically engineered organisms (e.g., Insulin). Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Therapeutic Production F1 F2 F3 Steam Inlet Gas Supply Fermentation Vessel Coolant Fermentation Broth/ Culture Media F4 F5 F5 F4 Growth Additives / Water, Serum Bulk Clarification F6 Isolation / Purification F7 Virus Removal Final Product Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Therapeutic Production Graver Technologies 200 Lake Drive, Glasgow, DE 19702

LVP/SVPs Large Volume Parenterals Small Volume Parenterals Generally fluid in nature Must be administered intravenously (e.g., TPA/TPN solutions, IV Bags). The filter is removes bacteria and any particulate that could block tiny blood vessels. Small Volume Parenterals Vials of liquid (usually fewer than 100 ml) or powder. The key to filtration is removal of bacteria and particulate impurities that could clog a blood vessel, or block the nozzle of a filling machine. Graver Technologies 200 Lake Drive, Glasgow, DE 19702

LVPs Parenteral Formulation QC Testing and Release Storage Tank Depyrogenation Autoclave QC Testing and Release Graver Technologies 200 Lake Drive, Glasgow, DE 19702

LVPs Graver Technologies 200 Lake Drive, Glasgow, DE 19702

SVPs Parenteral Ingredients Powders Vial/Stopper Washer Air Supply F2 Washer Air Supply F1 vials / stoppers Mix Tank F3 F4 Filling Machine Liquids Lyophilizer Powders F5 Graver Technologies 200 Lake Drive, Glasgow, DE 19702

SVPs Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Ophthalmic Solutions Ophthalmic Solutions Ointments, drops and medications placed intraocular. Filtration makes these sterile and safe to use by removing bacteria and particulate impurities that might scratch the cornea, or cause other discomfort in the eye. Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Ophthalmic Solutions System Schematic Petrolatum Drug Additives F2 F1 Heated Holding Tank F3 F4 Sterile Blending Tank Pump F5 Drug Additives Testing and Final Packaging Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Ophthalmic Solutions Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Glossary of Terms Antibiotic – class of compounds derived synthetically or naturally that have bacteriacidal characteristics BOE – buffered oxide etch – etch chemical composed of ammonium fluoride and hydrofluoric acid CMP slurry – chemical mechanical polishing - Slurry of abrasives used to remove thin layers (angstrom) from a wafer via both grinding and etching. Fermentation - process of converting sugars to harvestable intermediate of end products such as alcohol, antibiotics, HF – hydrofluoric acid Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Glossary of Terms LVP – Large volume parenteral – liquid intravenous solutions administered in doses of larger than 100ml NOE - etch chemical composed of ammonium fluoride and ethylene glycol Petrolatum – petroleum based “gel” Piranha - etch chemical composed of hydrogen peroxide and sulfuric acid. Graver Technologies 200 Lake Drive, Glasgow, DE 19702

Glossary of Terms Pyrogen –portion of the cell wall of a gram negative bacterial resulting in a pyrogenic (fever) reaction in mammalian systems RCA Etch – etch chemical composed of either hydrogen peroxide and ammonium hydroxide (SC1) or hydrogen peroxide and hydrochloric acid (SC2) SVP – small volume parenteral – liquids administered intravenously in volumes of less than 100ml VLSI Grade- purity grade of semiconductor chemicals – derived from Very Large Scale Integration Graver Technologies 200 Lake Drive, Glasgow, DE 19702