الاسم : سعد بن محمد نور بن محمد ولي الرقم الجامعي : التخصص : معيد بكلية الصيدلة قسم الأدوية Pharmacology احصاءات وجداول عن طريق برامج خاصة لأغراض التدريس والبحث العلمي

 Preparation of Solid Dispersions (SDs)of Ibuprofen with Different Drug-Carriers: Table(I): Formulation Design of Physical Mixtures of Ibuprofen with Different Drug Carriers F15F14F13 F12 F11 F10 F9 F8 F7 F6 F5 F4 F3 F2 F1 Composition Ibuprofen 531βCD 531 PEG PEG PVP K PVP K90

Table(II): Formulation Design of Ibuprofen SDs Prepared by Solvent Evaporation Method F30F29F28 F27 F26 F25 F24 F23 F22 F2 1 F20 F19 F18 F17 F16 Composition Ibuprofen 531βCD 531 PEG PEG PVP K PVP K90

 Determination of Maximum wave Length of Ibuprofen Absorbance: Fig(1): UV Spectrum of Ibuprofen in Absolute Alcohol

Table(III): UV Absorbanc of Ibuprofen at λ max 221 nm in Ethanol Concentration of Ibuprofen (ug/ml) Absorbance

 Determination of Drug Content in Different Formulae of Ibuprofen: Table(IV): Ibuprofen Content in Different Formulae Prepared with Different Drug Carrier FormulaConcentration(ug/ml)Drug content% F F F F F F F F F F F F F F F

Fig(3a): IR Spectrum of Ibuprofen

Fig(3b): IR Spectrum of Ibuprofen with βCD(1:5)

Fig(3c): IR Spectrum of Ibuprofen with PEG4000(1:5)

Fig(3d): IR Spectrum of Ibuprofen with PEG6000(1:5)

Fig(3e): IR Spectrum of Ibuprofen with PVP K30(1:5)

Fig(3f): IR Spectrum of Ibuprofen with PVP K90(1:5)

Fig(4):XRPD Diffraction of Ibuprofen with Different Drug Carriers(A: PVP K90(1:5), B: PVP K30(1:5), C: PVP K30(1:2), D: PEG 6000(1:5), E: PEG 4000(1:5), F: Ibuprofen, G: βCD(1:5)

Fig(5): DSC of Ibuprofen and its Physical Mixtures with Different Carriers(A: Ibuprofen ; B: PVP K30(1:5) ; C: βCD(1:5) ; D: PEG6000(1:5) ; E: PVP K90(1:5) : F: PEG 4000(1:5) ; G: PVP K90(1:2)

Time( min) %Ibuprofen Released PEG 6000 Witepsol H15 Cocoa butter Novata DE75 Witepsol W Table(X): Release of Ibuprofen from Different Suppository Bases: