Mentored Career Development (K) Award Outcomes National Advisory Council on Drug Abuse February 6, 2008 Lucinda L. Miner, Ph.D. Deputy Director, Office of Science Policy and Communications National Institute on Drug Abuse

NIDA Dashboard Medicinal Chemists -- How to facilitate recruitment and training Medicinal Chemists -- How to facilitate recruitment and training Collaborations with Other ICs -- How more might be encouraged Collaborations with Other ICs -- How more might be encouraged ? ? New PIs -- How they fare in obtaining first R01 -- How they fare in obtaining first renewal New PIs -- How they fare in obtaining first R01 -- How they fare in obtaining first renewal Clinical vs Preclinical Investigators -- How they compare in terms of success Clinical vs Preclinical Investigators -- How they compare in terms of success

NIDA Dashboard Medicinal Chemists -- How to facilitate recruitment and training Medicinal Chemists -- How to facilitate recruitment and training Collaborations with Other ICs -- How more might be encouraged Collaborations with Other ICs -- How more might be encouraged ? ? New PIs -- How they fare in obtaining first R01 -- How they fare in obtaining first renewal New PIs -- How they fare in obtaining first R01 -- How they fare in obtaining first renewal Clinical vs Preclinical Investigators -- How they compare in terms of success Clinical vs Preclinical Investigators -- How they compare in terms of success

NIDA’S Mentored Career Awards K01 - Mentored Research Scientist Development Award K08 - Mentored Clinical Scientist Development Award Program K12 - Mentored Clinical Scientist Development Program Award K23 - Mentored Patient-Oriented Research Career Development Award K25 - Mentored Quantitative Research Career Development Award K99/R00 – Pathway to Independence Award

Mentored K Development Awards FY Number Supported

Mentored Career Development (K) Award Outcomes – (K01, K08, K23) Awardees Supported in FY 1999 and 2000

Mentored K Awardees by Degree 1999 N = N = 78 n = (25) (14) (39) n = (16) (9) (29)

Current Research Involvement 1999 Total MDs = 16 Total MD-PhDs = 9 Total PhDs = Total MDs = 25 Total MD-PhDs = 14 Total PhDs = 39 ( ) (last yr of K support-2005) ( ) ( ) (last yr of K support-2006) ( ) MD MD-PhD PhD

Subsequent Funding Activity to 2005/ Total MDs = 16 Total MD-PhDs = 9 Total PhDs = Total MDs = 25 Total MD-PhDs = 14 Total PhDs = 39 MD MD-PhD PhD

Subsequent Funding Activity Clinical Research vs Preclinical 2000 Total K01 or K08 Awardees = 69 Total K23 Awardees = 9 K01 or K08 K23

Subsequent Funding IC 1999 Total Funded MDs = 6 Total Funded MD-PhDs = 5 Total Funded PhDs = Total Funded MDs = 11 Total Funded MD-PhDs = 7 Total Funded PhDs = 20 MD MD-PhD PhD

Career Trajectories

Mentored K Development Awards FY Number Supported

American Academy of Child and Adolescent Psychiatry Physician Scientist Program (K12) in Substance Abuse Increase the number of child psychiatrists carrying out drug abuse research Increase the visibility and presence of drug abuse research in child psychiatry Program established in Jan 1998 First cohort, Second cohort,

AACAP-NIDA K12 Program 1 st Cohort Outcomes Seven scholars participated in the first cohort

AACAP-NIDA K12 Program: First Cohort Scholar Outcomes as of January 2008 Grant Funding Scholar 1 Scholar 2 Scholar 3 Scholar 4 Scholar 5* Scholar 6 Scholar 7 Total NIH Grants Awarded as PI (R level) Non-Federal Grant Awards as PI NIH Grants Submitted/Un der Review as PI NIH Grant Support as Co I Total Number of Grants 1 PI 1 Co I 3 PI 7 Co I 1 PI 7 Co I 9 PI 7 Co I 5 PI 5 Co I 1 PI 0 Co I 0 PI 0 Co I 20 PI 27 Co I Data obtained through a self report evaluation requested annually through the AACAP-NIDA K12 Program. NIH grant data obtained through the CRISP database - January 2008.

AACAP-NIDA K12 Program: Scholar Outcomes as of January 2008 Publications Scholar 1 Scholar 2 Scholar 3 Scholar 4 Scholar 5* Scholar 6 Scholar 7 Total 1 st Authored Publications (Refereed) st Authored Publications (Non-refereed) Other Publications Total First Authored Publications Total Publications *All data obtained through a self report evaluation requested annually through the AACAP-NIDA K12.

AACAP-NIDA K12 Program 1 st Cohort Outcomes Five of seven received NIH independent research support within 2 yrs of completing the program Four out the five are PI’s on NIDA funded research grants

AACAP- NIDA K12 Second Cohort

AACAP-NIDA K12 Program Second Cohort Preliminary Outcomes: Publications as of January 2008 PublicationsScholar 1 Scholar 2 Scholar 3 Scholar 4 Scholar 5 Total 1 st Authored Publications (Refereed) st Authored Publications (Non- refereed) Other Publications Total First Authored Publications to Date Total Publications to Date st Authored Publications Pending/Under Review

AACAP-NIDA K12 Program Second Cohort Preliminary Outcomes: Grant Funding as of January 2008 Grant Funding Scholar 1Scholar 2 Scholar 3 Scholar 4 Scholar 5 Total NIH Grants Awarded as PI (R level) Non-Federal Grant Awards as PI NIH Grants Submitted/Und er Review as PI

Impact on Child Psychiatry

AACAP-NIDA K12 Program: Change in Number of Substance Abuse Related Research Presentations at the AACAP Annual Meeting *Other Oral Presentations includes Institutes, Workshops and Clinical Perspectives sessions. First cohort Research Presentations

AACAP-NIDA K12 Program: K12 Scholars’ Participation in the AACAP Annual Meeting

NIDA Dashboard ? ? Medicinal Chemists -- How to facilitate recruitments and training Collaborations with Other ICs --How more might be encouraged Clinical vs Preclinical Investigators --How they compare in terms of success New PIs --How they fare in obtaining first R01 --How they fare in obtaining first renewal

Mentored Ks Received vs. Funded (FY ) Number of K Applicants

Mentored Ks by Degree K01, K08, K23 Number Supported

Mentored K Success Rates by Degree ( K01, K08, K23) Number Supported

Success Rates of R01-Equivalent Applications (FY 2007) NEW NIH NIDA COMPETING CONTINUATION Original A1 A2 Original A1 A2

Original Applications 1 st Amendments (A1) Success Rate (%) Overall New Investigator Non-New Investigator 2 nd Amendments (A2) Success Rate (%)