Luke the Limping Labrador Linden Craig, DVM, PhD, DACVP Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Signalment 10 year old Intact male Black Labrador retriever Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Clinical History One year duration Swelling and lameness Left stifle Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Luke at UT Painful swollen stifle FNA – viscous fluid Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

UT Radiographs Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Biopsy Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Diagnosis? Synovial myxoma Benign, slow growing Nodular morphology Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Synovial Myxoma 1. Adult Doberman – stifle synovectomy  curative yr old Doberman – stifle amputation  curative 3. 9 yr old English spaniel – C2 & C3 incidental finding at necropsy Tumors in Domestic Animals 4 th ed, DJ Meuten Ed, 2002, p. 213 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Synovial Myxoma 1.Labrador retriever – tarsus 2.Miniature poodle – stifle 3.Doberman cross – carpus 4.Doberman cross – stifle 5.Doberman – carpus 6.Doberman – stifle doxorubicin  died The diagnosis and prognosis of synovial tumors in dogs: 35 cases Vet Path 39:66-73, 2002 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Luke’s Leg Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Synovial Myxoma Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Invasion into bone Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Synovium Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Synoviocytes Secrete synovial fluid Dendritic cells + Type C synoviocyte Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Synoviocytes H&E CD18 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Synoviocytes  tumors (Craig Hypothesis) Type A – Dendritic cell –Histiocytic sarcoma Type B – Secretes synovial fluid –Synovial myxoma Type C – Transitional or stem cell –Synovial cell sarcoma Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Synovial Tumors - Survival The diagnosis and prognosis of synovial tumors in dogs: 35 cases Vet Path 39:66-73, 2002 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Synovial Myxoma Summary Slow growing Nodular Benign Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only