JOSHUA NORD LORA RAPP NATHANIEL WANISH CONCORDIA UNIVERSITY OF WISCONSIN MAJOR HISTOCOMPATIBILITY COMPLEX - CLASS I HLA-A2 AND PRESENTATION OF HERPES VIRAL.

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JOSHUA NORD LORA RAPP NATHANIEL WANISH CONCORDIA UNIVERSITY OF WISCONSIN MAJOR HISTOCOMPATIBILITY COMPLEX - CLASS I HLA-A2 AND PRESENTATION OF HERPES VIRAL PEPTIDES

Big Picture Human immune system - Cytotoxic T lymphocytes (CTL) - Viral peptide presentation Major Histocompatibility Complex Class I (MHC) -structure Human Herpesvirus-7

Class I MHC Formation Synthesis Cnx = Calnexin HC = MHC α-chain Crt = Calreticulin Tpn = Tapasin

U21 Down regulation of MHC Class I

The Future X-ray crystallization of MHC & U21 Diversion of MHC to lysosomal compartments Alternate NK cell evasion

MHC in the Classroom Model - interactions - anchor residues - peptide presentation