Jeopardy Phases of Wound Healing Heritable Diseases Specific Tissues Factors affecting wound healing Treatment Q $100 Q $200 Q $300 Q $400 Q $500 Q $100 Q $200 Q $300 Q $400 Q $500 Final Jeopardy

$100 Question from H1 Name the three phases of wound healing.

$100 Answer from H1 a.Hemostasis and inflammation b.Proliferation c.Maturation and remodeling

$200 Question from H1 In the hemostasis phase, these are the first infiltrating cells to enter the wound site, peaking at 24 to 48 hours.

$200 Answer from H1 PMNs

$300 Question from H1 In the proliferation phase, these cells proliferate extensively and participate in the formation of new capillaries?

$300 Answer from H1 Endothelial cells

$400 Question from H1 They couple with proteins to form proteoglycans, and compromise a large portion of the “ground substance” that makes up granulation tissue.

$400 Answer from H1 Glycosaminoglycans

$500 Question from H1 Breaks down collagen in the maturation and remodeling phase.

$500 Answer from H1 Matrix metalloproteinases (MMPs)

$100 Question from H2 Genetic defect is in an extracellular protein, fibrillin, and presents with tall stature, arachnodactyly, lax ligaments, pectus excavatum, and aneurysms.

$100 Answer from H2 Marfan’s Syndrome

$200 Question from H2 Defect in collagen formation. Thin, friable Skin with prominent veins. Associated with GI problems

$200 Answer from H2 Ehler-Danlos Syndrome

$300 Question from H2 Mutation in Type I collagen, four major subtypes, dermal thining and increased bruisability.

$300 Answer from H2 Osteogenesis Imperfecta

$400 Question from H2 Classified into 3 major subtypes. impairment in tissue adhesion within the epidermis, basement membrane, or dermis, resulting in tissue separation.

$400 Answer from H2 Epidermolysis Bullosa

$500 Question from H2 An autosomal recessive disease of children that causes an inability to absorb sufficient zinc from breast milk or food. Impaired granulation tissue formation.

$500 Answer from H2 Acrodermatitis Enteropathica

$100 Question from H3 The early integrity of a bowel anastamosis is dependent on formation of a fibrin seal on the serosal side, which achieves watertightness, and on the suture-holding capacity of the intestinal wall, particulary which layer?

$100 Answer from H3 Submucosal layer

$200 Question from H3 With a nerve injury, these cells ensheathe and help in remyelinating the regenerating axons.

$200 Answer from H3 Schwann cells

$300 Question from H3 What is the main characteristic that distinguishes the healing of fetal wounds from that of adult wounds?

$300 Answer from H3 Scar formation

$400 Question from H3 Cartilage consists of these cells, surrounded by an extracellular matrix made up of several proteoglycans, collagen fibers, and water.

$400 Answer from H3 Chondrocytes

$500 Question from H3 The fetal wound is characterized by excessive and extended production of what glycosaminoglycan?

$500 Answer from H3 Hyaluronic Acid

$100 Question from H4 This medication inhibits the inflammatory phase of wound healing and the release of lysosomal enzymes.

$100 Answer from H4 Steroids

$200 Question from H4 The best known of the metabolic disorders contributing to increased rates of wound infection and failure.

$200 Answer from H4 Diabetes Mellitus

$300 Question from H4 What perioperative measure can be taken to decrease wound infection rate by 66%?

$300 Answer from H4 Prophylactic antibiotics

$400 Question from H4 This deficiency impairs wound healing, while supplement benefits wound healing in nondeficient humans and animals.

$400 Answer from H4 Vitamin A

$500 Question from H4 With this deficiency, there is decreased fibroblast proliferation, decreased collagen synthesis, impaired overall wound strength, and delayed epithelialization.

$500 Answer from H4 Zinc

$100 Question from H5 This dressing uses negative pressure to increase the rate of wound healing by increasing blood flow to subcutaneous tissues.

$100 Answer from H5 V.A.C. Dressing

$200 Question from H5 List a complication of sulfamylon treatment.

$200 Answer from H5 Metabolic acidosis

$300 Question from H5 This is a serious complication of Silvadene application.

$300 Answer from H5 Leukopenia and Neutropenia

$400 Question from H5 This treatment has a serious complication of hyponatremia and methemoglobinemia.

$400 Answer from H5 Siver nitrate

$500 Question from H5 These two concepts are critical in selecting appropriate dressing.

$500 Answer from H5 Occlusion and absorption

Final Jeopardy Who were the first people to differentiate between infected and diseased wounds compared to noninfected wounds?

Final Jeopardy Answer The Egyptians