Young man with progressive neurological decline. History of present illness 21 yo male with a progressive neurological decline over 2 months – Difficulties.

Slides:



Advertisements
Similar presentations
Advanced Neuro Assessment
Advertisements

SIDS S – Sudden I – Infant D – Death S – Syndrome.
MOTOR NEURON DISEASE The motor neuron diseases (or motor neuron diseases) (MND) are a group of neurological disorders that selectively affect motor neurons.
Unusual Case of Myasthenia Gravis and High White Blood Cell Count
Spinal Cord Dysfunction
SNS Intern Course Case Scenarios Case # 7 63 yr old left handed female presents with progressive headache, left homonymous hemianopia and left hemiparesis.
Atypical Polymyalgia Rheumatica
Neurology 2 Part 3. Assessing Motor System Muscle Strength Tone – Tension pressure when the muscle is at rest Spasticity – Increase muscle tone Rigidity.
GAIT DISTURBANCES Anshul Jain.
Practical Management of MS in the Primary Care Office Setting Case Study 2.
Acute Neurology Clinical Vignettes Session 6. 1.You are called to the E.R. to evaluate a 23 y/o Chinese male for left ophthalmoplegia. He is a juvenile.
37 yo F Engineer PC: Double vision, fatigue, difficulty swallowing. HPC: - 3/52 of worsening diplopia, worse in afternoons - 3/7 of intermittent weakness.
Jordan Smedresman SUNY Downstate College of Medicine Class of 2013.
THE NEUROLOGICAL EXAMINATION
4 patients falling over. Mrs April Aged 62 Complains of tripping up when she walks on uneven surfaces Falls over and comes to hospital PMH COPD Vegan.
The Neuro Exam Yes, you really do have to wake them up and do this Last Updated by Lindsay Pagano Summer 2013.
Brain Health.
Ed Hutchison and Paul Swift
Midbrain syndromes Idara Eshiet C..
Tinnitus in 44 y/o female Richard Lukose. Presents to family doctor A 44 y/o female Tinnitus in right ear for 1 month, worsening PMHx: obesity Medications:
The Motor System and the Cerebellar Function
Clinical Hx (Case 1) 22 year old male. Ejected from a vehicle during a high speed single vehicle rollover. Immediate complaints of chest and back pain.
NYU Medicine Grand Rounds Clinical Vignette Joshua Strauss, MD PGY2 February 2, 2011 U NITED S TATES D EPARTMENT OF V ETERANS A FFAIRS.
Clinical Correlations The NYU Internal Medicine Blog A Daily Dose of Medicine
Spinal cord compression in mucopolysaccharidosis Agnes Chen, MD K30 Case Study 23 March 2010.
Vignettes Session 6 new R. Wiley, MD, PhD
Huntington Disease Genetic Disorder Project Alaukika Desai AP Biology Period 3.
Lumber Spine Assessment Ahmed alhowimel,MSc.PT. Screening…  Red Flags. Means serious underlying condition that require more medical investigation like.
Advanced Neuro Assessment
Diagnostic Challenge Pathology for Neurosurgery & Neurology Residents Department of Pathology University of Oklahoma Health Sciences Center, Oklahoma City,
DEPRESSION Dr.Jwaher A.Al-nouh Dr.Eman Abahussain
Neuroradiology Unknowns
Vignettes #8 Ronald G. Wiley, MD, PhD Christopher Lee, MD, MS
Innovations in Parkinson’s Diagnosis & Treatment: A Personal Story Dr. Kenneth E. Keirstead Excellence in Aging Care Symposium September 25-27, 2013.
10 Second Case Studies Round 2: Degenerative Neurological Conditions.
Practical Management of MS in the Primary Care Office Setting Case Study 1.
Cases Neuroscience. Case 4 A 45 year old woman with a history of hypertension experienced a brief "blackout". She had complained of severe headaches,
Human Physiology Multiple Scolerosis. Multiple sclerosis is an autoimmune disease that affects the brain and spinal cord (central nervous system) autoimmune.
Clinical reasoning By Dr. Walid I. Wadi Jan,5 th 2010.
D.H. Clinical Pathology Conference August 24, 2015 Stella Lai MD Ronald Hamilton MD.
Preview Bellringer Key Ideas Physical Changes Mental and Emotional Changes Social Changes Chapter 16 Section 1 Changes During Adolescence.
4 year old boy comes in with painful, swollen R ankle after having fallen off of a swing 6 hours previously, landing on his knee. No history of bruising;
Vignette Session Session 5 - new R. Wiley with L. Bederman.
ALTERATIONS OF THE CENTRAL NERVOUS SYSTEM Assessment of a CVA F.A.S.T Face Arms Speech Time* * =9015&news_iv_ctrl=1222.
NYU Medical Grand Rounds Clinical Vignette Megha Shah PGY-2 November 10, 2010 U NITED S TATES D EPARTMENT OF V ETERANS A FFAIRS.
2 John is a 57 year old man who developed gait difficulty which has worsened over the past months. He noticed that he needed to stand for apart to maintain.
Cases Neuroscience. 1. Which of the following structures is located at the irregularity indicated by the black arrow in the fissure shown in the image.
Neurological Exam: Still Important After All These Years Eric Kraus, MD Neurology.
DR.JAWAHER A. AL-NOUH K.S.U.F.PSYCH. Depression. Introduction: Mood is a pervasive and sustained feeling tone that is experienced internally and that.
November 26, HPI 14 month old male seen by PCP intially for fever and nasal congestion with purulent nasal discharge and cough. At initial visit.
POTASSIUM BALANCE Alan C. Pao, M.D. Division of Nephrology Cell:
Andrew Levin, PGY3 Ronald Hamilton, MD. 64 y/o woman with a hx of HTN, DM1 and ESRD transferred urgently to PUH ED from local vascular outpatient surgery.
PARKINSON’S DISEASE.
What Is a Stroke? Stroke is the blocking or bursting of a blood vessel that supplies blood to the brain. During a stroke a portion of the.
Developmental Disabilities Medical and Psychosocial Aspects.
A CASE REPORT BY: MAUREEN SABRI, SPT Does CNS-depressive medication impact the physical therapy prognosis of a 65 year-old patient with chronic stroke.
Title Description Authors Albuquerque, NM Background Results Conclusion/Limitations References History of Present Illness: A 28-year-old Spanish-speaking-only.
Stumper: Too Young for Chest Pain. Stumper A 23 yo man presents to the ED with 4 hours of chest pain –Healthy Denies cigarette smoking, FHx, DM, Hypertension.
Case presentation in normal pressure hydrocephalus 中國醫藥大學附設醫院神經部 楊玉婉.
THE NEUROLOGICAL EXAMINATION
NIH Stroke Scale NIH Stroke Scale/Score (NIHSS)
The Neurological System
Upper limb PNS examination
Neurological Assessment
Case 3 Headache & Slurred Speech Case Presentation
Amyotrophic Lateral Sclerosis
Assessing your patient
The Basic Neurological Exam (Part I)
PCA TRAINING PROGRAM.
Presentation transcript:

Young man with progressive neurological decline

History of present illness 21 yo male with a progressive neurological decline over 2 months – Difficulties with gait- unsteady, wide based, “stuck” – Dysarthria- severe, caretaker barely unable to understand over 2 month period – Sialorrhea – Tremors – affecting ability to eat, dress, ect – Incontinence – Syncope/LOC episodes – Decreased facial expression – Decreased PO intake, associated with nausea/vomiting, wt loss – Dependent on caretakers for ADL’s At baseline: very active and social, very well liked by foster family and housemates 3-4 months ago was playing basketball and running on the beach

Social history Currently living in adult foster home for past 2 years, after he could no longer complete an attempted degree at community college (became “sick”) Graduated high school, but had IEP. Grade school he did quite well academically (normal IQ on testing at age 15) – Was seen by MH as teen and dx with Autism and ADHD Significant gaps in social hx as patient “tragically removed from home” at age of 13, living in foster care since that time No tobacco, alcohol or drug use history

Family history Largely unknown – Biological mother died in car accident when he was 14 years old – Biological father unknown and presumed not to be alive – Half-sisters: healthy

Neurological Exam MS: Alert, O x 3, very hypophonic and dysarthric, one word answers, able to name and repeat, follow commands, upbeat mood CN: PERL, EOMI, Face symmetric, VFF, tongue midline but with tremor, V1-3 intact, equal shoulder shrug, equal palatal elevation Motor: Increased tone in lower ext > upper ext, 5/5 strength in all 4 ext Reflexes: 3+ left biceps rest of LUE 2+, 2+ RUE, 3+ patella b/l, 4+ ankles b/l, toes upgoing b/l, clonus that sustained for 8-9 beats, crossed adductor on RLE Sensation: Sensation to light touch intact throughout Coordination: Finger to nose with end point tremor R>L. Finger tapping and hand opening irregular and reduced amplitude. Heel to shin very bradykinetic, with slowed tapping of feet. Gait: Small, shuffling steps with decreased arm swing, very bradykinetic. Needs 1 person assit or walker to maintain balance. En block turning.

Video

2 nd Video

Labs CBC, wnl except slightly depressed Plt ct (121) CMP- wnl UA- unremarkable Ammonia- 51 (11-53)

Imaging, MRI FLAIR

Imaging, MRI T2

Imaging, MRI DWI

Rest of work-up TSH/T4, RPR, B12, folate- WNL Uric acid 3.9 (WNL) Serum copper 34 (70-140) 24 hr-urine copper 182 (<50) Ceruloplasmin<6 (20-60) Rechecked LFT and INR- WNL Liver US: Heterogeneous and coarsened parenchyma without focal lesion. Hepatology and Ophthalmology consults Liver biopsy: mild to moderate fibrosis, stage 2 – Hepatic copper concentration: ug/g (15-55)

Diagnosis Wilson’s disease