Job bag number: UK/TB/0214/0025 Date of preparation: May 2014 L-γ-Glu DesB30 insulin Glutamic acid ‘spacer’ DesB30 T T Des(B30) LysB29(γ-Glu Nε-hexadecandioyl)

Slides:

Advertisements

Similar presentations

Atom Building block of life (MOLECULES/COMPOUNDS).

Advertisements

Nucleic Acids Nucleic Acid Basics Contain instructions to build proteins 2 types: – DNA – RNA Composed of smaller units called nucleotides – Monomer:

Diabetes Revision of protein structure and the importance of genetic engineering in the control of diabetes.

– Carbohydrates – Lipids (fats) – Proteins – Nucleic Acids Organic molecules are the molecules in living things There are four types of organic (carbon-based)

Bioequivalence of Locally Acting GI Drugs

Incretins: Expanding Role in Treatment Strategies Pediatric Type 1 Diabetics (n=8) Insulin dose reduced 20% with exenatide dosing – mixed meal.

Insulin Produced by beta-cells in pancreas Hormone involved in regulation of blood glucose levels tells liver, muscle and fat cells to take up glucose.

©2013 America’s Job Link Alliance 12.5 Release Review America’s Job Link Alliance Annual Meeting Mobile, AL December 2013.

Pharmaceutical Biotechnology PHT 426 “Insulin (1)” Dr. Mohammad Alsenaidy Department of Pharmaceutics College of Pharmacy King Saud University Office:

Tutorial 1 January 18, 2013.

Pancreatic Hormones and Insulin Receptor Agonists Hongmei Li Mar. 21th, 2006.

Title your page: Polymerization Notes Set up your page for Cornell Notes:

Type I Diabetes. Diabetes Drinking heaps, urinating heaps Massive weight loss –“Flesh melting into Urine” –Diabetes = ‘Siphon’ Death inevitable within.

New Insulin Formulations

Introduction to Proteins

Amino acids are coded by mRNA base sequences.

BIOACCUMULATION Lauren Campbell. What Is Bioaccumulation? Bioaccumulation is the build up of a biological substance in organisms. This can happen at any.

Insulin degludec (Tresiba®)

 1-What is the best drug to be used?  2-How it is going to be given?

Organic MACROMOLECULES Large & complex CHONPS atoms polypeptide polysaccharide CELLULOSE.

Chapter 9 Type 1: What does the word “organic” mean to you? What immediately comes to mind?

Antidiabetic drugs. Genetically Engineering Insulin DNA strands can be separated and used as templates for new DNA synthesis An 18 base synthetic.

Introduction Subcutaneous insulin absorption is not reproducible and insulin entry directly into the circulation is not linked to glucose sensing Basal.

 Insulin Degludec  Ultra long action  Due to formation of soluble multihexamers at the injection site from which monomers gradually separate and are.

Glargine (Lantus®) 15/6/2007. Dr. HK Pang.

Jill Little Diabetes Specialist Nurse

Kamlesh Khunti, Xavier Cos, Guy Rutten Primary Care Diabetes

Insulin Degludec Drugbank ID :DB09564

Origin & Composition of Cells

Proteins – V2.

FISIOPATOLOGÍA TECNOLOGÍA MÉDICA Y FONOAUDIOLOGÍA

Protein Synthesis.

How To Add A Xerox Printer To Google Chrome

Frio River Cabins - Frio Vacation Homes - Frio Country Resort

Intermyocellular fat depot

'. \s\s I. '.. '... · \ \ \,, I.

Jill Little Diabetes Specialist Nurse

Types of insulin Domina Petric, MD.

Figure 4 Amino acid structure of short-acting and long-acting insulins

Macromolecules Ms. Lindberg.

در تجزیه و تحلیل شغل باید به 3 سوال اساسی پاسخ دهیم Job analysis تعریف کارشکافی، مطالعه و ثبت جنبه های مشخص و اساسی هر یک از مشاغل عبارتست از مراحلی.

Figure 3 Polysaccharides from plants and mushrooms

!'!!. = pt >pt > \ ___,..___,..

Topic 6 Human Physiology

Glucose homeostasis: roles of insulin, glucagon, amylin, and GLP-1.

Diffusion and Osmosis.

' '· \ ·' ,,,,

Figure 1 Influence of diet on gut microbiota and blood pressure

Figure 1 CD36 structure and post-translational modifications

Figure 3 Pharmacodynamic action profiles of long-acting insulins

Nat. Rev. Endocrinol. doi: /nrendo

Amino acids are coded by mRNA base sequences.

Evolution of Insulin: From Human to Analog

Food - any substance that your body can use as a raw material to sustain its growth, repair it and provide energy enzymes - special proteins that catalyze.

Day 2: Balancing Redox Reactions in Acidic or Basic solutions

Thing / Person:____________________ Dates:_________________

Firebase Vs. MongoDB: Choose the Best Database of 2019

Exogenous CRP administration causes fasting hyperglycemia and hyperinsulinemia without altering body composition. Exogenous CRP administration causes fasting.

Schematic describing metabolism of selected amino acids and the related production of metabolic stimulus-secretion coupling factors involved in insulin.

Model for the regulation of insulin secretion in the β-cell stimulated by glucose and amino acids. Model for the regulation of insulin secretion in the.

Neuronal glutamate that is released into the synaptic space is normally removed from the synaptic space by adjacent glial cells, in which the glutamate.

Plasma glucose, GIR, rates of EGP and glucose utilization, and plasma concentrations of free fatty acids (FFAs) and β-hydroxy-butyrate after a subcutaneous.

An insulin simplification regimen: from multiple injections to once-daily long-acting (basal) insulin plus noninsulin agents. *Basal insulins: glargine.

Complete Vehicle Systems.

Presentation transcript:

Job bag number: UK/TB/0214/0025 Date of preparation: May 2014 L-γ-Glu DesB30 insulin Glutamic acid ‘spacer’ DesB30 T T Des(B30) LysB29(γ-Glu Nε-hexadecandioyl) human insulin s s s s A1 B1 A21 ss TYGEECYCCNLQLSISQVINC PT Y YFFFGGGREECCVLLAVLHSLHQ N VK Hexadecandioyl Fatty diacid side chain Insulin degludec: rationally designed, beyond sequence modification

Job bag number: UK/TB/0214/0025 Date of preparation: May 2014 Insulin degludec injected Long multihexamer chains assemble [ Phenol; Zn 2+ ] Insulin degludec: immediately after injection Phenol from the vehicle diffuses quickly, and insulin degludec links up via single side-chain contacts Jonassen et al. Pharm Res 2012;29:2104–14

Job bag number: UK/TB/0214/0025 Date of preparation: May 2014 Insulin degludec: slow release following injection [ Zn 2+ ] Insulin degludec multihexamers Zinc diffuses slowly causing individual hexamers to disassemble, releasing monomers Subcutaneous depot Monomers are absorbed from the depot into the circulation Jonassen et al. Pharm Res 2012;29:2104–14