Molecule of the Week ATP Synthase. ...a nanoscale machine ● Two molecular motors / generators ● Enzyme ● Ion pump Function: Synthesize ATP / Create proton.

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Presentation transcript:

Molecule of the Week ATP Synthase

...a nanoscale machine ● Two molecular motors / generators ● Enzyme ● Ion pump Function: Synthesize ATP / Create proton gradient

ATP – Adenosine triphosphate ● Cellular energy „currency“ ● DNA replication / transcription ● Cell signalling

ADP + P i → ATP

ATP – Production ● Photosynthesis

ATP – Production ● Photosynthesis ● Aerobic respiration

ATP – Production ● Photosynthesis ● Aerobic respiration ● Anaerobic respiration

Structure determination of F1 ● “Structure at 2.8 Å resolution of F1-ATPase from bovine heart mitochondria”, Abrahams, Leslie, Lutter and Walker, Nature Vol. 370, 1994 ● Boyer and Walker shared half of the 1997 Nobel Prize in Chemistry

Molecular structure Cell membrane Inside cell organelle Diameter: 9 nm

FO part

Ion motor

F1 part

Binding change / „Flip-flop“ mechanism

F1 part Binding change / „Flip-flop“ mechanism

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