The 2nd generation of Fractional Tx. With CIS-F1

What is LASER ? L : Light A : Amplification S : by Stimulated www.sellaslaser.com L : Light A : Amplification S : by Stimulated E : Emission R : of Radiation

Diagram of a laser www.sellaslaser.com

Diagram of a laser www.sellaslaser.com

What makes laser different from other light Sources? www.sellaslaser.com ■ Monochromaticity ■ Coherence : the waves are in phase in time and space. ■ Collimation

Laser and Tissue Interaction: Laser targets chromophore www.sellaslaser.com For effective use of laser, practitioners must understand ‘Laser tissue interaction ’

Laser and Tissue Interaction: Laser targets chromophore www.sellaslaser.com Typical chromophores (chromophores’ absorbing laser in tissue): Water (Chromophore of CIS-F1) Hemoglobin and Oxy-hemoglobin Melanin (including Hair)

Laser and Tissue Interaction www.sellaslaser.com Laser interacts with tissue by absorption, scatter and/or transmission. Grothus Draper Law : Laser application of tissue is based on the absorption. Absorption Transmission Scatter Reflection : 4-7% on skin surface Refraction X V “Laser light must be perpendicular with skin surface to minimize refraction” Without incident angle “No Absorption No Effect”

Laser Tissue Absorption Spectrum www.sellaslaser.com 532 nm (KTP) 585 nm (Pulsed Dye) 2940 nm (Er:YAG) 10,600 nm (CO2) 200 1000 5000 0.1 1 10 100 20000 Hb HbO2 1550 nm (Er:Glass)

3 Skin Layers www.sellaslaser.com

Laser and Tissue Interaction www.sellaslaser.com Vaporization (>100 ºC) Necrosis & Coagulation (58-85 ºC) Protein Denaturation (> 60 ºC) Photobiomodulation (< 40 ºC) LASER Ablative Laser (CIS-F1) Benefit Injury

Laser and Tissue Interaction www.sellaslaser.com Fractional irradiation Fractional Tx. delivers multiful micro-beams, which hits the surface of skin in a fractionated manner and allows for fast healing by intact surrounding healthy Tissues. Benefit

Laser and Tissue Interaction www.sellaslaser.com Cytokine GF

Skin Tissue Interaction(CIS-F1) www.sellaslaser.com 10mJ, Moving mode (50mm tip) Depth: 230㎛ Width: 80 ㎛ ** Slides of porcine skin 250mJ, Stamp mode (50mm tip) Depth: 1800㎛ Width: 150 ㎛ 200mJ, Stamp mode (100mm tip) Depth: 1350㎛ Width: 200 ㎛

Selective Photothermolysis www.sellaslaser.com Laser Light Absorbed Target Non absorbed target *Temperature in the absorbed target will rise.

Termal Relaxation Time(TRT) www.sellaslaser.com Small Blood Vessels are Typically <450 us Melanosome is Typically <10ns to 100 ns

Comparison CIS-F1 Sellas-evo (10600㎛ fractional) (1550㎛ fractional) www.sellaslaser.com CIS-F1 (10600㎛ fractional) Sellas-evo (1550㎛ fractional) Ablative approach Excellent in skin resurfacing More effective on single Tx. Require less than 3 Tx. Combination enhancement Prone to surface of skin Tx. (face lift effect) Non-ablative approach Excellent in skin rejuvenation Minimal downtime Require less than 5 Tx. Combination enhancement Prone to dermis Tx. (face volume up effect)

Keratinized outer layer (enhance absorption of topicals) -Termal peeling. -How it works. www.sellaslaser.com Structural change in Keratinized outer layer (enhance absorption of topicals) Biomodulation < 40˚C (Activity of cytokine ) Stimulation of functional cells (Cytokine,GF…)

CIS-F1 ▪ Specification www.sellaslaser.com Laser source RF CO2 Laser Wavelength 10600nm Operation mode Stamping / Moving (Scanning) Pulse energy Stamp: 1-250mJ (Depth: 0.2~1.5mm) Moving: 1-50mJ Pattern size Handpiece diameter 30mm tip (microbeam dia. 150㎛) Interface Touch Screen Weight 30kg Dimension 40(W)x55(D)*90(H)cm

CIS-F1 Tip length (Focal length) 50mm 100mm Surgical tip Microbeam Size 80㎛ 120㎛ Power Higher than 100mm tip applied Lower than 50mm tip applied Application Deep penetration (Deep scar) Skin resurfacing Incision, Cutting, Nevus removal

CIS-F1

CIS-F1 User mode - easy to pick up the preset protocol

Tailoring the treatment zone www.sellaslaser.com ▪ Tailoring the treatment zone by drawing on canvas (X-Y scanner). ▪ Customized design is allowed for intensive treatment without excessive damage to surrounding tissues. Tailoring the spot pattern

Regular forms [ 16 standard regular forms] [ Max. 250mJ per micro dot] www.sellaslaser.com [ 16 standard regular forms] [ Max. 250mJ per micro dot]

www.sellaslaser.com Cooling and topical anesthesia before “ high energy” procedures 30% lidocaine gel is applied on face; occlude for 30-40 mins with BioMask

Terminology of Laser www.sellaslaser.com Dr. Gabriel Serrano, Spain Immediate redness after Sellas laser

Terminology of Laser www.sellaslaser.com Stamping mode Dr. Gabriel Serrano, Spain

Terminology of Laser www.sellaslaser.com Moving mode Dr. Gabriel Serrano, Spain

Post-Care Treatment www.sellaslaser.com Factors: Moisturizing / Anti-inflammatory / Revitalization / Sunscreen Sunscreen above SPF 50 Vitamin C Retinol at night EGF, bFGF, Amino acid, Mineral, Co-enzymes, Necleonic acid Copper peptide, Glyco-protein 1. Fast recovery against PIH after laser treatment (Whitening) 2. Improving skin tone and firmness (tightening). 3. Anti-aging restructuring of skin tissue 4. Post-trauma skin repair

Immediate care & First week after treatment Post-Care Treatment www.sellaslaser.com Post CIS-F1 treatment: Immediate care & First week after treatment C- Vit serum / Lotion + Factor G Lotion + Moisturizing pack Sun screen Away from excessive heat stimulus such as sauna, hot spa

Post-Care Treatment [Medical examination and treatment after 1 week www.sellaslaser.com [Medical examination and treatment after 1 week Restart skin care at home Skin Healing or tighten mask as for cosmetic care (propymask, Biomask) [Post CIS-F1 treatment]: Second week after treatment Return to regular skin care: C-Vit Lotion + Factor G lotion (scars) RetiseS / Fillderma System (aging), C-Vit DaeSeS (DMAE) for flaccidity Kojic acid / Alfa lipoic / arbutin (bleaching) JuveSeS Teens / SaliSeS(acne) [Medical examination and treatment after 2 weeks]: Combine treatments Start aesthetic treatment with chemical peel, IPL, RF, Microdermabrasion, electroporation for complementary approach (Antiaging, Whitening, Tightening) [Second visit for CIS-F1 treatment after 4 weeks]

Contraindication for Sellas www.sellaslaser.com Renal failure 2. Herpes simplex 3. Acute infection 4.Post thermal injury

Fast high density delivery Advantages www.sellaslaser.com Fast high density delivery Able to tailor stamping shape according to lesional shape Thermal peeling Only Sellas can represent “True” 2nd generation fractional laser!

PHOTOS (BEFORE/AFTER) Terminology of Laser www.sellaslaser.com PHOTOS (BEFORE/AFTER)

Skin Photo Gallery www.sellaslaser.com Patient age: 28 (Skin type: IV) After 3 Tx

Skin Photo Gallery www.sellaslaser.com Patient age: 27 (Skin type: IV) After 3 Tx

Skin Photo Gallery www.sellaslaser.com Patient age: 27 (Skin type: IV) After 3 Tx

Skin Photo Gallery www.sellaslaser.com Patient age: 29 (Skin type: IV) After 5 Tx

Skin Photo Gallery www.sellaslaser.com Patient age: 32 (Skin type: IV) After 3 Tx

Skin Photo Gallery www.sellaslaser.com Patient age: 32 (Skin type: IV) After 3 Tx Patient age: 46 (Skin type: IV) After 3 Tx

Skin Photo Gallery www.sellaslaser.com Patient age: 25 (Skin type: IV) After 3 Tx

The 2nd Generation of Fractional Ablative Tx. With CIS-F1 www.sellaslaser.com Thank you. The 2nd Generation of Fractional Ablative Tx. With CIS-F1 ®