ABIRD: Active Background Ion Reduction Device for nanospray ESI By John Neveu ESI Source Solutions, LLC Woburn, MA USA ESI Source Solutions.

Slides:

Advertisements

Similar presentations

Details of Tune and Method Setup for LTQ Orbitrap

Advertisements

Forensic Drug Testing Part 2: GC/MS Confirmation

D e t e c t o r s f o r H P L C.

What is it? What is e-BRIDGE Job Point?  e-BRIDGE Job Point is a utility that shares the load of a large print job across multiple e-STUDIO MFD’s. Harness.

1. Four LLs were published in February Transmission Relaying – Undesired Blocking 2.Lack of Separation for Critical Control Power Supply Leads.

FC-MS from Teledyne Isco CombiFlash ® a Name You Can Rely On.

Chem. 133 – 2/19 Lecture. Announcements Lab Work –Turn in Electronics Lab –Starting Set 2 HW1.2 Due Today Quiz 2 Today Today’s Lecture –Noise –Electrochemistry.

I n t e g r i t y - S e r v i c e - E x c e l l e n c e Headquarters U.S. Air Force 1 Direct Sampling Ion Trap Mass Spectrometry Rob R. Smith Oak Ridge.

COMPARATIVE STUDY OF THE ADSORPTION PERFORMANCE OF A MULTI- SORBENT BED (CARBOTRAP, CARBOPACK X, CARBOXEN 569) AND A RADIELLO ® ADSORBENT TUBE FOR THE.

picoSpin 45 & 80 Product Overview

Mass Spectroscopy Quantitative Chemical Analysis Harris, 6th Edition

LC/MS WORKSHOP IOWA STATE UNIVERSITY Kamel Harrata  Instrument Description  Data Acquisition  Data Processing.

Instant Notes Analytical Chemistry

FIGURE 5. Plot of peptide charge state ratios. Quality Control Concept Figure 6 shows a concept for the implementation of quality control as system suitability.

A Company Selling Technology and not just a Product.

Waters Corporation Connecting Data to Decisions John Swallow Principal Engineer Waters Data Products

Contents 1.What is MATRIX Mobile 2.Menu Options 3.Installation 4.Access.

Emco High Voltage DC to DC Converters BY John Kmiec.

SEEKING INVESTORS Investment Opportunity LPG and Butane Gas Engine Conversion Kits.

Quantitative Insulin Analysis Using Liquid Chromatography–Tandem Mass Spectrometry in a High- Throughput Clinical Laboratory Z. Chen, M.P. Caulfield, M.J.

William Kou Jonathan Mertz. Introduction The field of Mass Spectrometry using Ambient Ionization techniques has grown exponentially since The direct.

Untargeted Metabolomics: Tandem LC-MSMS. Column and Flow Rate Selection Insert Barnes table for flow rates and sensitivity gain. Reverse Phase and Normal.

Instrumentation Overview Spring 2012 The laboratory is a controlled environment where we can measure isolated physical phenomena with a view to eventual.

Mike Rusak and Laura Fairburn CURRENT OBSTACLES ON THE APPLICATION OF AMBIENT IONIZATION MS IN FORENSICS.

Gas Chromatography Experiment. Gas Chromatography - Gas Chromatography (GC) is a common technique used to separate and identify volatile organic compounds.

The Theory of Near Light Scatter

CHEM*3440 Operational Amplifiers These integrated circuits form the backbone of modern instrumental methods. Understanding their operation will help you.

Improving the Detection of Hydrophilic Peptides for Increased Protein Sequence Coverage and Enhanced Proteomic Analyses Brian S. Hampton 1 and Amos H.

Ambient mass spectrometry using Desorption Electrospray Ionization (DESI) Farzad Fani Pakdel Group meeting Thursday March 23, 2006.

This project is funded by the NSF through grant PHY , and the Universities of JINA. The Joint Institute for Nuclear Astrophysics Henderson DUSEL.

1 CH908 Structural Analysis by Mass Spectrometry revision lecture. Prof. Peter O’Connor.

Salamanca, March 16th 2010 Participants: Laboratori de Proteomica-HUVH Servicio de Proteómica-CNB-CSIC Participants: Laboratori de Proteomica-HUVH Servicio.

Metabolomics MS and Data Analysis PCB 5530 Tom Niehaus Fall 2015.

Chem. 133 – 2/18 Lecture. Announcements Homework Set 1.2 (bold problems) – due today Quiz 2 Today Electronics Lab Reports – due Tuesday Seminar this Friday.

CHEMICAL COMPOSUTION OF ORGANIC AEROSOL EXPLORED BY TD-PTR-MS Rupert Holzinger, Joseph Timkovsky, Beatriz Oyama, Niels van Elst, Patrick Schlag, Ulrike.

The world leader in serving science For Research Use Only. Not for use in diagnostic procedures Quantitative Analysis of 4 Immunosuppressant Drugs in Whole.

Universal IR Controller -- Home Automation. Universal IR Controller Features 360° full range IR launch Wifi, RF communication Remote control Delicate.

Forensic Toxicology Use Only Analysis of ETG, ETS using the Thermo Scientific Exactive Mass Spectrometer Kent Johnson Fortes lab, Portland Oregon.

The Syllabus. The Syllabus Safety First !!! Students will not be allowed into the lab without proper attire. Proper attire is designed for your protection.

Clinical Research Use Only Not For Diagnostic Purposes

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Vehicle Search Script | Logistics Booking Script from I-Netsolution.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

ACROSS THE WORLD MCAFEE PROVIDING THE UPDATE PROTECTION SOLUTIONS TO THE COMPUTER USERS. AS SAME TO THE ERROR ABOVE, WAIT FOR FEW MINUTES AND THINK SOME.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

ACROSS THE WORLD MCAFEE PROVIDING THE UPDATE PROTECTION SOLUTIONS TO THE COMPUTER USERS. AS SAME TO THE ERROR ABOVE, WAIT FOR FEW MINUTES AND THINK SOME.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Across the world McAfee providing the update protection solutions to the computer users. As same to the error above, wait for few minutes and think some.

Data Fusion Market

Chem. 133 – 2/16 Lecture.

The NEW HeatWave nanospray source

Best Practices for Identification and Quantitation

Schematic of MS1 filtering.

Is Proteomics the New Genomics?

Mass spectrometry (MS) is an analytical technique that can be used to determine the mass, elemental composition or chemical structure of molecules. Mass.

Presentation transcript:

ABIRD: Active Background Ion Reduction Device for nanospray ESI By John Neveu ESI Source Solutions, LLC Woburn, MA USA ESI Source Solutions

Nanospray ESI (n-ESI) is a common technique for interfacing capillary chromatography systems with a mass spectrometer. n-ESI is typically done without supplied gas, leaving the background ion signal subject to variable ambient laboratory air conditions. ESI Source Solutions

ABIRD works by treating the ambient lab air, which is then directed to the n-ESI spray formation zone in an open source.

ABIRD also works by treating the ambient lab air which then displaces untreated air in a semi closed source. ESI Source Solutions

Typical Orbitrap full MS no ABIRD 7.59e5 Typical Orbitrap full MS with ABIRD. 5.00e4 ABIRD on an Orbitrap shows greater than a 10x reduction in background ions when operating. ESI Source Solutions

ABIRD installed on an LTQ shows 10x reduction in background ion signal. 2.36e3 Typical LTQ full MS with ABIRD. Typical LTQ full MS no ABIRD 2.38e4 ESI Source Solutions

Left panel: 5 min chromatogram BP Da, ABIRD on then off and then on again. Right panel, top: 1min summed spectra, ABIRD off, TIC 1.27E6 Right panel, bottom: 1 min summed spectra, ABIRD on, TIC 4.6E4 ESI Source Solutions Typical ABIRD behavior on a typical day.

ABIRD significantly improves signal to noise and signal stability across a chromatographic run. No ABIRD With ABIRD

ABIRD Installations these from our EU distributor MS Wil more here:

ABIRD device in place on LTQ-Orbitrap with a New Objective Picoview source:

Joint Marketing Agreement with Thermo Scientific on the use of ABIRD on Thermo nanospray sources. Thermo Fisher Scientific and ESI Source Solutions have agreed that: ABIRD has been configured and tested with Thermo Scientific™ nano-electrospray ion sources: EASY- Spray™, Nanospray Flex™ and Nanospray-II, and is fully compatible with these sources. The benefits of ABIRD are simple: ABIRD isolates the inlet from changing background ions, which is critical for extended quantitative or comparative analyses. ABIRD reduces background ions, enhancing S/N ratio quite dramatically in many cases We look forward to promoting ABIRD on Thermo Scientific instruments worldwide!

Summary: ABIRD imparts a controlled low level background ion signal to nanospray ESI mass spectrometers across a wide mass range. ABIRD protects the instrument from ambient spikes in laboratory air quality, crucial for quantitative analysis. Installation solutions are available for almost any nanospray source on the market, including DIY’er kits. ABIRD is a smart addition to any nanospray source. Many more details at company website of: