The Complement Cascade

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Presentation transcript:

The Complement Cascade The Classical Pathway Next

Complement: The Classical Pathway C1q Ab Ag C1q binds to antibody/antigen complex Antibody binds to antigen Next

Complement: The Classical Pathway C1q-Ab-Ag

Complement: The Classical Pathway C1q-Ab-Ag C1q/antibody/antigen complex activates C1r (bound to C1s) C1r-C1s C1r-C1s Next

Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag Activated C1r cleaves C1r/C1s, releasing Active C1s C1s Next

Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1s C1s cleaves C4 C4 to C4a and C4b C4a C4b Next

Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C1s C4 C4b C4b.2 C2 C4a C4b binds to C2 Next

Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C4b.2b C2a producing C4b.2b and C2a C1s cleaves C2 C1s C4 C4b.2 C4a Next

Complement: The Classical Pathway C4b.2b is termed the Classical C3 Convertase C4b.2b cleaves C3 to produce C3b (C3a is released) C3b is the first molecule of the Terminal Pathway Next

Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag Cb4.2b cleaves C3 C4b.2b C2a C1s C3a C3b producing C3a and C3b C4b.2 C4 C4a (Click Here)

Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C4b.2b C2a C1s C3a C4 C4b.2 C4a C3b C5b C5a C5

Complement: The Classical Pathway C1r-C1s C1q-Ab-Ag C4b.2b C2a C1s C3a C4 C4b.2 C4a C3b C5b.6.7.8 C5b.6.7 C5b.6 C5b C5a C5 C8 C7 C6 C9n C5b.6.7.8.9n

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