Industrial Careers Expo Dr Heather Bryson 10 October 2012 University of Sheffield

Project Leader, Director Key Deliverables -Lead R&D projects from Lead Optimisation Investment Decision to End of Phase 2 Development Responsible for project strategy, TPP and delivery Ensuring alignment with the project strategy to the disease area strategy Interfacing and positioning of project within the broader business context Pro-active in cross project and disease area learnings Ensure appropriate resourcing of international project teams -Seek and apply best practices in processes, data analysis, and decision-making in the project team -Ensure that assets of the project are developed, managed and protected -Ensure that the project team is appropriately resourced; ensure resources from functions are managed effectively in the project team -Ensure that there are robust processes, plans and data to enable Governance Bodies to make investment decisions and prioritise projects across the portfolio -Accountable for the delivery of project according to quality, time, budgets and resources New Opportunities iMED, AstraZeneca 2 H Bryson | 12 Oct 2012

Project Leader, Director Culture -Create a vibrant, entrepreneurial and externally facing team focused on the delivery of successful PoCs that supports courageous leadership, innovation and collaboration, such that the Project team is open to challenge, new ideas, innovative ways of working, and where continuous learning and improvements are driven -Collaboration to embed best practice Talent Management & Development -Provide feedback and coaching to deployed reports and mentor key talent in the organization Contributions: -Support development of a winning disease area strategy, driving portfolio value -Share responsibility for iMed DA strategy, and the delivery of successful POP/POC, demonstrating therapeutic relevance, with high probability of successful market access and delivery of valuable new medicines New Opportunities iMED, AstraZeneca 3 H Bryson | 12 Oct 2012

Project Leader, Director A Day in the Life H Bryson | 12 Oct 2012

Project Leader, Director Finalization of slides for presentation to leadership team (Project A) Agree strategy and items for endorsement Review of development strategy with Project Team (Project B) Recommendation to progress lead CD vs. back-up -Meet with clinical team (Project C) for ongoing study recruitment update -Cross iMED meeting - repositioning assets & DA strategy Parallel development strategy; target indications & benefit:risk assessment - Review and discussion of external opportunity Development of business case – TPP and financials -1:1 Project Team interactions Project updates; issues to be addressed -External KOL discussion (Project D) Scientific rationale and potential clinical development plan -Inevitable late call from US colleagues….change in strategy/additional development options for consideration (Project A) Re-visit leadership team presentation….. A Day in the Life H Bryson | 12 Oct 2012

Project Leader, Director Education Advanced degree in life sciences, MD and/or PhD or equivalent Experience 5-10 years of work experience in discovery or development settings Experience of working with projects in discovery and development setting Experience of decision making and leadership in a cross- disciplinary/functional, cross-cultural environment Experience in either science, clinical or drug development Awareness of scientific as well as commercial/payer, regulatory and broader strategic aspects Practical experience in working on teams in the discovery and development settings Strong project management expertise Proven leadership skills in managing projects Minimum Requirements – Education and Experience 6 H Bryson | 12 Oct 2012

Project Leader, Director Passion for Customers -Manage multiple customer needs -Apply long-term customer insight Think Strategically -Develop appropriate plans Act Decisively -Create clarity for others to make decisions and demonstrate courage to support decisions Drive Performance -Anticipate and remove obstacles for others -Generate step change in performance of team Work Collaboratively -Create shared purpose across boundaries -Address blockers to effective collaboration Develop People and Organisation -Build organisational capability Skills and Capabilities 7 H Bryson | 12 Oct 2012

Ph.D. Research Strategic thinking -Plans to address a scientific question -PhD research proposal Spoken and Written Communication -Scientific presentations and publications Decision Making Time management and prioritisation Global network -Collaborations/interactions Review and interpretation of scientific literature Analytical skills Requirement for innovation due to limited funds available Review of options (pros and cons/ answering key questions) Skills & Capabilities 8 H Bryson | 12 Oct 2012

Pharmaceutical Career vs. Academic Research Potential to develop broader expertise -Application of knowledge and skills to broader areas Unmet medical need & interesting science vs. real; world hurdles -Appreciation of regulatory, pricing and reimbursement environments driving business decisions Limited chance of seeing development through to market Changes in DA strategy with impact on projects/targets -Managing upwards/securing resource/changing the paradigm Limited funding – pharmaceutical and academic Broader network of expertise Increased scope for change to career path Pros and Cons 9 H Bryson | 12 Oct 2012

Career Path & Career Progression Wide range of career paths/options available -Bench scientist vs office environment “Virtual” working model…. -Clinical Operations -CRA -Clinical Pharmacology and Drug Metabolism & PharmacoKinetics -Project Management -Project Leadership -Bioanalytics -Regulatory -Commercial -Sales and Marketing -Payer Evidence -Safety Assessment -Pharmacovigilance -Translational Science -PHC …..to name a few 10 H Bryson | 12 Oct 2012 SB/GSK – Clinical Development Director (10 yrs) Eisai – Clinical Development Director (1 yr) AstraZeneca – Director, Project Leader (3 yrs)

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