FcɛRI Signalling Pathway. The Ligand : IgE Mast and Basophil Cells.

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Presentation transcript:

FcɛRI Signalling Pathway

The Ligand : IgE

Mast and Basophil Cells

Fc receptors bind tail region of IgE antibodies. Histamine, proteases,

The Receptor

Tyrosine Kinases Lyn Syk

The Pathway Binding of IgE Aggregation of receptors

Syk activationCascade of reactionsDegranulation Lyn binds beta unit of one receptor and transphosphorylates the beta ITAM, gamma ITAM, and Syk associated with adjacent receptor. Syk can also phosphorylate syk associated with adjacent receptor

Allergy sufferers are at a lower risk of developing cancer

Inverse association between IgE and malignancies IgE-mediated immune responses against tumor cells IgE-based treatment options

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