Circulación Cerebral y Demencia Senil

Interactions between VaD and AD VaD post-stroke dementia infarcts, white matter lesions (WMLs) vascular risk factors VaD+AD Source: G Roman San Antonio TX Pure AD Pure VaD “ mixed ”

Iason Pratensis (Jason de Pratis) published in Basle (1549) the first textbook of neurology De Cerebri Morbis It included a chapter on dementia De memoriae detrimento Pestronk A. The first neurology book. De Cerebri Morbis...(1549) by Jason Pratensis. Arch Neurol 1988 Mar;45(3):341-4.

1 st description of post-apoplectic dementia: “Dullness of mind and forgetfulness and then afterwards …a stupidity and foolishness. In many, stupidity has accompanied the palsie or has gone before apoplexy” De Anima Brutorum 1672 Thomas Willis at age 45 (1667) In Willis' time, the word foolishness (stultitia in Latin, from stultus foolish, meaning "to be of unsound mind") was equivalent to dementia

Th. Willis Dementia Post-apoplexy Binswanger, Alzheimer Vascular Dementia Kraepelin Arteriosclerotic Dementia Senile & Presenile AD DSM-I Chronic Brain Syndrome Hachinski Scale Roman Vascular Dementia Erkinjuntti Cortical vs. Subcortical Roman NINDS- AIREN Criteria DSM IV- Executive Dysfunction Katzman: AD is the Main Cause of Atrophy and Dementia DSM-III MID NINDS- ADRDA Criteria for AD VaD VCD VCI AD VaD DEMENTIADEMENTIA Pathological reports of Alzheimer’s disease CADASIL 1 st genetic form of VaD 2012 A BRIEF HISTORY OF DEMENTIA

Cerebral circulation Coronary circulation Source: S Salloway

Professor of Chemistry, Lille Director École Normale Supérieure, Paris Silkworm diseases 19 Oct 1868 First stroke, L hemiplegia (Age 46) Pasteur at his laboratory working on the rabies vaccine (portrait by Edelfelt). LOUIS PASTEUR ( )

Pasteur: Left hemiparesis

Professor of Chemistry, Lille École Normale Supérieure, Paris Silkworm diseases 19 Oct 1868 First stroke, L hemiplegia (Age 46) Studies on fermentation and beer Anthrax, fowl cholera Rabies vaccine Oct nd stroke (Age 65) rd stroke (Age 72) LOUIS PASTEUR ( )

“Common Sense” Reisch Margarita Philosophica (1513)

Snowdon D, et al. JAMA March 12, 1997; 277(10):

Concept-changing factors Progress in the neurosciences Neuroimaging Neuropathology Cerebral Blood Flow Neuropsychology Frontal Lobe Genetics Epidemiology Pharmacology

special article Vascular dementia: Diagnostic criteria for research studies Report of the NINDS-AIREN International Workshop GC Román, TK Tatemichi, T Erkinjuntti, JL Cummings, J Masdeu, JH García, L Amaducci, J-M Orgogozo, A Brun, A Hofman, DM Moody, MD O’Brien, T Yamaguchi, J Grafman, BP Drayer, DA Bennett, M Fisher, J Ogata, E Kokmen, F Bermejo, PA Wolf, PB Gorelick, KL Bick, AK Pajeau, MA Bell, C DeCarli, A Culebras, AD Korczyn, J Bogousslavsky, A Hartmann, and P Scheinberg NEUROLOGY 1993;43:

NINDS-AIREN International Workshop on Vascular Dementia; April 19-21, 1991; NIH Campus, Bethesda, Md NINDS/CSN Workshop Bethesda 2005