Overview of the Chemical Threat Laboratory of Texas William Edgemond, Ph.D. Texas Department of State Health Services October 2013
Course Objectives Introduction and Background Who We Are What We Can Do What We Want You to Do
Chemical Threats
Laboratory Response Network International network of laboratories to respond quickly to high priority public health emergencies, such as biological, chemical, and radiological threats, through training, rapid testing, timely notification and secure messaging of laboratory results.
LRN-C Structure CDC Level 1 10 Labs Level 2 & Level 3 Activities National Surge Capacity Core Methods & Add’l Methods Additional Personal & Instruments Level 2 34 Labs Level 3 Activities Core Methods State/Local Response Capacity Level 3 9 Labs Competency in collecting and shipping clinical samples Comprehensive response plan
US Chemical Threat Labs Level 1 Level 3 Level 2
Course Objectives Introduction and Background Who We Are What We Can Do What We Want You to Do
Personnel Dr. Bill Edgemond Team Lead/Chemical Threat Coordinator Jim Barnes Chemist Jocelyn Hover-Jeansonne Chemist
How We Will Respond Can easily handle a large number of samples utilizing Lab Check-in personnel and space
Types of Samples Clinical Samples Blood Urine Environmental/White Powders
Clincal Methods CAP/CLIA Accredited Lab 11 Methods Developed by CDC 3 GC/MS Methods 4 LC-MS/MS Methods 3 ICP-MS Methods 1 LC-ICP-MS Methods
Instrumentation & Capabilities Biosafety L2 Hood Chemical Hoods Automated Liquid Handler Bar Code Reader LIMS
GC-MS Cyanide in Blood Volatile Organic Compounds in Blood Tetramine in Urine
ICP-MS Cadmium, Lead, & Mercury in Blood Trace Elements in Urine (Be, Co, Mo, Cd, Sb, Cs, Ba, W, Pt, Tl, Pb, U) Arsenic & Selenium LC-MS-ICP Lewisite (Chlorovinyl arsonous acid)
LC-MS/MS Abrine/Ricinine Organophosphorous Nerve Agent Metabolites Tetranitromethane Metabolite (HNPAA) Monofluoroacetate/ Monchloroacetate
Unknowns/White Powders Typical submitted by FBI Cleared by Bio Threat Classify type of compound
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Unknowns/White Powders FT-IR FT-IR Microscope XRF Geiger Counter Volatiles Detector Wet Chemistry Tools
CT Lab Contact Info —Direct Lab Phone. —24-hour Emergency Phone. – Chemical Threat Coordinator -- DSHS Chemical Emergency Website -- CDC Chemical Emergency Website
Texas CT Lab
Questions