World population: 6.7 billion Global Prevalence Patients per million population (p.m.p.) Global View of ESRD Patients World population 1.2% ESRD~ 7% Haemodialysis7-8% Peritoneal Dialysis ~ 7% Transplants ~ 6% Growth Rates ESRD Patients 2,310,000  thereof Dialysis 1,775,000(77%) HD 1,585,000(69%) PD 190,000 (8%)  thereof Transplants535,000 (23%) Global Prevalence Development Dialysis patients per million population (p.m.p.)

Patient Numbers thousands estimation 1,775,000 Dialysis Patients EU 17% Japan 16% Other 46% USA 21% HD - PD Split HD 89% PD 11% Global View of Dialysis Patients USA % EU % Japan % Other % Total ~ 7 % Growth Rates Source: FME Market and Competitor Survey, % 20% 21% 25% 46% 16% 17% 21% 49% 15% 16% 20%

Country (millions)population Dialysis (thousands) % of total patients Dialysis prevalence (p.m.p.) Global6,7401, Population% of worldpatientsdialysis USA3055%37121%21%1,215 Japan1272%28716%2,250 Germany821%764%925 Brazil1983%885%450 China1,33420%945%70 Countries ,71725%40723%235 Countries ,79241%45226%160 Countries %00%0 Relative Population Profiles