Age (years) Gender (Males), n (%) Dialysis duration (years) Hemoglobin (mg / dl) Pre dialysis SBP (mmHg) Pre dialysis DBP(mmHg) Post dialysis SBP (mmHg) Post dialysis DBP (mmHg) SBP (mmHg) DBP (mmHg) Hypertension, n (%) Use of antihypertensive agents, n (%) Interdialytic body weight gain (%) Diabetes mellitus, n (%) Total cholesterol (mg / dl) Triglycerides (mg / dl) HDL cholesterol (mg / dl) Dyslipidemia, n (%) Ischemic heart disease, n (%) Current smoking, n (%) Serum albumin (g / dl) C-reactive protein (mg / dl) Use of antithrombotic agents, n (%) Prevalence of CMBs, n (%) Table 1. Characteristics of patients with and without CMBs, and healthy subjects a 55.2 ± (64.2%) 7.6 ± ± ± ± ± ± (82.8 %) 96 (71.6 %) 4.2 ± (26.1 %) ± ± ± (46.3 %) 44 (32.8 %) 29 (21.6 %) 3.8 ± ± (38.1 %) --- Without CMBs (n=134)With CMBs (n=45) 67.1 ± (62.2%) 5.9 ± ± ± ± ± ± (95.6 %) 38 (84.4 %) 3.8 ± (44.4 %) ± ± ± (53.3 %) 16 (35.6 %) 10 (22.2 %) 3.7 ± ± (42.2 %) --- P Value b < NS < NS NS NS NS --- CMBs, cerebral microbleeds; SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL, high density lipoprotein; PVH, periventricular hyperintensity; DSWMH, deep and subcortical white matter hyperintensity. a Plus-minus values are mean ± SD, b without CMBs versus with CMBs 58.2 ± (63.7%) 7.2 ± ± ± ± ± ± (86.0 %) 134 (74.9 %) 4.1 ± (30.7 %) ± ± ± (48.0 %) 60 (33.5 %) 39 (21.8 %) 3.8 ± ± (39.1 %) 45 (25.1 %) Total (n=179) Healthy subjects (n=58) 55.9 ± (53.4%) ± ± ± (17.2 %) 3 (5.2 %) (1.7 %) ± ± ± (43.1 %) 0 (0 %) 10 (17.2 %) 4.2 ± ± (0 %)

Variable Age 1 year Gender Dialysis duration 1 year Pre dialysis systolic blood pressure 1 mmHg Pre dialysis diastolic blood pressure 1 mmHg Post dialysis systolic blood pressure 1 mmHg Post dialysis diastolic blood pressure 1 mmHg Hypertension Use of antihypertensive agents Interdialytic body weight gain 1 % Diabetes mellitus Dyslipidemia Ischemic heart disease Current smoking Serum albumin 1 g / dl C-reactive protein 1 mg / dl Hemoglobin 1 g / dl Use of antithrombotic agents Univariate P Odds Ratio (95% CI) Unit Increase ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) < Table 2. Univariate logistic regression analysis of factors associated with CMBs Dummy variables were entered for gender (female = 0, male = 1), presence of CMBs (absent = 0, present = 1), hypertension (absent = 0, present = 1), diabetes mellitus (absent = 0, present = 1), dyslipidemia (absent = 0, present = 1), ischemic heart disease (absent = 0, present = 1), current smoking (non-smoker = 0, smoker = 1), use of antihypertensive agents (no = 0, yes = 1) and antithrombotic agents (no = 0, yes = 1).

Variable Model 1Model 2 Table 3. Multiple logistic regression analysis of factors associated with CMBs Odds Ratio (95% CI) Unit Increase Dummy variables were entered for gender (female = 0, male = 1), presence of CMBs (absent = 0, present = 1), diabetes mellitus (absent = 0, present = 1), dyslipidemia (absent = 0, present = 1), ischemic heart disease (absent = 0, present = 1), current smoking (non-smoker = 0, smoker = 1), hypertension (absent = 0, present = 1) and use of antithrombotic agents (no = 0, yes = 1). R 2 ; coefficient of determination. **** P < , ***P < 0.001, * *P < 0.01, * P < 0.05 R2R2 Model 3 Odds Ratio (95% CI) Age 1 year Gender Dialysis duration 1 year Diabetes mellitus Dyslipidemia Ischemic heart disease Current smoking Serum albumin 1 g / dl C-reactive protein 1 mg / dl Hemoglobin 1 g / dl Use of antithrombotic agents Interdialytic body weight gain 1 % Pre dialysis systolic blood pressure 1 mmHg Pre dialysis diastolic blood pressure 1 mmHg Hypertension ****( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) 1.037***( ) **** ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ** ( ) ****( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) 0.237****0.214****0.186***

Variable Model 4Model 5 Table 4. Multiple logistic regression analysis of factors associated with CMBs Odds Ratio (95% CI) Unit Increase Dummy variables were entered for gender (female = 0, male = 1), presence of CMBs (absent = 0, present = 1), diabetes mellitus (absent = 0, present = 1), dyslipidemia (absent = 0, present = 1), ischemic heart disease (absent = 0, present = 1), current smoking (non-smoker = 0, smoker = 1), hypertension (absent = 0, present = 1), use of antithrombotic agents (no = 0, yes = 1) and antihypertensive agents (no = 0, yes = 1). R 2 ; coefficient of determination. **** P < , ***P < 0.001, * *P < 0.01, * P < 0.05 R2R2 Model 6 Odds Ratio (95% CI) Age 1 year Gender Dialysis duration 1 year Diabetes mellitus Dyslipidemia Ischemic heart disease Current smoking Serum albumin 1 g / dl C-reactive protein 1 mg / dl Hemoglobin 1 g / dl Use of antithrombotic agents Interdialytic body weight gain 1 % Post dialysis systolic blood pressure 1 mmHg Post dialysis diastolic blood pressure 1 mmHg Use of antihypertensive agents ****( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) 1.023*( ) **** ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ** ( ) ****( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ) 0.206****0.214****0.190***

Lacunar infarcts, n (%) PVH, n (%) DSWMH, n (%) Table 5. Prevalence of cerebral small-vessel diseases with and without CMBs 45 (33.6 ) 41 (30.6 ) 49 (36.6 ) Without CMBs (n=134)With CMBs (n=45) 29 (64.4 ) 38 (84.4 ) 35 (77.8 ) P Value a < CMBs, cerebral microbleeds; PVH, periventricular hyperintensity; DSWMH, deep and subcortical white matter hyperintensity. a without CMBs versus with CMBs 74 (41.3 ) 79 (44.1 ) 84 (46.9 ) Total (n=179)

Variable Lacunar infarcts PVH DSWMH PP.1921 < Odds Ratio (95% CI) ( ) ( ) ( ).0004 <.0001 CMBs, cerebral microbleeds; PVH, periventricular hyperintensity; DSWMH, deep and subcortical white matter hyperintensity; 95% CI, 95% confidence interval. Dummy variables were entered for presence of CMBs (absent = 0, present = 1), lacunar infarcts (absent = 0, present = 1), PVH (absent = 0, present = 1 and DSWMH (absent = 0, present = 1). *Adjusted by age and gender ( ) ( ) ( ) Table 6. Correlations between CMBs and other cerebral small-vessel diseases UnadjustedAdjusted*