© ANZDATA Registry CANCER CHAPTER CHAPTER 10

© ANZDATA Registry CharacteristicMyelomaNon-Myeloma n%n% Total (%)807153,37199 Country of residence Australia ,25683 New Zealand117159,11517 Primary renal disease Myeloma Potentially Myeloma related Glomerulonephritis/IgA nephropathy35415,90630 Diabetes24312,72824 Other65824,12945 Age at ESKD < , , , ,73211 Sex Female ,48242 Male ,88958 Era of ESKD < , , , , ,66226 First Dialysis modality Haemodialysis ,53968 Peritoneal dialysis ,83232 Racial background Non-white47611,79222 White ,57978 Other malignancy prior to ESKD None ,68293 Pre-dialysis malignancy6483,6897 Other malignancy subsequent to ESKD None ,76691 Post-dialysis malignancy2134,6059 Smoking history at ESKD Never or unknown ,66759 Current or former ,70441 Diabetes Mellitus No ,82869 Yes131168,18815 Unknown *87118,35516 Status during follow-up Alive ,14940 Died , Table 1: Characteristics of people with and without myeloma treated by dialysis between

© ANZDATA Registry Figure 1: Plot of myeloma diagnosis relative to timing of ESKD and dialysis commencement

© ANZDATA Registry Figure 2a: Unadjusted survival on dialysis for myeloma versus non myeloma patients

© ANZDATA Registry Figure 2b Unadjusted survival on dialysis, stratified by primary renal disease

© ANZDATA Registry Era of dialysis MyelomaNon-myeloma NMedian (IQR)NMedian age (IQR) < ( )12, ( ) ( )6, ( ) ( )9, ( ) ( )11, ( ) ( )13, ( ) Table 2: Average age of people starting dialysis through time

© ANZDATA Registry Cause of death Myeloma Total deaths 609 Non myeloma Total deaths 32, 223 N (%) Cardiovascular102 (14.8)12, 842 (39.9) Vascular23 (3.3)3, 478 (10.8) Infection70 (10.1)4, 785 (14.9) Cancer383 (55.5)2, 739 (8.5) Social99 (14.4)5, 934 (18.4) Other13 (1.9) 2, 445 (7.6) Table 3: Cause of death for people on dialysis with and without myeloma in Australia and New Zealand *

© ANZDATA Registry Figure 3: Unadjusted survival on dialysis for people with (MM) and without myeloma (non- MM), by age at starting dialysis and stratified by era of treatment *

© ANZDATA Registry Univariate Multivariate CharacteristicHazard ratio (95% CI) P for difference Hazard ratio (95% CI) P for difference Primary renal disease Myeloma (referent) Potentially Myeloma related0.7 ( ) 0.6 ( ) Glomerulonephritis/IgA nephropathy 0.7 ( ) 0.7 ( ) Diabetes0.7 ( ) 0.7 ( ) Other0.6 ( ) 0.6 ( ) Age <55(referent)1.0< < ( ) 0.9 ( ) ( ) 1.6 ( ) ( ) 1.7 ( ) Sex Female (referent) Male1.0 ( ) Era of dialysis <1990 (referent) ( ) ( ) ( ) ( ) Timing of myeloma diagnosis relative to ESKD > 5 years before ESKD (referent) years before ESKD1.1 ( ) 1-11 months before ESKD1.3 ( ) Peri ESKD (within 1 month before or after ESKD) 1.3 ( ) 1-12 months after ESKD1.1 ( ) First Dialysis modality Haemodialysis (referent) Peritoneal dialysis0.8 ( ) 0.7 ( ) Racial background Non-white (referent) White0.9 ( ) Other malignancy prior to ESKD None (referent) Pre-dialysis malignancy0.9 ( ) Smoking history at ESKD Never (referent) Current or former0.9 ( ) Diabetes at ESKD No diabetes (referent) <0.001 Diabetes1.4 ( ) 1.5 ( ) Table 4: Risk of death for people with myeloma treated with dialysis in Australia and New Zealand