Surgical Neonatal Vomiting

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Presentation transcript:

Surgical Neonatal Vomiting Jonathan Wells Bristol Children’s Hospital 2nd August 2013

Interactive Case studies Summary of specific surgical conditions

What is a neonate? What is preterm? What is term?

Definitions Neonate – premature and term babies less that 44 weeks post-conceptional age Premature neonate <37 weeks post-conceptional age Term neonate 37-40 weeks post-conceptional age Post term >40 weeks post-conceptional age

History and Symptoms

History and Symptoms Gestation Weight Antenatal history Colour of vomit Frequency of vomit Bowel opening Saliva? Associated co-morbidities

Physical Findings

Physical findings Observations Erythema and bruising Distended Scaphoid abdomen Mass Anus – site, size and patency Tenderness External genitalia – normal? Palpable testes? Inguinal hernia

Investigations Plain AXR/CXR Upper/Lower GI contrast Abdominal USS

Case 1 Term neonate 1 day old Vomiting Relevant points in history Relevant examination findings Differential diagnosis

Oesophageal atresia and tracheo-oesophageal fistula 1 in 3500 liveborn births Antenatal Polyhydramnios, absent stomach, associated anomalies Salivation, cyanosis on feeding Inability to pass NGT Associated anomalies: Vertebral – butterfly vertebra, rib anomalies Anorectal Cardiac – Tetralogy of Fallot, AVSD, ASD, VSD etc Tracheo-oesophageal fistula Esophageal atresia Renal – dyeplasia, agenesis and other defects Limb – radial ray defects

Classification Type A: 8%, Type B: 1%, Type C: 86%, Type D 1%, Type E: 4%

Repair Right thoracotomy (usually) 4th or 5th intercoastal space Extrapleural approach +/- division of azygous vein Identification of TOF Transfixion and division Identification of upper pouch End to end full thickness anastomosis Transanastomotic tube +/- post op contrast study

Duodenal Atresia 1 in 5000 Antenatal diagnosis – ‘double bubble’ Associated with Trisomy 21 - 30%, malrotation Milky or bilious vomiting depending on level of obstruction in relation to bile duct 85% obstruction distal to bile duct Side to side duodenoduodenostomy

Malrotation +/- volvulus

Malrotation 1 in 6000 present in babies Abnormal duodenal loop 0.5% of autopsies show degree of malrotation Abnormal duodenal loop Narrow mesentery Peritoneal band ‘Ladds’ bands from caecum to lateral abdominal wall Clockwise torsion of entire midgut

Malrotation + volvulus SURGICAL EMERGENCY Bilious vomiting in neonate Upper GI contrast to diagnose Emergency laparotomy to devolve bowel counterclockwise Total gut necrosis – life threatening

Jejunal/Ileal atresia Stenosis – 11% Type 1 – 23% Type 2 – 10% Type 3 – 35% Type 4 – 21%

Jejunal/ileal atresia 1 in 5000 births Aetiology – antenatal vascular compromise May have short bowel Resection and anastomosis May be multiple May require tapering May be end to end or end to side depending on discrepancy

Meconium Ileus CF – 1 in 2500 births ~16% of babies with CF Inspissated sticky meconium Distal small bowel obstruction May be complicated Microcolon on contrast enema may be therapeutic Contrast enema Laparotomy and washout of bowel +/- stoma

Microcolon in Meconium ileus

Hirschsprung Disease

Hirschsprung Disease 1 in 5000 births M:F 4:1 Associated with Trisomy 21 Delayed passage of meconium >48hours Abdominal distension Vomiting – may be bilious Diagnosis – rectal biopsy Aganglionosis, thickened nerve trunks, increased acetylcholinesterase

Hirschsprung Disease Aganglionosis of bowel Variable failure of neural crest cell migration Rectosigmoid – 75% Long (colonic) segment – 15% Total colonic – 5-7% Total interstinal – <5% Spastic bowel – failure to relax Requires decompression – rectal washouts Definitive surgery – pullthrough of ganglionic bowel

Anorectal malformation

Anorectal malformation 1 in 4000 births Management depends on level of ARM Primary anoplasty for low Stoma and delayed reconstruction for high Recto-urethral fistula most common in boys Recto-vestibular fistula most common in girls

Case 2 3 week old term baby Relevant points in history Relevant examination findings Differential diagnosis

Infantile Hypertrophic Pyloric Stenosis 1-4:1000, M:F 4:1 Overgrowth of pyloric muscle Gastric outlet obstruction Increasing non-bilious vomiting Metabolic derangement Hypochloremic Hypokalaemic Metabolic alkalosis Medical emergency - rehydration

Pyloric stenosis

Infantile Hypertrophic Pyloric Stenosis Diagnosis – palpable mass on ‘test feed’ USS Pyloric length >16mm Single muscle thickness >4mm Pyloromyotomy Open – supraumbilical or RUQ Laparoscopic

Inguinal hernia

Inguinal hernia Usually can reduce If truly incacerated – emergency exploration Otherwise if premature baby or younger than 4 weeks post birth – repair urgent basis

Case 3 Preterm neonate – bilious vomiting Born 27 weeks gestation Weight 1 kg 1 week post birth Relevant points in history Relevant examination findings Differential diagnosis

Necrotising Enterocolitis 90% in preterm 10% in term babies ~5% of all babies admitted to Neonatal Unit Multifactorial pathogenesis Inflammation and coagulative necrosis 20-40% require surgery Up to 50% mortality reported in those requiring surgery Worst outcome extremely low weight preterm babies

Necrotising Enterocolitis Surgery indicated for: Worsening clinical condition despite maximal supportive therapy Perforation Laparotomy Assess extent of disease - may be total gut necrosis Resection anastomosis – if appropriate Resection and stomas ‘Clip and drop’

Summary Many surgical causes of surgical neonatal vomiting Congenital obstructive and functional anomalies throughout entire gut Green vomiting is malrotation and volvulus until proven otherwise – Emergency