What Is New in HIV Infection? Journal of AAFP February 15, 2014 Volume 89, Number 4 Today is 3/26/14, and my name is Isaac Engholm, DO.

Slides:



Advertisements
Similar presentations
Gilead’s Tech Transfer Partnerships and IP in India
Advertisements

Louis Haenel, IV, DO Endocrinology. Terminology Lipodystrophy Lipoatrophy Lipohypertrophy HIV HAART (Highly Active Anti-Retroviral Therapy)
April 15 Understanding HIV Treatment and adherence. The African Eye Trust HIV Treatment Information Event By Badru Male&Elijah Amooti.
Chemistry: An Introduction to General, Organic, and Biological Chemistry, Twelfth Edition© 2015 Pearson Education, Inc Viruses HIV causes AIDS, which.
ANTIRETROVIRAL THERAPY Dr. Samuel Mwaniki (BPharm., MSc TID, UoN) University of Nairobi ISO 9001: Certified
Treatment of AIDS “Antiretroviral therapy & vaccines”
Antivirals Slackers Facts by Mike Ori. Disclaimer The information represents my understanding only so errors and omissions are probably rampant. It has.
Tuesday Case Conference. Introduction What is Tenofovir disoproxil fumarte (TDF)? How Nucleotide RTI work Nephrotoxicity of NtRTI Is TDF Nephrotoxic?
Genetic Mutations Recombinant DNA Viruses Chapter 22 Nucleic Acids and Protein Synthesis.
Vaccines and Antivirals. Clinical Use of Interferon Therefore they have been used in the treatment of cancers of various types. Therefore they have been.
1 Inhibitors of Other Viruses A. RIBAVIRIN Ribavirin (Virazole) is a nucleoside analogue in which a triazolecarboxamide moiety is substituted on place.
Combination of Drugs and Drug-Resistant Reverse Transcriptase Results in a Multiplicative Increase of Human Immunodeficiency Virus Type 1 Mutant Frequencies.
Chemistry: An Introduction to General, Organic, and Biological Chemistry, Eleventh Edition Copyright © 2012 by Pearson Education, Inc. Chapter 17 Nucleic.
Genetic Mutations A mutation alters the nucleotide sequence in DNA, which can cause a change in the amino acid structure of the corresponding protein,
Hepatitis LINK Viral Hepatitis is a group of disease that infect the liver. Three viruses - Hepatitis A, Hepatitis B and Hepatitis C are the most frequent.
Plate 87 Acquired Immune Deficiency Syndrome (AIDS)
Antiviral Chemotherapy Discovery of antiviral drugs Targets of antiviral drugs.
Anti-HIV Drugs Melissa Morgan Medicinal Chemistry November 23, 2004.
1 Introduction to ARV Therapy HAIVN Harvard Medical School AIDS Initiative in Vietnam.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display The Steps in HIV Replication Slide number 1 (1) Viral.
Clinical case 19 Lin, I-Yao (Sally). Case 19 Having been confined in the hospital for almost a month due recurrent pneumonia, Mr. XXX, 42 y/o, married,
Antiviral Drugs. Mechanism of Action Picornaviruses eg, polioviruses, cold viruses Block attachment molecule on host cell or pathogen Attachment antagonists.
The Practical Side of Nucleotide Metabolism November 29, 2001.
Antiviral Agents, chapter 39 Different living organisms.
ARV Therapy Basics in the Context of Family Planning
HIV: WHAT IS NEW? DR NYA EBAMA, M.D. LOWCOUNTRY INFECTIOUS DISEASES, PA CARETEAM PLUS, INC SEPTEMBER 18, 2015.
 HIV lives and reproduces in blood and other body fluids. We know that the following fluids can contain high levels of HIV:  Blood, Semen (cum), Pre-seminal.
Management of NRTI Resistance
Antiretroviral targets in the viral life cycle Viral Replication and Drug targets.
Antiviral drugs.
Acyclovir Lee, sang-hwi.
General, Organic, and Biological Chemistry Copyright © 2010 Pearson Education, Inc Viruses Chapter 21 Nucleic Acids and Protein Synthesis.
Viro100: Virology 3 Credit hours NUST Centre of Virology & Immunology
Virology – Antivirals 2 JU- 2 nd Year Medical Students By Dr Hamed AlZoubi – Microbiology and Immunology Department – Mutah University. MBBS (J.U.S.T)
Tenvir-Em Online Tenvir-EM tablets are used as part of a regiment of antiretroviral medications to treat HIV-1 in adults over 18 years of age. Manufactured.
Synthetic Analogues of Nucleotides
PrEP for HIV Prevention
Nucleotides, structure and function
S3 Fig Inactivity of inhibitors of reverse transcriptase and integrase
Figure 1 Inclusion criteria, exclusion criteria, and criteria for virologic failure. CDC, Centers for Disease Control and Prevention; ddC, zalcitabine;
Pharmacokinetics: HIV Drugs
PrEP as an HIV Prevention Tool in Queer Communities of Color: Barriers and Opportunities BACKGROUND Joanne Stekler, MD MPH.
Tenvir-Em Tenvir EM is a generic version of Truvada and is used as part of a regiment of antiretroviral medications to treat HIV-1 in adults over 18. Each.
AIDS Chien-Ming Li MD, Ph.D.
Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort.
ARVS AND PROGESTINS ON IMMUNE FUNCTION IN THE FEMALE GENITAL TRACT
Once Daily Etravirine versus Efavirenz in Treatment-Naive SENSE Trial
Treatment response to unboosted atazanavir in combination with tenofovir disoproxil fumarate and lamivudine in human immunodeficiency virus-1-infected.
Switching the NRTI Backbone to Tenofovir DF-Emtricitabine TOTEM
Do Patients adherent on PrEP exposed to HIV have seroconversion symptoms & falsely reactive HIV tests? Mark Roche1, Elaney Youssef1, Yvonne Gilleece¹,
Volume 132, Issue 4, Pages (April 2007)
Advances and Challenges in HIV Antiretroviral Therapy
Prevalence of drug resistance and newly recognised treatment-related substitutions in the HIV-1 reverse transcriptase and protease genes from HIV-positive.
HIV Prevention and Treatment: The Evolving Role of the Emergency Department  Kristi Stanley, MD, Meredith Lora, MD, Stephen Merjavy, MD, Jennifer Chang,
مبارزه با بیماریها دکتر آناهیتا بابک. مبارزه با بیماریها دکتر آناهیتا بابک.
Antiherpes Drugs 30 November :40 PM.
PrEP Pre-Exposure Prophylaxis
100 Partners PrEP[5] Efficacy 75% Adherence 81% 80
Drug-resistant human immunodefiency virus
Occult HIV-1 drug resistance to thymidine analogues following failure of first-line tenofovir combined with a cytosine analogue and nevirapine or efavirenz.
Damjan S. Nikolic, Vincent Piguet  Journal of Investigative Dermatology 
Antiretroviral therapy for initial human immunodeficiency virus/AIDS treatment: critical appraisal of the evidence from over 100 randomized trials and.
Replication life cycle of HIV and sites of antiretroviral drug action.
Antiviral agents.
Translated By: Owais A. Shahzada
Volume 132, Issue 1, Pages 5-6 (January 2007)
AZT = Azidothymidine (3’-azido-3’-deoxythymidine, Zidovudine)
The structure of AZT(3’-azido-2’,3’-dideoxythymidine)
Terminology HIV AIDS Acquired Human Immune Immunodeficiency Deficiency
Chapter 17 Nucleic Acids and Protein Synthesis
Presentation transcript:

What Is New in HIV Infection? Journal of AAFP February 15, 2014 Volume 89, Number 4 Today is 3/26/14, and my name is Isaac Engholm, DO

Vignette: 32 year old male 240 lbs 6’ 4” Presents to clinic for his AHM. He is accompanied by his friend.

Physical exam:

The next day… The Next Day….

O8MP3wMvqg HIV

What is PrEP? PrEP is short for Pre-Exposure Prophylaxis

Truvada Mechanism of Action Nucleoside and nucleotide reverse transcriptase inhibitor combination; emtricitabine is a cytosine analogue while tenofovir disoproxil fumarate (TDF) is an analog of adenosine 5'- monophosphate. Each drug interferes with HIV viral RNA dependent DNA polymerase resulting in inhibition of viral replication.

References: AFP Feb 15, 2014 Vol 89, Number 4 Images from fanpop.coom