Efficacy of Conjunctival Resection with Cyanoacrylate Glue Application in the Treatment of Mooren’s Ulcer Jayesh Vazirani Merle Fernandes L V Prasad Eye.

Slides:



Advertisements
Similar presentations
Survival Analysis-1 In Survival Analysis the outcome of interest is time to an event In Survival Analysis the outcome of interest is time to an event The.
Advertisements

Obesity at Diagnosis Is Associated with Inferior Outcomes in Hormone Receptor Positive Breast Cancer 1 The Impact of Body Mass Index (BMI) on the Efficacy.
Statistical Analysis and Data Interpretation What is significant for the athlete, the statistician and team doctor? important Will Hopkins
COMBINED SUTURELESS AMNIOTIC MEMBRANE TRANSPLANTATION WITH NARROW STRIP CONJUNCTIVAL AUTOGRAFT FOR PTERYGIUM Meltem Yagmur MD Nese Cetin MD T. Reha Ersoz.
Experience With Microbial Keratitis After Boston Type I Keratoprosthesis Implantation Cornea & Anterior Segment Services, L V Prasad Eye Institute, Hyderabad,
17278 Prosthetic Replacement in Steven-Johnson Syndrome Varsha Rathi Somasheila I Murthy L V Prasad Eye Institute, Hyderabad, India The authors have no.
Critical Appraisal for MRCGP Jim McMorran Coventry GP GP trainer Editor GPnotebook (
Relationship Between Donor Graft Cell Count and Visual Outcome in DSAEK Patients Authors Silvin Bakalian MD PhD, Johanna Choremis MD FRCSC, Michele Mabon.
Estimation from Samples Find a likely range of values for a population parameter (e.g. average, %) Find a likely range of values for a population parameter.
Multi-Drug Resistant Pseudomonas Keratitis Clinical Characteristics and Associated Features Jayesh Vazirani Merle Fernandes L V Prasad Eye Institute Visakhapatnam,
Stat 217 – Day 20 Comparing Two Proportions The judge asked the statistician if she promised to tell the truth, the whole truth, and nothing but the truth?
Statistics for Health Care
Analysis of Complex Survey Data
A Propensity-matched Study of Lobectomy Versus Segmentectomy for Radiologically Pure Solid Small-sized Non-small Cell Lung Cancer Terumoto Koike 1, Seijiro.
Description of fracture with endocrine therapy use in older breast cancer survivors in a population-based setting Taryn Becker 123, Geoff Anderson 123,
Inference for proportions - Comparing 2 proportions IPS chapter 8.2 © 2006 W.H. Freeman and Company.
Inference for proportions - Comparing 2 proportions IPS chapter 8.2 © 2006 W.H. Freeman and Company.
Comparing 2 proportions BPS chapter 21 © 2006 W. H. Freeman and Company These PowerPoint files were developed by Brigitte Baldi at the University of California,
Multiple Choice Questions for discussion
Dr Laura Bonnett Department of Biostatistics. UNDERSTANDING SURVIVAL ANALYSIS.
Lecture 3 Survival analysis.
FRAMING RESEARCH QUESTIONS The PICO Strategy. PICO P: Population of interest I: Intervention C: Control O: Outcome.
Outcome of therapeutic keratoplasty in fungal keratitis Sonika Gupta, MS Assistant Professor, GMCH, Chandigarh, India Author has no financial interest.
Glaucoma and Penetrating Keratoplasty : Incidence, Risk Factors, and Outcomes Sonika Gupta Consultant Ophthalmology Max Eye Care New Delhi, India Author.
Cataract Surgery After Trabeculectomy: The Effect on Trabeculectomy Function Husain R, Liang S, Foster PJ. Cataract surgery after trabeculectomy: the effect.
OFTALMOS® -SC-BRAZIL Triple Procedure for Bilateral Perforated Mooren's Ulcer G. S. Lima; P. Ferreira; A.
1 THE ROLE OF COVARIATES IN CLINICAL TRIALS ANALYSES Ralph B. D’Agostino, Sr., PhD Boston University FDA ODAC March 13, 2006.
Indications for and Outcomes of Therapeutic Penetrating Keratoplasty Sonika Gupta Consultant Ophthalmology Max Eye Care New Delhi, India Author has no.
Prospective Correlation of Symptoms and Clinical Grading in Vernal Keratoconjunctivitis Patients Srikant K Sahu, Shraddha Pawan Sureka, Sujata Das, Apurva.
How to Read Scientific Journal Articles
Clinical and Visual Outcomes of Children With Peters Anomaly Asim Ali, MD, FRCSC Uri Elbaz, MD Hermina Strungaru, MD, PhD Kamiar Mireskandari, MBChB, FRCSEd,
Severity of Herpes Zoster Ophthalmicus: Onset at Younger Than 60 Years Versus 60 Years or Older Neelofar Ghaznawi MD, Ajoy Virdi MD, Amir Dayan, Christopher.
WEILL.CORNELL.EDU Outcomes of Acute Interventions for SJS/TEN Using a Novel Grading Scale and Treatment Algorithm World Cornea Congress VII Jessica B.
Pui Yi Boey 1, Seng-Ei Ti 1, Donald TH Tan 1,2 1 Singapore Eye Research Institute, Singapore National Eye Centre 2 Dept of Ophthalmology, Yong Loo Lin.
Survival Analysis approach in evaluating the efficacy of ARV treatment in HIV patients at the Dr GM Hospital in Tshwane, GP of S. Africa Marcus Motshwane.
Mark Dacey MD, Brian Sullivan MD, and Steven Verity MD University of Texas Southwestern Medical Center and VA Medical Center, Dallas, TX None of the authors.
Topical Cyclosporine 0.05% as a Long-Term Monotherapy for Atopic Keratoconjunctivitis Jonathan H. Tzu, M.D ¹, * ; C. Asli Utine, M.D ¹,², * Michael Stern,
Outcome of cataract surgery in Scleritis patients Bhupesh Bagga Cornea & Anterior Segment Department L.V.Prasad Eye Institute, Hyderabad,India Financial.
Statistics Nik Bobrovitz BHSc, MSc PhD Student University of Oxford December 2015
Instrument design Essential concept behind the design Bandit Thinkhamrop, Ph.D.(Statistics) Department of Biostatistics and Demography Faculty of Public.
Efficacy of Topical Azithromycin & Cyclosporine A(CsA) vs CsA Alone in the Treatment of Dry Eyes Associated with Blepharitis Kenneth A. Beckman, M.D.,
Elmira Baghdasaryan1,2, M.D. Sophie X. Deng1, M.D., Ph.D.
Hongseok Yang, MD Department of Ophthalmology, Ajou University School of medicine, Suwon, Korea The author has no financial interest.
Margin of Error S-IC.4 Use data from a sample survey to estimate a population mean or proportion; develop a margin of error through the use of simulation.
Identification of localized rectal cancer (RC) patients (pts) who may NOT require preoperative (preop) chemoradiation (CRT). D. Roda 1, M. Frasson 2, E.
Article Title Resident Name, MD SVCH6/13/2016 Journal Club.
Objectives (Chapter 20) Comparing two proportions  Comparing 2 independent samples  Confidence interval for 2 proportion  Large sample method  Plus.
Evaluating the Clinical Outcomes of Sixty-Three Patients Treated with Gamma Knife as Salvage Therapy for Glioblastoma Multiforme Erik W Larson, Halloran.
ABSTRACT Purpose This retrospective review was conducted to determine if delay in the start of radiotherapy after conservative breast surgery had any detrimental.
J Clin Oncol 30: R2 윤경한 / Prof. 김시영 Huan Jin, Dongsheng Tu, Naiqing Zhao, Lois E. Shepherd, and Paul E. Goss.
Methods and Statistical analysis. A brief presentation. Markos Kashiouris, M.D.
1 R1 임준욱 Anticoagulant and Antiplatelet Therapy Use in 426 Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention and Stent Implantation.
Carolinas Medical Center, Charlotte, NC Website:
Tulsi Changulani 1,*, Jenny Bo 2, Mei-Ling Cheng 1, Andrew Tatham 1
17100 Contact lens fitting after corneal CXL
Section 9-1 Review and Preview.
The Diabetic Retinopathy Clinical Research Network
Clinical outcome after SVR: Veterans Affairs
Inferences and Conclusions from Data
Risk ratios 12/6/ : Risk Ratios 12/6/2018 Risk ratios StatPrimer.
Hippisley-Cox J, Coupland C. BMJ 2010;340:c2197
Interpreting Basic Statistics
ASPIRE CLASS 6: Interpreting Results and Writing an Abstract
LV5FU2-cisplatin followed by gemcitabine or the reverse sequence in metastatic pancreatic cancer: Preliminary results of a randomized phase III trial (FFCD.
Kaplan Meier survival curve free of CV events and Cox proportional hazards model. Comparison of ATPIII and IDF classifications Kaplan Meier survival.
Chapter 8: Estimating With Confidence
A decade after the Surgical Treatment for Ischemic Heart Failure (STICH) trial: Weaving firm clinical recommendations from lessons learned  Robert E.
JAMA Ophthalmology Journal Club Slides: Timing of Intervention in Congenital Nasolacrimal Duct Obstruction Sathiamoorthi S, Frank RD, Mohney BG. Spontaneous.
The SUV on 18F-FDG-PET/CT imaging as an independent predictor for overall survival and disease free survival after hepatectomy of Hepatocellular carcinoma(
Presentation transcript:

Efficacy of Conjunctival Resection with Cyanoacrylate Glue Application in the Treatment of Mooren’s Ulcer Jayesh Vazirani Merle Fernandes L V Prasad Eye Institute Visakhapatnam, India Jayesh Vazirani Merle Fernandes L V Prasad Eye Institute Visakhapatnam, India The authors have no financial interests to disclose

Purpose To study the efficacy of conjunctival resection with cyanoacrylate glue application in the treatment of Mooren’s ulcer

Methods Study design: Retrospective, non-randomized, interventional case series Study population: Eyes with clinically determined Mooren’s ulcer, which underwent conjunctival resection with cyanoacrylate glue application Intervention: A 3-4 mm wide strip of conjunctiva extending at least 1 clock hour beyond the margin of ulcer on either side was resected and cyanoacrylate glue was applied to the peripheral cornea. Post-operative treatment included topical steroid in all cases

Methods Outcome measures: Clinical quiescence, determined as cessation of further ulceration and infiltration, complete epithelization and no clinical evidence of inflammation. Survival rate, calculated from recurrence-free interval and total follow-up duration Statistical analysis: A Kaplan-Meier survival curve was constructed and survival probability was reported in percentages. Multivariate Cox proportional hazards model analysis was done to determine association between clinical factors and risk of recurrence

Results Sixteen eyes (eight unilateral cases and four bilateral cases) with Mooren’s ulcer underwent this procedure. Clinical quiescence was initially achieved in all eyes. Recurrence of disease was noted in 5 eyes (31.25%).

Results Case No. Age (Years) GenderEyeLaterality Baseline Visual Acuity Clock hrs of involvement 1 38MODBilateral20/ MOSBilateral20/ MODUnilateralCF MOSBilateralPL1 5 74MODBilateral20/ MOSUnilateralPL2 7 60MOSBilateral20/ MODBilateralCF MODUnilateralCF MOSUnilateral20/PL FOSUnilateral20/ MODBilateral20/ MOSBilateral20/ MODUnilateral20/ MODUnilateralCF MODUnilateral20/4005

Results Case No. Follow up (Days)Recurrence Time to recurrence (Days) Recurrence-free Survival (Days) 1 30No30 2 No No No85 5 No No Yes Yes Yes No No Yes Yes No No No630

Results Median follow-up 136 days (Range days) Mean survival probability 58.3% (standard error 14.81%) Median survival time days (Range days)

Survival Curve

Results Multivariate analysis Bilaterality - only factor significantly affecting chances of recurrence Hazards ratio (95% confidence intervals ) (p- 0.02) All recurrences were successfully treated with systemic steroid and/or immunomodulatory drugs.

Conclusions Conjunctival resection with cyanoacrylate glue application provides tectonic stability, but is of limited value in preventing recurrences of Mooren’s ulcer. Bilateral cases have a much higher risk of recurrence than unilateral cases.

Thank You L V Prasad Eye Institute Excellence  Equity  Efficiency