Nucleotide Metabolism

nucleotide nucleoside

a key molecule in purine and pyrimidine biosynthesis

purines: where does all them darn atoms come from?? fig 22-32

fig 22-33

fig 22-33

ETC. fig 22-33, sorta

inosine, built “on the ribose” to make IMP fig 22-33, still

and inosinate begat adenylate and xanthylate, and xanthylate begat guanylate… fig 22-34

regulation of the early steps of purine synthesis fig 22-35

pyrimidine biosynthesis orotate, built “off the ribose” fig 22-36

pyrimidine biosynthesis OTP then modified to CTP, etc fig 22-36

fig 22-38

1) de novo synthesis (see above) Two ways for mammals to make and/or use purines and pyrimidines 1) de novo synthesis (see above) 2) salvage pathways Ad + PRPP AMP + PP

1) de novo synthesis (see above) Two ways for mammals to make and/or use purines and pyrimidines 1) de novo synthesis (see above) 2) salvage pathways hypoxanthine + PRPP IMP + PP Lesch-Nyhan disease

1) de novo synthesis (see above) Two ways for mammals to make and/or use purines and pyrimidines 1) de novo synthesis (see above) 2) salvage pathways pyrimidine salvage is similar but not well understood in mammals…

inhibitors of glutamine amindo- transferases chemo- therapeutics fig 22-48

remember the “D” in DNA??? either or fig 22-39

what’s the difference between T and U?? fig 22-44

where the THF gets its methy... fig 22-44

more chemotherapeutics

inhibitors of dihydrofolate reductase cycle fig 22-49

catabolism of purines… xanthine oxidase fig 22-45

fig 22-45

out with gout!!! 1735

out with gout!!! xanthine oxidase too active fig 22-47

out with gout!!! xanthine oxidase inhibitor fig 22-47