Using Prostate Cryosurgery Cryocare CS ® Technology PM-3592 Rev A 08/11 This information is intended to provide general education for surgeons who have.

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Presentation transcript:

using Prostate Cryosurgery Cryocare CS ® Technology PM-3592 Rev A 08/11 This information is intended to provide general education for surgeons who have been trained to perform cryosurgery. Consult System Operator’s Manual and Component DFUs for complete instructions.

2PM-3592 Rev A 08/11 AUA Best Practice Statement Summary Babaian RJ, et al: Best Practice Statement for Cryotherapy for the Treatment of Localized Prostate Cancer. J Urology 2008; 180: Primary Treatment Patient Selection –Organ confined –Any grade –Negative metastatic evaluation BDFS (5 years) –Low risk: 65-92% –Moderate risk: 69-89% –High risk: 48-91% Negative Biopsy –87-98% Complications –Retention:1-2 weeks –Swelling:1-2 weeks –Numbness:2-4 months –Fistula:0.05% –Incontinence:1-8% –ED (at 12 months):49-93% –Sloughing (2000 data): 0-15% Salvage Treatment Patient Selection –Organ confined with positive biopsy confirming disease in prostate –PSA ≤ 10 ng/mL (Optimally ≤ 4 ng/mL) –Long PSA doubling time –No evidence of seminal vesicle invasion –Life expectancy > 10 years –Negative metastatic evaluation BDFS (Up to 5 years) –34-86% Negative Biopsy –93-94% Complications –Fistula:0-3% –Incontinence:<10% –ED:>80% –Sloughing:5-10%

3PM-3592 Rev A 08/11 Setting-40°C-20°C0°C 1.5 cm cm cm cm cm The isotherms listed above represent measurements collected using gelatin formula which approximates performance (  5mm) in soft tissue at 100% gas for 10 minutes. Markings on Handle Represent Ablative Ice Lengths

4PM-3592 Rev A 08/11 Ultrasound Basics Longitudinally oriented side fire linear array transducer displays prostate in long axis Probe is rotated clockwise and counterclockwise to see left and right of midline Longitudinal sagittal view at midline

5PM-3592 Rev A 08/11 Normal Ultrasound Anatomy Layers of Rectal Wall Balloon-mucosa interface Hypo-echoic interface of mucosa and sub-mucosa Sub-mucosa Muscularis propria Peri-rectal/ peri-prostatic fat

6PM-3592 Rev A 08/11 Prostate Cryosurgery Technique Step 1: Set up and position ultrasound probe Foley Catheter placement, fill bladder with saline Align ultrasound probe, center image, assure that plane of urethra and plane of transducer is parallel Urethra stays on centerline as you move ultrasound cradle from base to apex Measure volume (height, width, length)

7PM-3592 Rev A 08/11 Alignment of Probe Keep Urethra on Centerline

8PM-3592 Rev A 08/11 Prostate Cryosurgery Technique Step 2: CRYOGUIDE ® Planning Find the widest transverse image of the prostate and capture the image Outline the prostate staying outside capsule for high risk disease where capsular disease is suspected Outline urethra, large margin in salvage cases Outline rectal wall

9PM-3592 Rev A 08/11 CRYOGUIDE ® Planning Image Capture Capture live transrectal ultrasound image of the prostate on CryoGuide

10PM-3592 Rev A 08/11 CRYOGUIDE ® Planning Outline Prostate, Urethra and Rectal Wall

11PM-3592 Rev A 08/11 CRYOPROBE™ Placement Logic CryoProbes should be placed:  1 cm from the capsule  2 cm apart > 0.5 cm from rectal wall > 0.5 cm from urethral wall <2cm.> 0.5 cm < 1cm

12PM-3592 Rev A 08/11 CryoProbe™ and TempProbe ® placement can be verified with CryoGuide Measurement Function Key measurements can checked on screen CRYOGUIDE ® Planning Placement Measurements

13PM-3592 Rev A 08/11 Probe Placement Sequence Anterior probes anchor the gland, then work posterior to anterior to improve your access 1.CryoProbe™ devices 1 & 2 placed anterior 2.ANT, ES, APEX, DEN TempProbe ® sensors placed midline 3.CryoProbes 5 & 6 placed posterior medial 4.CryoProbes 3 & 4 placed posterior lateral 5.RNVB, LNVB TempProbes placed lateral 6.URETHRAL WARMING CATHETER placed, after cystoscopy confirms no probes have compromised the urethra

14PM-3592 Rev A 08/11 CRYOPROBE™ Freeze Sequence Activate CryoProbes anterior to posterior – Anterior (1+2)  Posterolateral (3+4)  Posteromedial (5+6) Freeze anterior CryoProbes 1 & 2 until ANT TempProbe ® reaches –20  C and ice line approaches probes 3 & 4 1 2

15PM-3592 Rev A 08/11 CRYOPROBE™ Freeze Sequence Freeze CryoProbes 3 & 4 until NVBs reach 0  C, monitor DEN TempProbe ® and rectal wall via ultrasound to ensure ice does not expand to rectal wall using sagittal (longitudinal) view! 34

16PM-3592 Rev A 08/11 Prostate Cryo: Freeze Progression Sagittal image at completion

17PM-3592 Rev A 08/11 Final Steps Active thaw until all temperatures > 0°C Remove probes Perineal pressure for hemostasis Rectal exam: confirm no ice in rectum Urethral warmer, passively thaw at least 20 min Can move warmer to Recovery Room Foley catheter or S-P tube (your choice) This information is intended to provide general education for surgeons who have been trained to perform cryosurgery. Consult System Operator’s Manual and Component DFUs for complete instructions.