Laboratory Automation & Instrumentation Power Protection Systems Case Study Celera Genomics

Celera’s Benefits Lower Operating Cost Increased Productivity Happier Investigators/Managers/Staff Higher Revenue & Investor Potential

The Lab and Operating Environment Key challenges and issues: Profitability in the laboratory and automation environments On time delivery of reportable results Overall customer satisfaction Internal and external

The Lab and Operating Environment Key issues and distracters: Instrumentation performance Human Genome race Availability and reliability Environmental conditions

The Laboratory Key issues - Environmental: Quality of power from the utility Other equipment sharing the line Centrifuges Auto loaders / robotics Pumps and heaters Bar code readers (lasers) Other PCR-DNA Sequencing Instrumentation

The Laboratory Quality of power directly from the utility: Desired waveform

The Laboratory The reality of laboratory and production power: Harmonic distortion and frequency variation waveform is typical Power Interrupt Line Sag SurgeUnder Voltage Over Voltage Line Noise Variable Frequency Switching Transient Harmonic Distortion

The Lab and Operating Environment Key issues - Environmental: Challenges for a Laboratory Productivity- Protection System (LPS) Each application must be qualified Peak loads Other instrumentation line interference (transient) Inrush currents and load (Power) factors Power connection and distribution Waveform (Volts, Hz, harmonic distortion, et al)

Franek Technologies, Inc. (FTI) The Leader in Power Protection for Medical and Scientific Instrumentation

Applications  Automation  Biotechnology  Drug discovery  DNA, human Genomics and Proteomics research  Pharmaceutical production  Clinical chemistry  Diagnostic imaging  Immunology and cytometry  Oncology  Hematology and blood banking  FDA 510(k) patient contact applications  Forensics  Scientific research  Other commercial laboratory instrumentation

Key Applications Several Billions in Protected Laboratory and Production Instrumentation  Baxter Healthcare – Over 1,800 LPS placements worldwide  Celera Genomics – 320 LPS placements in a single Lab  Mallinckrodt (Nellcor / Puritan-Bennett) – Over 200 FDA 510(k) Ventilator support – patient contact

Key Applications Several Billions in Protected Laboratory Instrumentation  Perkin Elmer / ABI, DNA & Protein Analyzers – Over 3,000 LPS placements worldwide  Datex Ohmeda, Drager and North American Drager – Over (k) LPS units for anesthesia work stations

Franek Value  Cutting Edge Technology  Engineered Qualified Application Program  Most Qualified and Experienced of all Power Protection Firms – Laboratory – Pharmaceutical – Healthcare Research – Scientific markets

LPS Economics “LPS Application Rules of Thumb”  LPS systems are very affordable  Service costs are $2,000 / Hr, or more  LPS systems have proven ROI – Instrumentation operating costs drop – Instrumentation availability is very high – Overall productivity is maximized  Instrumentation and internal customer satisfaction performance improves

FTI Case Studies Celera Genomics Corporation race with Human Genome Project ~ Several billions invested Goals  First to patent the human genome – Time Critical Race Strategy:  Develop subscription based business to genome database  Partner with major pharmaceutical clients for drug discovery Challenges:  Maintain genome sequencing focus  Keep the Rockville, MD and Foster City, CA labs operational – Sequence in PE/ABI analyzers as development schedule required – Operate nearly 350 DNA Sequencer systems simultaneously

FTI Case Studies Celera Genomics Corporation race with Human Genome Project ~ Several billions invested Laboratory Challenges and Issues  Keep the Rockville, MD and Foster City, CA labs operational – Sequence in PE/ABI analyzers as development schedule required – Operate nearly 350 DNA Sequencer systems simultaneously – Minimize laboratory infrastructure while maintaining effectiveness Strategy:  FTI Consulted as laboratory power engineering specialists  FTI’s five year partnership with PE/ABI lead to sole source orders Challenges:  LPS system design to assure DNA Sequencer operational integrity  LPS & Lab engineering modifications unique to the lab environment  Delivery and servicing of over 325 LPS units in 9 months

FTI Case Studies Celera Genomics Corporation race with Human Genome Project ~ Several billions invested Celera and PE/ABI Results  Celera claimed victory in genome discovery  Kept Rockville, MD and Foster City, CA labs operational  Established PE/ABI and FTI as key business partners  Researchers provided FTI referrals to all lab types – CDC, NIH, University, Pharmaceutical, Forensic All economic goals for Celera and PE/ABI attained  Estimated savings for Celera at over $24 Million

FTI Case Studies Celera Genomics Corporation Detailed Analysis: FTI cost savings for Celera and PE/ABI (Goals)  Prevented.10 failure / instrument / 24 hour period (minimum) – days = 127,750 operational days – Potential operational incidents = 12,775  Down time cost per incident $2,  Potential down time savings: $25,550,000 Benefit to Cost = 13:1

Engineered Laboratory Instrumentation Protection Systems /