The Aging Brain The brain changes with age The frontal cortex & hippocampus are critical to learning, memory, planning and other cognitive activities, shrink in size Changes in neuron communication Neuron damage & death Reduced blood flow to the brain Change = reduced brain function

Age-Associated Memory Impairment (AAMI) A condition characterized by mild cognitive & memory decline that occurs as part of the normal aging process It is believed to be the result of chemical changes in the brain, as well as reduced brain volume It affects close to 1 in 3 people aged 60 to 78 AAMI is a condition related to normal aging, while Alzheimer’s disease (AD) is associated with serious neuro-degeneration

Age-Associated Memory Impairment (AAMI)

What are the signs of AAMI? Difficulties in memory such as misplacing objects or forgetting names/words Trouble communicating Delayed reaction time Impaired ability to multi-task 50 years of age or older Absence of dementia

What Causes Cognitive Decline-Part1? Excess Accumulation of Toxic Amyloid-beta (Ab) Protein: “Strangles” neurons within the brain Neurons malfunction and die Impairs “communication” in the brain which causes memory and cognitive decline

What Causes Cognitive Decline-Part 2? Hippocampus Shrinkage The Hippocampus is a structure in the brain that is involved in memory, learning and spatial navigation Neuron death causes a decrease in the size of the hippocampus and overall brain size Loss of hippocampus size is associated with lower scores on memory tests

Hippocampus Volume adjusted (cm 3 ) Age (years) By the age of 25, cognitive performance has reached it’s peak and declines rapidly after the age of 40 Decline In Hippocampus Volume Accelerates Around Age 40

Poor diet (excess sugar, nutrient deficiency, processed food) Lack of physical activity Excess body weight Chronic Inflammation Social Isolation High stress Declining hormone levels Factors Associated with Cognitive Decline

Bacopa -Powerful protective effects on the brain and nervous system Citicoline -Enhances neurotransmitter balance in the brain Curcumin- Identified as one of the compounds responsible for low rates of Alzheimer’s disease in India GABA -Prevents overstimulation of the brain Ginkgo Biloba -Increases blood flow to the brain Homotaurine - Prevents shrinkage of the Hippocampus and neuron death Lion’s Mane -Calms the nervous system to improve memory and concentration Phosphatidylserine -Plays an essential role in brain cell membrane structure R-Lipoic Acid -Protects neurons from damage Brain Nutrients

Homotaurine is an amino acid discovered in marine red algae VIVImind ™ is supported by over $200 million and 15 years of scientific research, including 16 clinical studies with over 2000 individuals in Canada, USA and Europe The first nutraceutical to undergo Phase III clinical research in large, state-of-the-art, clinical trials in the field of cognition It is Clinically proven to prevent Hippocampus volume loss by 68%! Why VIVImind ™ ?

How Does VIVImind ™ Work? Homotaurine crosses the blood-brain barrier and Inhibits the Formation of Amyloid Tangles to Protect Against Neuron Death

VIVImind ™ Clinical Trial Results 1052 patients diagnosed with mild to moderate Alzheimer’s disease received a placebo or Homotaurine for 18 months 33% improvement in cognitive performance with Homotaurine 68% reduction in Hippocampus shrinkage with Homotaurine

VIVImind ™ Clinical Trial Results Results were even more effective in patients with the Apoe4 gene

Homotaurine and Alzheimer's Disease AD is a model of accelerated cerebral and cognitive aging Common cognitive domains affected Common neurological contributing factors Exacerbating effect of Aβ VIVImind ™ Reduces Aβ-induced toxicity Protects memory throughout the aging process as demonstrated in patients diagnosed with AD

How to Use VIVImind ™ Dosage adults (50 years and older) : 2 capsules(50 mg), twice daily with food Start with 1 capsule at bedtime for one week and progress to 1 capsule twice daily for an additional week before starting normal dosage Do not crush, blend or mix the capsules. Swallow whole. Duration : Efficacy is dependant on Long-term use. Use for a minimum of 6 months for beneficial effects.

VIVImind ™ Safety Safe and well tolerated upon chronic use Does not bind to plasma proteins Does not interfere with liver enzyme (CYP450) activity Does not interfere with Warfarin

VIVImind ™ Supports the Memory Centre of the Brain

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