fully implantable transmitters

product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial or venous blood, bladder, pleural), sampled at 500Hz

transmitter features (1/2) fully implantable covered with medical grade silicone completely sealed, with no battery to be replaced transmission up to 5m large and small animal models available

transmitter features (2/2) designed to be reused in multiple animals pressure leads are filled with gel that prevents blood from entering the catheter lumen ecg cables are filled with a biocompatible silicone to avoid contamination

6 types of transmitters 1 pressure 1 pressure + 1 biopotential 1 biopotential 2 biopotential 1 SNA + 1 pressure 1 SNA + 1 biopotential temperature is standard in all devices transmitters can remotely be turned on and off no need to enter the room and disturb the animals transmitters

implants are fitted with a rechargeable battery recharging is performed through patented inductive energy transfer measurement from the subject may continue while the implant is recharged there are no costs or down times due battery replacements and refurbishments chargers

rat data a few hours after implantation (courtesy Sanofi Aventis, France) blood pressure, ecg, temperature

implants for large animals can run up to 200 hours without recharging using the remote on/off feature, allow recording of 10mn every hour for more than 6 weeks long transmission range (5m) high signal resolution ability pair or group house animals

one receiver can acquire up to 12 transmitters open system with analog outputs, compatible with all data acquisition systems receivers

recharging causes an increase in tissue temperature false: continuous temperature recordings remain stable whether charging is off or on misconceptions about inductive energy transfer

repeated recharging has long term consequences false: experiments of more than 130 days, performed to verify pressure sensor stability, concurrently verified stability of all other physiological parameters recharging influences physiological parameters false: recordings show that blood pressure, heart rate, ecg morphology, and eeg power spectrum remain stable independent of charging status

sympathetic nerve activity (SNA) by telemetry a challenging application small signal amplitude (+/- 60µV) high frequency high sampling rate required

sympathetic nerve activity (SNA) by telemetry TR system provides 8kHz sampling rate integrated output with: adjustable gain adjustable integrator time constant audio output

sympathetic nerve activity (SNA) by telemetry electrodes and placement of electrodes

sympathetic nerve activity (SNA) by telemetry sample SNA recording

feature comparison Telemetry Researchcompetitor sampling frequencyup to 8000 Hz<= 500Hz pressure measurement gel filled catheteryes batteryrechargeablereturn to factory range of transmitterup to 5 mup to 1 m group housingup to 121 softwareopen platformspecific software

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