BER Long Term Measures As discussed at the last BERAC meeting with Joel Parriott (OMB) and Bill Valdez (DOE/SC) BERAC is on the hook for evaluating BER’s interim progress toward achieving its long term performance goals. A written BERAC report is due to DOE/SC and OMB no later than early 2007 when the BER PART (Performance Assessment and Rating Tool) measures will next be updated. This evaluation will, in theory, impact FY08 budget decisions. These goals were revised based on BERAC input. These revised goals (at least the Environmental Remediation goal) have been posted on the DOE/SC website and are pending OMB approval. BER has three long-term performance (and PART) goals for Life Sciences Climate Change Research Environmental Remediation Sciences Office of Science U.S. Department of Energy

BER Long Term Measures Life Sciences – By 2015, characterize the multi protein complexes (or lack thereof) involving a scientifically significant fraction of a microbe’s proteins. Develop computational models to direct the use and design of microbial communities to clean up waste, sequester carbon, or produce hydrogen. Success – Multi protein complexes involving at least 85% of a microbe’s proteins have been characterized. In addition, those proteins that are part of the 85% of a microbes proteins) thought not to be involved in forming multiprotein complexes are identified experimentally. A computational model that accurately describes the potential of a microbial community to clean up waste, sequester carbon, or produce hydrogen is developed and validated experimentally by the use or reengineering of that community based on model predictions. Minimally effective – Multi protein complexes involving at least 65% of a microbe’s proteins have been characterized. A computational model that accurately describes the potential of a microbial community to clean up waste, sequester carbon, or produce hydrogen is developed and is validated by its consistency with available data. Expert Review every 3 years will rate progress as “Excellent”, “Minimally Effective”, or “Insufficient” Office of Science U.S. Department of Energy

BER Long Term Measures Climate Change Research – By 2015, deliver improved climate data and models for policy makers to determine safe levels of greenhouse gases. By 2013, reduce differences between observed temperature & model simulations at subcontinental scales using all available, validated data. Success – Global & sub-continental temperatures and precipitation are successfully modeled, using fully coupled climate models of the Earth system, to reduce discrepancies between predictions made with models and observed data ( ) by at least half relative to the state of modeling that supported the 2001 IPCC assessment. Minimally effective – Global & sub-continental temperatures are successfully modeled, using fully coupled climate models of the Earth system, to reduce discrepancies between predictions made with models and observed data ( ) by at least half relative to the state of modeling that supported the 2001 IPCC assessment. Expert Review every 3 years will rate progress as “Excellent”, “Minimally Effective”, or “Insufficient” Office of Science U.S. Department of Energy

BER Long Term Measures Environmental Remediation – By 2015, provide sufficient scientific understanding to allow a significant fraction of DOE sites to incorporate coupled biological, chemical and physical processes for decision making for environmental remediation. Success – New science-based monitors for long-term stewardship and field tested biology based tools for cleanup of DOE sites are in use at 25% or more of DOE cleanup and long-term stewardship sites. Minimally effective – New science based monitors for long-term stewardship and filed tested biology based tools for cleanup of DOE sites are in use at 15% of the DOE cleanup and long term stewardship sites. Expert Review every 3 years will rate progress as “Excellent”, “Minimally Effective”, or “Insufficient” Office of Science U.S. Department of Energy

BER Long Term Measures Medical Applications and Measurement Sciences – Develop intelligent biomimetic electronics that can both sense and correctly stimulate the nervous system. NOTE: This is not a PART (Performance Assessment and Rating Tool goal. Office of Science U.S. Department of Energy