Improving the pig’s immune status, productivity and efficiency by enhancing gut health Rainer Rauch 4Mix International 011 866 2900 / 082 604 4569 rainerr@4mix.co.za www.4mix.co.za

Overview Anatomy and digestion Metabolic Efficiency How do we maximise Metabolic Efficiency?

Anatomy and digestion The main parts of the digestive tract 1. Stomach 2. Small Intestine 3. Cecum/Large Intestine 4. Liver (and associated organs)

Anatomy and digestion 1. Stomach Secretion of enzymes and hydrochloric acid pH = approx 2 Main enzymes = proteolytic (protein digestion) Low pH important for Partial / total eradication of microbes Hydrolysis of proteins To optimise pH-dependant protease enzyme function

Protein digestion in stomach Acid Acid dependant proteolytic enzymes

Small Intestine 2. Small Intestine Alkaline secretions results in ~ neutral pH Digestion of smaller protein chains (polypeptides) into amino acids Absorption of amino acids Bile secretion to emulsify fats, similar to detergent action (break apart globules to allow for enzyme attack) ~ neutral pH ~ neutral pH dependant protease enzymes

Cecum/ Large Intestine Fermentation chamber No enzyme secretion therefore enzyme activity due to “carry over” from small intestine or microbial enzyme production Similar in many ways to rumen Microbial fermentation = 8-16% of digestion in pig A low protein digestibility in the stomach / small intestine can lead to higher protein levels in the large intestine and an “E. coli friendly” environment E. coli has been related to oedema disease

Liver 4. Liver Metabolism of absorbed nutrients Storage organ for many minerals / certain vitamins Energy storage to control blood glucose (glycogen can be approx 8% of liver fresh weight) Bile production for effective fat digestion Main site for detoxification (e.g., mycotoxins) Synthesis of blood components Hormone manufacture e.g., IGF (Insulin-Like Growth Factor)

“Metabolic Efficiency” Gross Energy   Total energy of feed Faecal Energy Digestible Energy (DE) Energy "available" in blood Urine Energy Methane Energy Metabolisable Energy (ME) Energy available at tissue level Heat Energy (during metabolism) Net Energy (NE) Energy deposited in tissue / end product (meat, milk, eggs)

How do we maximise Metabolic Efficiency? First focus on on-farm solutions Quality of raw materials Digestibility Voluntary feed intake Mycotoxins, etc Correct and up to date formulations Genetics Feed processing Management Temperature / humidity Quality of housing / floors Stress factors (e.g. overcrowding) Well-trained staff Disease

How do we maximise Metabolic Efficiency? What can we offer?

How do we maximise Metabolic Efficiency?

Acidpro Unique Organic Acid blend researched and developed in South Africa for local conditions Unique combination of organic acids improves digestibility and feed efficiency through several mechanisms Improved pH conditions to allow for higher rate of protein digestion Reduced protein in hindgut Reduced risk of E. coli and associated endotoxin related disease

Acidpro Acidpro is more than just an ordinary organic acid blend Also contains pre- and pro-biotics to ensure that beneficial micro-organisms are established and that they proliferate Competitive exclusion of harmful micro-organisms

ClexVit ClexVit is a mycotoxin binder with a difference 3 pronged approach 1. Toxin binding 2. Toxin deactivation 3. Immune stimulation

ClexVit ClexVit is a mycotoxin binder with a difference 1. Toxin binding Different types of clay 4 different yeast cell walls (exo- and endo-toxin binding) Nanotechnology / advanced grid spacing Large surface area

ClexVit ClexVit is a mycotoxin binder with a difference 2. Toxin deactivation Enzyme forming yeasts Liver stimulating additives

ClexVit ClexVit is a mycotoxin binder with a difference 3. Immune stimulation Natural vitamin E Organic Zinc and Selenium Phosphorus improves carbohydrate and protein metabolism

ClexVit ClexVit is a mycotoxin binder with a difference 1 – 6 kg / ton depending on type of pig and severity of mycotoxin problem

What makes us unique? Up to date science to research and develop on-farm solutions Strategic symbiosis of products Honest on-farm technical support Your success is our success

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