OCT at Risø Peter E. Andersen Optics and Fluid Dynamics Department Risø National Laboratory

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT at Risø  Dermatology  Cardiology – entering into the body.  Ophthalmology – image processing.  Industrial process monitoring

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ The OCT group at OFD  Staff (scientific and technical) – Peter E. Andersen, – Thomas M. Jørgensen, – Henning E. Larsen, – Finn Pedersen, – Lars Thrane, – Andreas Tycho*.  Visiting scientists – Dr. Harold T. Yura, Aerospace, USA.  Graduate students – Frederik Nielsen.  Undergraduate students – Michael Frosz, DTU, – Laura Jensen, DTU, – David Levitz, (Rochester, USA / Lund Univ., Sweden). * recently moved to start-up company working with OCT – spun out from ODI/ODF

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ Collaborators  Collaborators (in Denmark) – Prof. Anders Bjarklev, COM, DTU, – Prof. (MD) Peter Bjerring, Marselisborg, AU, – Dr. (MD) Peter Riis Hansen, KAS Gentofte, KU, – Dr. (MD) Michael Larsen, KAS Herlev, KU.  Collaborators (internationally) – Prof. Joseph Izatt, Duke University, NC, USA, – Prof. Stefan Andersson-Engels and Katarina Svanberg, Lund Medical Laser Centre, Lund, Sweden, – Prof. Gary Tearney, Harvard, Boston, USA.

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ Building the system in the lab

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT – out of the lab

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ …and into the clinic

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT in dermatology

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT in dermatology raw image (no filtering) image after filtering

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT in dermatology normal skin skin w. burn

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT in cardiology  Coronary artery tissue (in vitro) 2 by 1 mm 2 front cover sampl e

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT in cardiology

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT – from the lab

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT – for online processing

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT – from the lab

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ Translated polymer  Polymer velocity: 0.5 mm/s – 20 depth scans, – these scans are put together in the image, – artificial lateral magnification.  Thickness: 1.13 ± 0,05 mm.  Reference scan speed must be chosen to match translation velocity.

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ Single a-scan (envelope)

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT – current activities (1)  Research – theoretical and numerical modeling of light-tissue interactions in OCT, – noise analyses of systems, – new light sources for OCT systems.  Instrumentation – novel OCT system layout to improve system SNR, – portable systems for dermatology, – endoscopy.

P. E. Andersen - 4/28/2015 Optics and Fluid Dynamics Department RISØ OCT – current activities (2)  Non-invasive medical diagnostics – dermatology; »systems for imaging melanoma/basal cell carcinoma, – ophthalmology; »diagnosing retinal diseases, – endoscopy; »cardiology (early diagnosis of vulnerable plaque).  Industrial sensors – monitoring, – quality control.