Ace Inhibitors & the Kidneys A A Jameson. Afferent Efferent.

Slides:



Advertisements
Similar presentations
Renal Physiology Overview
Advertisements

Glomerular Filtration
Efferent arteriole Afferent arteriole.
CARDIOVASCULAR PHYSIOLOGY BLOOD PRESSURE AND ITS REGULATION
Mechanisms and Management in Acute Kidney Injury Paul Stevens Kent Kidney Care Centre.
Diabetic Nephropathy.  Over 40% of new cases of end-stage renal disease (ESRD) are attributed to diabetes.  In 2001, 41,312 people with diabetes began.
David Sadava H. Craig Heller Gordon H. Orians William K. Purves David M. Hillis Biologia.blu C – Il corpo umano Excretory System and Salt and Water Balance.
The Excretory System 14 Lesson 14.1: Anatomy of the Kidney Lesson 14.2: Urine Formation, Storage, and Excretion Lesson 14.3: Diseases and Disorders of.
The Physiology of the Afferent and Efferent Arterioles
Glomerulotubular Balance-The Ability of the Tubules to Increase Reabsorption Rate in Response to Increased Tubular Load.
Chapter 25 - The Urinary System
Pharmacology DOR 101 Abdelkader Ashour, Ph.D. 9 th Lecture.
Figure 25.3b. Renal Vascular Pathway Figure 25.3c.
Major Functions of the Kidneys and the Urinary System
Na + Homeostasis. Sodium reabsorption by the nephron 1% 3% 6% 65% 25% Percentages give the proportion from filtered load reabsorbed Normally, only 1%
By Jessica Davies. Angiotensin Converting Enzyme Inhibitors Used to help control Hypertension Also they help with heart failure, preventing strokes, and.
Nephron: functional unit of the kidney
The Urinary System.
1 Endocrine Involvement: 1. ADH antidiuretic hormone (vasopressin) is a peptide hormone secreted by the pituitary gland regulates the amount of water excreted.
Drugs Acting on the Renin-Angiotensin-Aldosterone System
What is the composition of the filtrate in the capsular space?
Lecture – 2 Dr. Zahoor 1. Basic Renal Processes Glomerular filtration Tubular reabsorption Tubular secretion Urine results from these three processes.
Chapter 24 – The Urinary System $100 $200 $300 $400 $500 $100$100$100 $200 $300 $400 $500 The Glomerulus Kidney Tubules Urine “Kidneying” “Urine Town”
By Dr. Adrienne Hicks.  Cardiology  Pulmonology  Renal  Gastrointestinal  Endocrine  Reproductive  Neurology  Musculoskeletal  Psychiatry  Pediatrics.
Regulation of kidneys work. Role of kidneys in homeostasis maintenance.
All things Renal Peer Support Zoulikha Zair. RAAS.
Renal Physiology 1 Dr Derek Scott
Driving Force of Filtration n The filtration across membranes is driven by the net filtration pressure n The net filtration pressure = net hydrostatic.
REGULATION OF GFR Dr. Eman El Eter. Glomerular Filtration Rate (GFR)  Defined as: The volume of filtrate produced by both kidneys per min  Averages.
Chapter 17 Physiology of the Kidneys Dr. David Washington.
Renal Blood Flow.  Total renal blood flow: TRBF ~ 1270 ml/min ~ 20-25% of CO (5000 ml/min) ~ 90% to cortex  Total renal plasma flow: TRPF ~ 700 ml/min.
Anatomy and Physiology Part 3: Urine Formation, GFR, Control of GFR
P. 954 Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings © 2012 Pearson Education, Inc.
RENAL FUNCTIONS & GFR Dr. Eman El Eter. What are the functions of the kidney?  Regulation of water and electrolyte balance.  Regulation of body fluid.
RENAL PHYSIOLOGY DR SYED SHAHID HABIB MBBS DSDM FCPS Associate Professor Dept. of Physiology College of Medicine & KKUH.
Human Physiology Physiology of the Kidneys Chapter 13.
Control and regulation of GFR and renal blood flow
Blood Pressure Regulation- Background info ► Water will go where there are high concentrations of Salt ► Increase in water = increase in volume ► Increase.
Dr. Aya M. Serry Renal Failure Renal failure is defined as a significant loss of renal function in both kidneys to the point where less than 10.
Mechanism of urine forming. The Nephron Is the Functional Unit of the Kidney Each kidney in the human contains about 1 million nephrons, each capable.
Kidney Regulation.
Hypertension Robbins: 525 to 530, Cecil:
Regulation of Na +, K + and water Chapter 14 pages
Filtration coefficient (Kf ): Kf = GFR / net filtration pressure -GFR for both kidneys is about 125 ml/ min,the -- -net filtration pressure is 10 mm Hg,
Determinants of GFR GFR = Capillary filtration coefficient X Net filtration pressure. Increased glomerular Capillary filtration coefficient increases GFR.
Glomerular Filtration and Regulation of Glomerular Filtration Rate
Renal System: Functional unit is the Nephron. Ureter (2) Bladder (1) Urethra (1) Kidneys (2)
Value, Measurement, Autoregulation, Factors & Conditions affecting---
Regulatory functions of the kidneys Reabsorption of water – Excretion of hypertonic depends on reabsorption of water from collecting ducts Reabsorption.
Diuretics Thiazides are the preferred type of diuretic for treating hypertension, and all are equally effective in lowering blood pressure. In patients.
Glomerular Filtration and Regulation of Glomerular Filtration Rate
Presented By Dr / Said Said Elshama
Renal Physiology Series No. 3 Charles J. Foulks, M.D. 9/14/2011
Regulation of GFR Dr. Eman El Eter.
Renal physiology.
Normal glomerular autoregulation serves to maintain intraglomerular capillary hydrostatic pressure, glomerular filtration rate (GFR), and, ultimately,
Regulation of GFR Dr. Eman El Eter.
YU Yanqin, PhD Zhejiang University, School of Medicine
New Insights Into the Pathophysiology of Renovascular Hypertension
From secondary to primary prevention of progressive renal disease: The case for screening for albuminuria  Paul E. De Jong, Barry M. Brenner  Kidney International 
filtration rate (GFR), and sodium (Na+) excretion
Kidney.
Chapter 26 Urinary System
Glomerular Filtration and Regulation of Glomerular Filtration Rate
Chapter 26 The Urinary System Part B.
Kidney.
Regulation of tubular reabsorption
Regulation of Tubular Reabsorption
Presentation transcript:

Ace Inhibitors & the Kidneys A A Jameson

Afferent Efferent

CHF ! RENIN RENIN Or Diuretic Drop in perfusion and GFR

CHF ! Angiotensin II Vasocontriction Increases Glomerular Pressure and Filtration

CHF ! Angiotensin II CHF ! ACE Inh.  C.O. Ace Inhibitors Can reverse this compensator y mechanism and shut down urine output You hope increased C.O. will restore flow

Early Diabetes Characterized by Hyperfiltration Normal A II tone

CHF ! Angiotensin II Diabetes post ACE Angiotensin constriction removed Hyperfiltration and damage reduced

CHF ! Angiotensin II CHF w/ renal function preserved by A II CHF w/ renal function preserved by A II Secondary benefit from Prostaglandin dilation on the supply side

CHF ! Angiotensin II PG

NSAID + ACE Drip The combination removes both the Prostaglandin dilation and the Angiotensin Efferent constriction

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.