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Presentation transcript:

The Well- Connected Cell Text and image sources are included using the notes function of this file

Classes of cell-cell junctions typefunction tight junctionssealing anchoring junctionsstructural interconnection communicating junctions communication

Tight (Occluding) Junctions ZO-1 ZO-3 DNA Claudins Occludins JAMs Organizers Informants Sealers ß-catenin PTEN

Tight Junctions seal dense tracer

Tight Junction interactome

Anchoring junctions strengthen

I. Belt (Adherens) Junctions in cardiac muscle Cadherin CAMs

Belt Junctions back up tight junctions

The Adherens Junction Interactome The Adherens Junction interactome

Forging links GFP::actin

II. Desmosomal Junctions Cytokeratin Desmosomes (Plakoglobins anchor MFs)

A day in the life of an epithelium Desmocollin -GFP Imaged over a 24 hour period

III. Hemidesmosomes anchor IMF to ECM via integrin Heterodimers (18 alpha x 8 beta) ECM RGD (Arg-Gly-Asp)

Loss of hemidesmosomal connections creates blistering diseases

IV. Focal Adhesion sites (FAds) link microfilaments to ECM

FAd interactome

Focal Adhesion Kinase (FAK) /VASp

FAds anchor stress fibers Actin-GFP and Vinculin

GFP::VASp localizes at FAds

Special Delivery? Microtubules target FAds GFP::tubulin and Ds-Red::zyxin FAds) GFP::CLIP-170 (+TIP) and Ds-Red::zyxin FAds)

Communicating Junctions GFP-Connexin-43 localizes at cell-cell contact points

Connexin hexamers form gap junctions fields 2nm

Gap junction fields Tightly- packed gap junctions

Gap junctions permit low MW molecules (<1kDa) to move between cells scrape

Gap junction interactome

AFM of gap junction field reveals the 6- fold symmetry of the connexion channel +Ca ++ -Ca ++ And a role for calcium in conductance regulation

Calcium Wave

Electrical coupling in engineered heart muscle tissue

Plasmodesmata The symplast refers to the linked protoplasmic network in plants

Plant cell lineages are linked in distinct symplastic routes

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