Principles of Immunology Overview of Innate Immunity 1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey
Review(T/F) Jenner was the first to introduce variolation Innate immune responses are specific T cells are either T-helper or T-cytotoxic cells Immunological memory results in an amanestic response All antigens are immunogens
Innate Immunity Nonspecific host defenses that exist prior to exposure to an antigen. Involves the following components: Anatomic Physiologic Phagocytic Inflammatory
Word List Antibody Antigen Complement Endocytosis Humoral Macrophage Monocyte Neutrophil
Barriers to Antigenic Insult Anatomic Skin Mucous membranes Physiologic Temperature pH Chemical mediators
Cellular and Inflammatory Components of Innate Immunity Phagocytic cells Inflammatory Vasodilation Capillary permeability
Anatomic Barriers Skin Epidermis Dermal layer Sebaceous glands Normal flora
Anatomic Barriers Mucous membranes Physical barrier Secretions Cilia Normal flora
Physiologic Barriers Temperature pH Varies by species Febrile response Endogenous pyrogens pH Skin GI tract
Physiologic Mediators of Innate Immunity Chemical mediators Enzymes Interferon Complement Three pathways Classical MB Lectin Alternative
Physiologic Mediators of Innate Immunity(cont’d) Chemical mediators Collectins Toll-like receptors Acute phase proteins
Cellular Component of Innate Immunity Phagocytic cells Monocytes Neutrophils Macrophages Non-Phagocytic cells Natural killer cells
Inflammatory Response Hallmarks of inflammation Rubor Tumor Calor Dolor Primary cell Activated macrophage
Inflammatory Response(cont’d) Biological effects Vasodilation Capillary permeability Phagocyte migration
Inflammatory Response(cont’d) Chemical mediators of inflammation Histamine Kinin system Fibrin system