Some stuff about cortical network modelling what I done Richard Tomsett 1,2, Miles Whittington 3, Mark Cunningham 4, Marcus Kaiser 2,4 1.Institute of Ageing.

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Presentation transcript:

Some stuff about cortical network modelling what I done Richard Tomsett 1,2, Miles Whittington 3, Mark Cunningham 4, Marcus Kaiser 2,4 1.Institute of Ageing and Health, Newcastle University 2. School of Computing Science, Newcastle University 3. Hull York Medical School, University of York 4. Institute of Neuroscience, Newcastle University OSB Hackathon, UCL, 6 th November 2013

Matthew Ainsworth

OSB Hackathon, UCL, 6 th November 2013 Matthew Ainsworth

OSB Hackathon, UCL, 6 th November 2013

NB: wrong dimensions in Bush & Sejnowski 1993

OSB Hackathon, UCL, 6 th November 2013 Thanks to: -Anna Simon -Mark Cunningham -Marcus Kaiser -BBSRC, Wellcome Trust

OSB Hackathon, UCL, 6 th November 2013

LFP simulation 100um – 1000um

OSB Hackathon, UCL, 6 th November 2013 LFP simulation

OSB Hackathon, UCL, 6 th November 2013 LFP simulation 100um – 1000um

OSB Hackathon, UCL, 6 th November 2013 LFP simulation Edge Half-way to gamma generating region

OSB Hackathon, UCL, 6 th November 2013 LFP simulation 100um – 1000um

OSB Hackathon, UCL, 6 th November 2013 LFP simulation Top Middle Bottom

OSB Hackathon, UCL, 6 th November 2013 Kawaguchi & Kondo, 2002

Basket cell Bitufted cell Axo-axonic cell Pyramidal cell GABA A +GABA B Neurogliaform cell “Regular spiking non pyramidal cell” Slide courtesy of Anna Simon

Basket cell Other interneurons Pyramidal cell GABA A

OSB Hackathon, UCL, 6 th November % basket cell reduction in central 2mm section, replaced by non-basket interneurons (regular spiking)

OSB Hackathon, UCL, 6 th November 2013 Thanks to: - Matt Ainsworth (York) - Anna Simon (Newcastle) - Mark Cunningham (Newcastle) - Miles Whittington (York) - Marcus Kaiser (Newcastle) -BBSRC, EPSRC, Wellcome Trust