1 LAMININE (YTF, OPTI-9, PTSE) Steven P. Petrosino, Ph.D., FACAM, MARHP Gold Director LifePharm, Inc.

2 Let your food be your medicine, and your medicine be your food ― Hippocrates (c. 460 BC – c. 370 BC)

3 FIBROBLAST GROWTH FACTOR

4 FGFs are a group of GFs that act on the fibroblast within the body. Fibroblast are basic building blocks of fibrous tissue, including the brain, nervous system, eye, blood vessels, heart, stomach, skin, liver, kidney, muscle and bone. In fact, most cells within these organs possess receptors for FGF and therefore are susceptible to its biological effect. There are 22 isoforms (types) of FGF. In adults, FGFs are homeostatic factors and function in tissue repair and response to injury. Different GFs have different jobs to do. Generally, all of them work at the cellular level to: Repair damaged cells Enhance cellular proliferation Maintain optimum function of the target organ Rejuvenate aging tissues

5 Body parts that respond to biological stimulation of FGF include: Nervous system (brain, central nervous system) Cardiovascular system (heart, circulatory system) Skin (dermis, epidermis, and underlying circulatory system) Eye (cornea and retina) Gastro-intestinal system (stomach and intestine) Hair (hair follicle and the sub-scalp circulatory system) Musculo-skeletal system (muscle, bone, cartilage) Liver and Kidney (target organ cells)

6 FIBROBLAST GROWTH FACTOR (FGF)  In normal tissue, basic fibroblast growth factor is present in basement membranes (lining of the skin, organs and extracellular matrix of blood vessels)

7 FIBROBLAST GROWTH FACTOR (FGF)  It has been hypothesized that, during both wound healing of normal tissues FGF is activated, and mediates the formation of new blood vessels, a process known as angiogeness.  FGF has been shown in preliminary animal studies to protect the heart from injury associated with a heart attack, reducing tissue death and promoting improved function after reperfusion.  Recent evidence has shown that low levels of FGF2 play a key role in the incidence of excessive anxiety.

8 Laminine supplies critical Fibroblast Growth Factor (FGF) which supports stem cells by assisting in differentiation of undifferentiated stem cells. Earliest research on FGF dates from the 1980s. FGF is present within the white of an incubated, fertilized hen’s egg, and is nearing it’s peak on the 9 th to 11 th day Fibroblasts (Fibro + Blast) are essential cells which build the extracellular matrix of the body and stimulate the natural production of collagen, the structural framework of our bodies. Collagen also lines the working surfaces of our articular joints. Fibroblast Growth Factor (FGF)

9 Recent research has shown that Low levels of FGF are associated with excessive anxiety and anxiety attacks. FGF is critical to the support of human embryonic stem cells FGF is a critical component of the wound healing, tissue regeneration and repair process. FGF concentrates itself at the site of tissue and organ damage (i.e. heart attack and stroke) Altman and his coworkers, writing in the Journal of Science in 1962, found that milti-potent neural stem cells are formed in the brain in response to damage or abnormalities. Fibroblast Growth Factor (FGF) Stem Cell Fibroblasts

10 Readily available in human placenta, FGF diminishes as we age. FGF plays a critical role in angiogenesis (development of new blood vessels) which is important in bodybuilding and healing of injuries to tissues and organs. BEFORE AFTER

11 FGF and tissue re-growth   Regeneration of amputated limb-buds in early rat embryos. Deuchar EM. J. Embryol. exp. Morph. Vol. 35, 2, pp , 1976  “…at stages prior to organ formation all early vertebrate embryos…are capable of replacing very large areas of tissue if these are removed, because their cells at this stage are very versatile and can adapt …”

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