Chapter 11 Disorders of White Blood Cells and Lymphoid Tissues Essentials of Pathophysiology Chapter 11 Disorders of White Blood Cells and Lymphoid Tissues

PRE LECTURE QUIZ (TRUE/FALSE) White blood cells (granulocytes, monocytes, and lymphocytes) are formed in the bone marrow. The life span of white blood cells is relatively long, so constant renewal is not necessary to maintain normal blood levels. In neutropenia, all of the cell lines are affected, resulting in anemia, thrombocytopenia, and agranulocytosis. Infectious mononucleosis is a self-limiting disorder caused by the Epstein-Barr virus (EBV). Non-Hodgkin is a form of lymphoma that is associated with the presence of an abnormal cell called a Reed-Sternberg cell.

PRE LECTURE QUIZ Acute Cell Leukemia Philadelphia (Ph) thrombocyte/ platelet   Clinical manifestations of acute leukemia include petechiae, ecchymosis, gingival bleeding, and epistaxis, as a result of a decreased ________________________________ level. More children are stricken with ____________________ than with any other form of cancer, and it is the leading cause of death in children between the ages of 1 and 14 years. The ________________ leukemias have a sudden and stormy onset with symptoms of depressed bone marrow function (anemia, fatigue, bleeding, and infections). The leukemias are classified according to their predominant ________________________ type. Chronic myelogenous leukemia is associated with the presence of the _________________________ chromosome, arising from a reciprocal translocation between the long arm of chromosome 22 and the long arm of chromosome 9.

Developmental Stages of Blood Cells

White Blood Cells

White Blood Cells or Leukocytes Granulocytes Neutrophils: primary pathogen-fighting cells Eosinophils: help control allergic responses; fight parasites Basophils: release heparin, histamine, and other inflammatory mediators

White Blood Cells or Leukocytes (cont.) Lymphocytes B cells: create antibodies T cells: control immune response; cell-mediated immunity Natural killer cells: kill antigenic cells Monocytes/macrophages: antigen-presenting cells; create inflammatory mediators

Question Which type of leukocyte works the hardest when you receive a vaccination? Eosinophil Basophil B-lymphocyte Neutrophil

Answer B-lymphocyte A vaccination introduces antigens, causing your body to create antibodies to fight the antigens. B-lymphocytes create those antibodies. Eosinophils and basophils are part of the allergic/immune response; neutrophils work to fight infections.

Cell differentiation Author: Please add title.

MYELOID TREE common myeloid stem cells committed precursor cells platelets erythrocytes monocytes and granular leukocytes

LYMPHOID TREE common lymphoid stem cells committed precursor cells T B lymphocytes lymphocytes natural killer cells

Multipotent stem cells common common lymphoid myeloid stem stem cells cells committed committed precursor precursor cells cells T B platelets erythrocytes lymphocytes lymphocytes monocytes natural and killer granular cells leukocytes

Question Which type of leukocyte is created in the bone marrow (myeloid)? Eosinophil Basophil Neutrophil All of the above

Answer All of the above Granular leukocytes are created in the bone marrow; eosinophils, basophils, and neutrophils are all granular leukocytes.

His doctor has prescribed several drugs: Scenario: A man has cancer and is being given radiation therapy… His doctor has prescribed several drugs: Question: Why have the following drugs been prescribed? Erythropoietin Granulocyte-monocyte colony-stimulating factor Thrombopoietin

White Blood Cell Count White blood cell counts vary between species The denser the population, the more neutrophils The more sexual partners, the more eosinophils Question: What can you infer about diseases in these populations?

White Blood Cell Deficiencies Leukopenia Neutropenia (agranulocytosis) Aplastic anemia Infectious mononucleosis HIV

Question Patients with HIV are immunocompromised. Which type of leukocyte is the best indicator of immune function? Neutrophil Eosinophil T-lymphocyte Monocyte

Answer T-lymphocyte Because T-lymphocytes direct the immune response, they are used to evaluate immune function. Patients with HIV are usually treated pharmacologically when their T-cell counts drop below 350 cells/mm3; they are considered to have AIDS when their T-cell counts drops to 200 cells/mm3.

Author: Please add title.

Acute myeloid leukemia (AML) Leukemias Malignant neoplasms of hematopoietic stem cells In bone marrow Create abnormal white blood cells: 2 types of leukemia Lymphocytic Myelogenous Acute myeloid leukemia (AML)

AML Myeloid Blasts Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Auer rods are clumps of granular material that form elongated needles seen in the cytoplasm of leukemic blasts.

Myelocytic Leukemias Mutation of myeloid cell line Overproduction of abnormal monocytes or granulocytes Production of other cell types decreases Multipotent stem cells common neoplastic mutation lymphoid in myeloid myeloid stem cells stem cells stem cells neoplastic committed precursor cells abnormal monocytes or granular leukocytes

Lymphocytic Leukemias Mutation of lymphoid cell line Overproduction of abnormal immune cells Production of other cell types decreases Multipotent stem cells common mutation in neoplastic myeloid stem lymphoid lymphoid cells stem cells stem cells neoplastic committed precursor cells neoplastic B or T lymphocytes or natural abnormal B or T lymphocytes or Natural killer cells Killer cells

Leukemias What is the difference between: Acute vs. chronic Lymphocytic vs. myelogenous

AML GENE TRANSLOCATION Author: Please add title.

Leukemias Affect Bone Marrow Activity Question: How would this cause: Bone pain and risk of fractures? Anemia? Thrombocytopenia? Immune suppression?

Question What signs and symptoms will result when…? Abnormal WBCs are produced and they… Release inflammatory mediators Infiltrate peripheral lymphoid organs Increase blood viscosity Create waste products

A child develops night sweats and nosebleeds… Scenario: A child develops night sweats and nosebleeds… He appears pale, weak, and fatigued Cervical lymph nodes are enlarged Blast count is elevated After chemotherapy, he develops hyperkalemia. Question: Why did this happen?

Answer When there is a breakdown or destruction of cells, the electrolyte potassium moves from inside of the cell to outside of the cell wall.  This shift of potassium outside of the cells causes hyperkalemia.

Lymphoma vs. Leukemia or Dyscrasias They travel to the lymphoid organs to mature and develop WBCs are formed and differentiate in the bone marrow Lymph node Neoplasms arising here cause leukemias or plasma cell dyscrasias Neoplasms arising here are lymphomas

Lymphomas Hodgkin lymphoma Malignant B cells invade lymphoid organs Non-Hodgkin lymphoma B cell T cell

Myeloma Abnormal B cells Can form tumors Produce abnormal antibodies dyscrasias - a malfunction or abnormal condition, esp. an imbalance of the constituents of the blood. Abnormal B cells Can form tumors Produce abnormal antibodies Immune depression Proteins increase blood viscosity Infiltrate organs Proliferation of osteoclasts Break down bone

Question True or False: Hodgkin lymphoma has a better prognosis than non-Hodgkin lymphoma.

Answer True Non-Hodgkin lymphoma originates from malignancies in both T- and B-lymphocytes, where Hodgkin malignancies originate in B-cells (a specific type called the Reed-Sternberg cell). Therefore, more immune function is lost in non-Hodgkin lymphoma, and the prognosis is not as good.