Morphology of RCB in health and disease Hematology CLS 531 Prepared by: Hajar AlQadeeb.

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Presentation transcript:

Morphology of RCB in health and disease Hematology CLS 531 Prepared by: Hajar AlQadeeb

Objectives Discuss the procedure for proper red blood cell examination with respect to: – objective(s) used – area examined Discuss various aspects of red cell morphology related to cell size Discuss various aspects of red cell morphology related to cell color. Discuss various aspects of red cell morphology related to cell shape.

Normal RBC Size: Normocyte Colour: Normochromic

Rouleax formation (thick part of film)

Variation in size Anisocytosis

Variation in shape Poikilocytosis

Variation in size Macrocyte Megaloplastic anemia, liver disease

Variation in size Microcyte Iron deficiency anemia, Thalasimia,and Sidroblastic anemia

Variation in shape Elleptocytosis: Elleptocyte= Rod-like

Variation in shape Schistocyte= RBC fragment

2 1 1)Sickled cell Variation in shape variation in colour 2)Target cell Sickle cell anemia

Variation in shape Burr cells (Echinocytes) Found in Uremia and Pyruvate kinase deficiency.

Variation in shape Poikilocyte = Pear or tear shaped

Variation in size:Microcyte Variation in colour: A)Target cell B)Hypochrmatic Iron deficiency anemia

Variation in content Nucleated RBC= late normoblast

Variation in content Basophilic stippling or RBC stippling

Variation in content Reticulocyte = immature RBC

Reticulocyte

Variation in content Heinz body Found in G6PD deficiency anemia.

Cont.

Variation in content Pappenhiemer bodies

Variation in content Howel Jolly bodies

The End