A Patient’s Guide to BOTOX® Cosmetic Treatment Hooman Soltanian, MD, FACS 29017 Cedar Road Lyndhurst, OH 44124 440.461.7999

The BOTOX® Cosmetic Commercials Click on image to view

BOTOX® Cosmetic Overview History of BOTOX® Cosmetic How lines and wrinkles can form between the brows How BOTOX® Cosmetic works What to expect from a BOTOX® Cosmetic procedure What you should know before a BOTOX® Cosmetic procedure

BOTOX® Cosmetic Overview Continued Results with no downtime Results typically seen in days and can last up to 4 months Results people notice Results that look natural BOTOX® Cosmetic safety BOTOX® Cosmetic summary

One-of-a-Kind Treatment BOTOX® Cosmetic One-of-a-Kind Treatment The only FDA-approved prescription treatment For the temporary improvement in the appearance of moderate to severe frown lines between the brows in patients 18 to 65 years of age Over 2 million people treated since FDA approval in 20021 After this presentation, we, as patient and physician, can decide if BOTOX® Cosmetic is right for you. 1ASAPS news releases page. 2003 ASAPS statistics — 8.3 million procedures: American Society for Aesthetic Plastic Surgery reports 20 percent increase. Available at: http://surgery.org/press/news-release.php?iid=325. Accessed July 7, 2004.

How Lines and Wrinkles Can Form Between the Brows Movement of brow muscles causes the skin to crease Skin becomes less elastic over time; repeated frowning creates lines and wrinkles between the brows (the clinical term is glabellar lines) Corrugator Muscles Procerus Muscle

Patient Testimonial “I realized my frown lines had grown strong enough that even in my relaxed state, they were fairly pronounced.”

How BOTOX® Cosmetic Works BOTOX® Cosmetic is a purified protein that smoothes the muscles by blocking nerve impulses With a few tiny injections, BOTOX® Cosmetic blocks the release of acetylcholine, the chemical that causes muscles to contract With less movement, the skin surface gradually smoothes out, and the lines begin to fade

What to Expect From a BOTOX® Cosmetic Procedure Simple 10-minute procedure consists of a few tiny injections Results typically seen in days and may continue to improve during the first week after treatment (results may vary) No anesthesia is required You may be advised to numb the area with a cold pack or anesthetic cream prior to injecting Minimal and brief discomfort Most patients compared the sensation to a bug bite There may be slight temporary bruising at the injection site This can be easily covered up with makeup Advance to Video Advance to Next Slide

BOTOX® Cosmetic Injection Video Click on image to view

What You Should Know Before a BOTOX® Cosmetic Procedure To ensure the best treatment outcome: Your physician should inject 20 units in the glabellar region between the brows Units to BOTOX® Cosmetic is like millimeters to blood pressure Ensure you receive the proper dosage for best results! Dosage amount is not based on the number of syringes used! Ask your doctor exactly how many units you are receiving

Results… With No Downtime After the procedure, you can resume normal activity Before After Unretouched clinical photos taken at maximum frown before and 30 days after BOTOX® Cosmetic treatment. Individual results may vary.

Results… Seen in Days and Can Last Up to 4 Months Before After Unretouched clinical photos taken at maximum frown before and 30 days after BOTOX® Cosmetic treatment You’ll typically see improvement within days that may continue to improve during the first week after treatment With proper unit dosing, the effects of BOTOX® Cosmetic can last up to 4 months* In clinical studies, the majority of people (82.5%) reported an improvement in the lines between their brows after a week (n = 405) *Individual results may vary

Patient Testimonial “I’ve had the BOTOX® Cosmetic procedure 3 times, and I’m going to incorporate it into my routine as just maintaining myself…every 3 to 4 months.”

The Results Speak for Themselves! BOTOX® Is the Most Popular Nonsurgical, Physician-Administered Cosmetic Treatment Before After Unretouched clinical photos taken at maximum frown before and 30 days after BOTOX® Cosmetic treatment The most popular physician-administered cosmetic procedure The American Society of Aesthetic Plastic Surgery ranked BOTOX® Cosmetic as the most popular of all physician-administered cosmetic procedures in 2002 and 2003 (surgical and nonsurgical combined) 90% of men and women surveyed rated the improvement in their appearance of brow frown lines as moderate to better after 1 month Individual results may vary

Patient Testimonial “I see a difference, but more importantly, friends and family have seen a lot of difference.”

Results… That Look Natural With BOTOX® Cosmetic, you will not look “like you’ve had work done” You can still frown, smile, or look surprised without the wrinkles and creases between your brows “I saw that I was able to smile and look natural and warm, and I’m happy with that.”

BOTOX® Cosmetic—Safety Contraindicated in the presence of infection at the proposed injection site(s) and in individuals with known hypersensitivity to any ingredient in the formulation Patients with neurological disorders such as ALS, Myasthenia Gravis, or Lambert-Eaton syndrome may be at increased risk of serious systemic side effects Serious and/or immediate allergic responses have been rarely reported These reactions include severe shock, hives, fluid build-up in soft tissues, and shortness of breath If such a reactions occurs, further BOTOX® Cosmetic injection should be discontinued and appropriate medical therapy immediately started

BOTOX® Cosmetic—Safety Continued The most common side effects include headache, respiratory infection, flu syndrome, temporary eyelid droop, and nausea Less frequently occurring (< 3%) adverse reactions included pain in the face, redness at the injection site, and muscle weakness These events are thought to be associated with the injection and occurred within the first week Full prescribing information has been provided to your physician

BOTOX® Cosmetic—Summary BOTOX® Cosmetic is a simple, 10-minute procedure and can reduce the appearance of frown lines between the brows within days No recovery time is required Noticeable improvement typically within days, and lasting effect up to 4 months (results may vary) The most common side effects are headache, respiratory infection, flu syndrome, temporary eyelid droop, and nausea Full prescribing information has been provided to your physician

Questions to Ask Your Doctor Am I a good candidate for BOTOX® Cosmetic treatment? What is your experience in using BOTOX® Cosmetic for frown lines between the brows? What kind of results can I expect based on my personal profile? How many units of BOTOX® will I be receiving on my frown lines between the brows?