Molecular Biology C SSheng Zhao ( 赵晟 ), Biochemistry and Molecular Department of Medical school in Southeast University CCouse QQ Club: ( 分子生物学 C ) WWeb: E or QQQ /MSN/Skype/gChat: MMobile: or Conception, theory, research, and application ——Logic and LIY (Learn It Yourself)

Section 1 : “Sexual” plant ——Plant genes contribute to a sexually transmitted disease. (Horizontal gene transfer) Section 2 : “Natural in vivo system for tissue repair” ——Adult mesenchymal stem cells (Stem cell research) Case 6 : DNAs of our lives ——The role of pharmacogenomics in modern medicine (Clinic medicine research) Chapter 6: Water and Fish (Translational biology and molecular medicine)

Role of pharmacogenomics in drug discovery and development ID : 黄梦琪 徐琳 徐琳 郭子维 郭子维 潘晓雨 潘晓雨

Lecture Overview Pharmacogenomics basics Pharmacogenomics basics Pharmacogenomics applications in treating disease Pharmacogenomics applications in treating disease Ethical, legal, social, and regulatory issuesEthical, legal, social, and regulatory issuesEthical, legal, social, and regulatory issuesEthical, legal, social, and regulatory issues

Pharmagogenomics basics

disease age gender renal and liver ethnicity nutritional status the way a person responds to a drug is a complex trait that is influenced by many different genes. DNA

Pharmagogenomics basics enzymes transporters receptors drug targets DNA—the way a person responds to a drug is a complex trait that is influenced by many different genes. 30% 70%

What is pharmacogenomics? ~is the technology that analyses how genetic makeup affects an individual's response to drugs~is the technology that analyses how genetic makeup affects an individual's response to drugs —— Wikipedia ~is the study of how genes affect a person’s response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person’s genetic makeup~is the study of how genes affect a person’s response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person’s genetic makeup —— ACCP

Are we ready for personalized medicine?

10 DNAs of our lives pharmacogenomics in modern medicine ——The role of

11 Background Pharmacogenomics ？ What is The New England Journal of Medicine, 2003 Pharmacogenomics is an emerging discipline that will be essential for implementing personalized medicine.

文字动画 Methods phenotype&genotype medicine response profiles linkage&association analysis Expression polymorphism analysis SNPs Chip/Sequencing

13 Aim Pharmacogenomics can provide molecular diagnostic methods that improve drug therapy.

14 Genetic Polymorphism  Drug Disposition drug metabolism drug transporters  Drug Targets Work or not  Side Effects What else

Ethical, social and legal issues in pharmacogenomics ID: 徐琳

DESIGNER DRUGS AND ECONOMIC EQUITY PREMEDICATION GENETIC TESTING DUTIES TO WARN THE ETHICS OF 'PHARMING'

DESIGNER DRUGS AND ECONOMIC EQUITY Drugs design industry government

PREMEDICATION GENETIC TESTING GOOD OR BAD?

DUTIES TO WARN Pharmacogenomics may lead to legal requirements for direct disclosure to the public about genetic risks from drugs. Genetic testing may remove some of the uncertainties and make the information more comprehensible to the public. Duties to warn of possible adverse reactions and the need for premedication testing may need to be extended to include warning the general public, especially if there is direct advertising to potential patients.

THE ETHICS OF 'PHARMING' Using genetically altered animals to produce human drugs ('pharming') raises special ethical issues beyond those usually associated with humane care of animals.