HOW DOES CYANIDE AFFECT RESPIRATION

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http://usmle.biochemistryformedics.com/wp-content/uploads/ETC.png HOW DOES CYANIDE AFFECT RESPIRATION? During WWII prisoners in Nazi concentration camps were killed in gas chambers using Cyclon B. This gas contained CYANIDE, an noncompetitive inhibitor of the enzyme cytochrome c oxidase. Cyanide binds to the iron cofactor in this complex and prevents the passing of electrons from cytochrome c oxidase to oxygen at the end of the electron transport chain. EXPLAIN WHY THIS WOULD KILL SOMEONE. PROVIDE EVIDENCE TO SUPPORT YOUR CLAIM.

http://usmle.biochemistryformedics.com/wp-content/uploads/ETC.png HOW DOES CYANIDE AFFECT RESPIRATION? During WWII prisoners in Nazi concentration camps were killed in gas chambers using Cyclon B. This gas contained CYANIDE, an noncompetitive inhibitor of the enzyme cytochrome c oxidase. Cyanide binds to the iron cofactor in this complex and prevents the passing of electrons from cytochrome c oxidase to oxygen at the end of the electron transport chain. EXPLAIN WHY THIS WOULD KILL SOMEONE. PROVIDE EVIDENCE TO SUPPORT YOUR CLAIM.

http://usmle.biochemistryformedics.com/wp-content/uploads/ETC.png HOW DOES CYANIDE AFFECT RESPIRATION? During WWII prisoners in Nazi concentration camps were killed in gas chambers using Cyclon B. This gas contained CYANIDE, an noncompetitive inhibitor of the enzyme cytochrome c oxidase. Cyanide binds to the iron cofactor in this complex and prevents the passing of electrons from cytochrome c oxidase to oxygen at the end of the electron transport chain. EXPLAIN WHY THIS WOULD KILL SOMEONE. PROVIDE EVIDENCE TO SUPPORT YOUR CLAIM.

http://usmle.biochemistryformedics.com/wp-content/uploads/ETC.png HOW DOES CYANIDE AFFECT RESPIRATION? During WWII prisoners in Nazi concentration camps were killed in gas chambers using Cyclon B. This gas contained CYANIDE, an noncompetitive inhibitor of the enzyme cytochrome c oxidase. Cyanide binds to the iron cofactor in this complex and prevents the passing of electrons from cytochrome c oxidase to oxygen at the end of the electron transport chain. EXPLAIN WHY THIS WOULD KILL SOMEONE. PROVIDE EVIDENCE TO SUPPORT YOUR CLAIM.

http://usmle.biochemistryformedics.com/wp-content/uploads/ETC.png HOW DOES CYANIDE AFFECT RESPIRATION? Cyanide is an inhibitor of the enzyme cytochrome c oxidase (also known as aa3) in the fourth complex in the membrane of the mitochondria of cells. It attaches to the iron within this protein. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted, meaning that the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Antidotes to cyanide poisoning include hydroxocobalamin and sodium nitrite which release the cyanide from the cytochrome system, and rhodanase, which is an enzyme occurring naturally in mammals that combines serum cyanide with thiosulfate, producing comparatively harmless thiocyanate.