Your first mentored grant proposal: The National Institutes of Health F and K proposals Alison K. Hall, Ph.D. Case School of Medicine Office of Graduate Education

Committee on National Needs for Biomedical and Behavioral Scientists, a unit of the National Research Council, the operating arm of the National Academy of Sciences. Estimates that there are some 52,000 postdocs in the country (2001) 3/4 in life sciences, half from foreign countries

Postdoctoral trainess at Case SOM, Spring 2005 Total SOMMaleFemale Postdoc Scholar Postdoc Fellow Research Associate* Senior Research Associate* Many are planning independent careers

Postdocs are at a critical juncture in training productive self-reliant about to embark on independent careers Often write a grant to seek financial support and recognition for their research

Why do you want a mentored grant? 1.Makes the relationship with the PI explicit 2.Benefits associated with grant 3.Looks good on your resume 4.Great learning experience 5.Not ready for the R01…

Where do you start? Communicate your PI, potential mentors/committee your chairperson the Office of Research Are you ready? pilot data time to focus appointment status deadlines Do you qualify? Not every Institute has these mechanisms Restricted to US citizens, permanent residents

The F32 NRSA individuals seeking posdoctoral research training in the basic and clinical sciences F32->RO1 set stipend scale and supplement

The F32 NRSA February 4, 2005 Stipends for Kirschstein-NRSA awards 2005 Postdoctoral Years of Experience: 0 $ 35,568 1 $ 37,476 2 $ 41,796 3 $ 43,428 4 $ 45,048 5 $ 46,992 6 $ 48,852 7 or more$ 51,036 Program announcements Institutional Allowance $5,500 Research supplies, health insurance, travel to mtgs

2002 Number number total cost success reviewed awarded awarded 1000s rate* MD202914,60245 PHD1, , all1, , Percentage that receive funding in a year (a resubmission is only counted the first time) The F32 NRSA is a reasonable goal: Success rates on Individual Postdoc Fellowship applications

Prepare the Application: read the instructions!! start early, seek internal reviewers a.Candidate (grades, GREs, etc) a.US citizen or permanent resident b.Doctoral degree (many ok) b.Sponsor and Training Environment c.Research Proposal a.Up to 3 yrs c.Training Potential d.Vertebrate Animals, Human Subjects etc. e.3 times per year, usu Feb1, June1, Oct 1 The A1 or A2. You may have to resubmit…

The F32 NRSA success is about 30%

Postdoctoral trainees are funded by many Institutes

1F30NS Assistive Device Control With Brain Surface Signals 5F30ES Initiation of Experimental Colitis by Commensal Flora 1F31HD Upper Extremity Control Using Reinforcement Learning 1F31MH Molecular Genetics of the Serotonin System 1F31NR Dance and Physical Activity in African American Women 5F31HD PREDOCTORAL FELLOWSHIP FOR STUDENTS WITH DISABILITIES 1F31MH ERK2 Specific Function of the CNS 5F31NR Kangaroo Care Effects on post/cath stabilization 1F32GM Creation of designer biogenic amine receptors 1F32AG A1Mechanisms of Abeta-Stimulated ROS in Microglia 5F32EB Group Theory Applied to rf Coil Design Predoctoral (Graduate Students!) Postdoctoral Case has few F awards

Grantwriting Resources Grantpersonship: An Instruction Manual NIMH Grant Application Process FASEB Grantsmanship Training Program Grant Application Writer’s Handbook, Reif-Lehrer

The K08 For clinically trained persons to pursue research careers in basic or clinical sciences. Must apply within 3 years of clinical Training (residency +1 year of clinical fellowship) Mentored Clinical Scientist Development Award K08->K02-> R01 up to $85,000 salary up to $50,000 costs per year up to five years, non-renewable

The K08 Prepare the Application: read the instructions!! a.Candidate b.Research Plan c.Career Development Plan/ Training Plan d.Environment/ Institutional support e.Mentor* f.Vertebrate Animals, Human Subjects etc. g.The A1 or A2. You may have to resubmit… h.(The summary statement)

The K08 1.Candidate** 2.Basic Science Mentor/co Mentor: 1.Good working relationship 2.Often funded by NIH 3.Expert in this area 4.Experienced trainer **some Institutes require faculty appointment (eg Instructor)

The K08 3. Career Development Plan (very important) Focused and relevant New techniques, new area, could be funded Present at meetings, review grants, external courses Update didactics Create an oversight committee familiar with research, career goals, meet six mos for feedback 4. Research Plan Provide preliminary data to support rationale, approach. Focus! Include study of Research Ethics, animals etc.

The K08 See supplementary info at each institute Insure protected time -Do not assume that 75% means anything except 75% of your total working hours -These estimates are carefully reviewed essential that your chair state this not contingent on receipt of the grant -50% Neurosurgery

What happens to your application after it leaves the mailbox? Scientific Review Group in Center for Scientific Review Study section review supplements Scores and percentiles Summary sheet

Inside the NIH Grant Review Process 39 min video NIH Center for Scientific Review Includes R01/K08/ R03 Download proposals View the video on the web Helpful Hints for an NLHBI K08 Application

1K08HL A1Medullary GABAergic Neurons in Neonatal Reflex Apnea 5K08AI CD8+ T CELLS AND MYCOPLASMA TUBERCULOSIS 5K08CA ERBB2 KINASE SIGNALING IN COLON CARCINOGENESIS 5K08DK The Role of TGF-alpha in the Pathogenesis of ARPKD 5K08DK QUANTITATIVE EXPRESSION LIBRARIES TO IDENTIFY ESRD GENES 5K08MH Youth Subjective Experience of Psychotropic Treatment 5K08HL PULMONARY IMMUNE DEFENCES AGAINST M. BOVIS-BCG INFECTION 5K08AI Innate immune responses in lymphatic filariasis 1K08HD Metabolic Requirements for Oogenesis and Embryogenesis 5K08AI Immunologic Studies of Endemic Burkitt's Lymphoma 5K08NS Systemic perinatal insults disrupt neurodevelopment 5K08NS The Role of PPAR Agonists in Inflammation and stroke K08 awards at Case