FORMATS OF NIH APPLICATIONS

Acknowledgment James S. Panagis, MD, MPH Director, Orthopaedics Program NIAMS, NIH, DHHS 6701 Democracy Boulevard, #800 Bethesda, MD 20892 (P) 301-594-5055 (F) 301-480-4543 jp149d@nih.gov

NIH 27 Institutes and Centers Budgets (FY 2005): NIH = ~$28 Billion NIAMS = ~$511 Million > 70,000 applications in FY 2004

Types of Applications Unsolicited Solicited Program Announcement (PA) Request for Applications (RFA) Request for Contracts (RFC)

NIH Receipt, Review & Award Cycles Cycle I Cycle II Cycle III All New & Competing Applications February 1 June 1 October 1 Revised Proposals March 1 July 1 November 1 Scientific Review June-July Oct-Nov Feb-March Advisory Council Sep-Oct Jan-Feb May-June Earliest Start December April July

Funding Mechanisms Training: F 31, 32, 33 Career Development: K 01, 02, 08, 22, 23, 24, 25 P 01 P 30, 50, 60 Research: R 01, 03, 15, 21, 37 R 41, 42, 43, 44 T 32 U 01

Career Timeline & NIH Mechanisms Medical School Residency Fellowship Junior Faculty Career T32 F32 K01, K08, K22, K23, R03, R21 R01, R21, K24

What is the Right Mechanism? Your training & experience What you need What you would like to do (time & amount)

Career Development Award “K” Awards

Mentored Research Scientist Development Award K01 http://grants.nih.gov/grants/guide/pa-files/PA-00-019.html

K01 Purpose is to develop outstanding scientists 3 – 5 yrs of supervised research experience 75 % effort Ineligible if prior R01, R29, K(01,07,23), P(01,50) Salary: Salary determined by I/C NIAMS=$75,000)

K01 Research Dev. Support: i.e., tuition, fees & research support. Amount varies (NIAMS = $20,000) Facilities & Admin costs: Fixed at 8% Mentor should have independent research support (mentor is not salaried) Standard receipt dates

Mentored Clinician Scientist Development Award K08 http://grants.nih.gov/grants/guide/pa-files/PA-00-003.html

K08 Purpose is to develop clinical research scientists Similar format/regulations to K01 52.3% success rate

NIAMS Career Transition Award K22 http://www.niams.nih.gov/rtac/funding/grants/pa/par_02_056.pdf

K22 Provides training within a NIAMS intramural lab followed by support in an extramural institution Ineligible if prior R01, R29, SBIR/STTR, P01, P50, K08 Provides up to $150,000/YR for all years

K22 Intramural (Phase I): Salary based upon training &experience. Extramural (Phase II): Salary up to $75,000. Can be supplemented. 75% effort. Up to $75,000 for research supplies. F & A: 8% Standard receipt dates 40.2 % success rate

Mentored Patient-Oriented Research Career Development Award K23 http://grants.nih.gov/grants/guide/pa-files/PA-00-004.html

K23 Purpose is to develop clinical researchers 3 – 5 yrs of support; 75% effort Same eligibility as the other K’s Salary : Varies by I/C. May be supplemented (NIAMS = $75,000) Res. Development Support: Up to $25,000 F & A: 8%

K23 Mentors should have independent research support Can not be salaried. Standard receipt dates 46.6 % success rate

Mentored Quantitative Research Career Development Award K25 http://grants.nih.gov/grants/guide/pa-files/PA-02-127.html

K25 Purpose is to foster interdisciplinary collaboration in biomedical research by supporting career development experiences for scientists with quantitative and engineering backgrounds 3-5 YRS of support 75% effort Similar format/regulations as other Ks

NIAMS Small Grant Award for New Investigators http://www.niams.nih.gov/rtac/funding/grants/pa/par_04_002.pdf

R03 Funding for pilot/preliminary data Ineligible if previous/current large mechanism support, or NIAMS R21 Receipt dates: 2/24/05, 6/24/05, 10/24/05 Up to 3 YRS of support Up to $50,000 direct costs/YR Limited to 2 small grant awards/career Lower success rate due to # of apps

Exploratory/Developmental Research Grant

R21 Appropriate for early stages of research that are high risk because of possible failure, but if successful, may be of significant benefit 2 YRS of support; $275,000 split over the 2 yrs

R21 Program Announcements PA-03-058: Exploratory/Developmental (R21) Bioengineering Research Grant (EBRG) http://www.niams.nih.gov/rtac/funding/grants/pa/pa_03_058.pdf PA-03-107: NIH Exploratory/Developmental Research Grant Award (R21) http://www.niams.nih.gov/rtac/funding/grants/pa/pa_03_107.pdf

Shorter Duration R01 Prove feasibility, setting stage for what to follow in a competing continuation Suggest 3 years Avoids being “overly ambitious” in an R03, or if limited preliminary data, “high risk” for a longer duration R01

NIH Loan Repayment Program for Clinical Researchers Purpose: To recruit & retain clinical investigators Re-pays up to $35,000/YR of educational loan expenses for each YR of obligated service Also pays 39% of loan repayment to IRS Must agree to engage in clinical research a minimum of 2 years http://www.lrp.nih.gov

Tips Contact NIH Program Officer (PO) Read application instructions carefully Focus on perfecting the abstract & specific aims Communicate clearly & thoroughly Allow time for a thorough editing & proofreading Have knowledgeable colleagues review application Send in supplemental progress materials, papers Speak with NIH PO post-review Be prepared to revise in response to critique

BE PERSISTENT

Resources NIAMS Homepage: http://www.niams.nih.gov NIH Grants Page: http://grants1.nih.gov/grants/oer.htm “Welcome Wagon”: http://grants1.nih.gov/grants/funding/welcomewagon.htm “Getting Started at the NIH”: http://grants1.nih.gov/grants/useful_links.htm “Grant Writing Tips”: http://grants1.nih.gov/grants/grant_tips.htm

Resources: Tutorials How to Write a Grant Application: www.niaid.nih.gov/ncn/grants/write/write.pdf Advice on Research Training & Career Awards: www.niaid.nih.gov/ncn/grants/advice/advice.pdf How to Write an Application Involving Animals: www.niaid.nih.gov/ncn/clinical/researchanimals/tutorial/researchanimals.pdf How to Write a Human Subjects Application: www.niaid.nih.gov/ncn/clinical/humansubjects/humansubjects.pdf Annotated R01 Grant Application: www.niaid.nih.gov/ncn/grants/app/default.htm