IMMUNE RESPONSE IMAGES

Monoclonal antibodies A graphical representation of monoclonal antibodies binding to antigens on a cell surface. A population of monoclonal antibodies targets a specific antigen. They are derived from the same cell and grown clonally (mono-clonal). In this image the antigens are depicted as gold rings and the binding site of the monoclonal antibodies are gold clefts in the Y-shaped antibody structure. Credit: Anna Tanczos/Wellcome Images

Frog IgM antibodies BIGPICTUREEDUCATION.COM Two frog IgM antibody molecules. Each molecule contains six Y-shaped subunits analogous to IgG molecules that are held together in a star shape. Each IgM is approximately 30 nanometres in diameter. Credit: R Dourmashkin/Wellcome Images BIGPICTUREEDUCATION.COM

Lymphocyte with red blood cells Colour-enhanced image of a small lymphocyte surrounded by a number of red blood cells. Credit: University of Edinburgh/Wellcome Images BIGPICTUREEDUCATION.COM

Neutrophils in peripheral blood smear Two neutrophils are surrounded by red blood cells. Neutrophils are one type of leukocyte (white blood cell) and have a multi-lobed nucleus. Credit: Spike Walker/Wellcome Images BIGPICTUREEDUCATION.COM

Fungal elements engulfed by neutrophils Colour-enhaced transmission electron micrograph showing fungal bodies (blue) being engulfed by leukocytes (yellow) in the cornea. Credit: Rob Young/Wellcome Images BIGPICTUREEDUCATION.COM

Phagocytotic vesicle and lysosomes inside a macrophage Macrophage from a human tonsil containing a phagocytic vesicle (pink) and lysosomes (dark red). The lysosomes degrade the ingested material by subjecting it to strong chemical and enzymatic attack. Credit: University of Edinburgh/Wellcome Images BIGPICTUREEDUCATION.COM

Eosinophil among red blood cells Micrograph showing red blood cells and an eosinphil. Eosinophils are granulocytes, white blood cells (leukocytes) with highly granular cytoplasm and a multilobed nucleus. They defend against parasites and are phagocytic. Credit: Spike Walker/Wellcome Images   BIGPICTUREEDUCATION.COM

Mast cell showing histamine granules Colour-enhanced transmission electron microscope image of a mast cell full of histamine granules (pink). Histamine is released as part of an allergic reaction.  Credit: University of Edinburgh/Wellcome Images BIGPICTUREEDUCATION.COM

Complement-induced pores in a cell Complement-induced pores in a red blood cell membrane. This blood was taken from a patient with paroxysmal nocturnal haemoglobinuria, where red blood cells are abnormally sensitive to lysis (destruction) by the complement system. Credit: R Dourmashkin/Wellcome Images BIGPICTUREEDUCATION.COM

Microneedle vaccine patch The image shows an array of microneedles, micron-scale needles, formed out of a biodegradable polymer. Researchers have shown these materials to be useful in painlessly and safely penetrating the outer layers of the skin, to deliver vaccines and other medicines. Credit: Peter DeMuth/Wellcome Images BIGPICTUREEDUCATION.COM

Reusing our images Images and illustrations All images, unless otherwise indicated, are from Wellcome Images. Contemporary images are free to use for educational purposes (they have a Creative Commons Attribution, Non-commercial, No derivatives licence). Please make sure you credit them as we have done on the site; the format is ‘Creator’s name, Wellcome Images’. Historical images have a Creative Commons Attribution 4.0 licence: they’re free to use in any way as long as they’re credited to ‘Wellcome Library, London’. Flickr images that we have used have a Creative Commons Attribution 4.0 licence, meaning we – and you – are free to use in any way as long as the original owner is credited. Cartoon illustrations are © Glen McBeth. We commission Glen to produce these illustrations for ‘Big Picture’. He is happy for teachers and students to use his illustrations in a classroom setting, but for other uses, permission must be sought. We source other images from photo libraries such as Science Photo Library, Corbis and iStock and will acknowledge in an image’s credit if this is the case. We do not hold the rights to these images, so if you would like to reproduce them, you will need to contact the photo library directly. If you’re unsure about whether you can use or republish a piece of content, just get in touch with us at bigpicture@wellcome.ac.uk.