Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD Thomas L. Lentz, MD No part of this image collection may be distributed.

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Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD Thomas L. Lentz, MD No part of this image collection may be distributed outside of the Yale University Intranet.

Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New York, Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins, Baltimore, Kerr, J. B. Atlas of Functional Histology. Mosby, London, Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning electron microscopy. W. H. Freeman, San Francisco, Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York, Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo. Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill Livingstone, Edinburgh, Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson, Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz. Web Resources Cushing Library Educational Software/Cell Biology/Several Histology Resources Acknowledgements Sources of Micrographs, Diagrams and Figures

Lymphoid System Laboratory

Plasma Cell

Peyer’s Patches (Lymphoid Follicles) in Small Gut Germinal Center (GC)

Organized GALT/MALT Diffuse GALT in gut lamina propria GALT: gut-associated lymphoid tissue MALT: mucosa-associated lymphoid tissue

Peyer’s Patch Lymphoid follicle Germinal center

Lymph Node Cortex Medulla Secondary follicles Subcapsular sinus Efferent lymphatics Hilus Medullary cords Afferent lymphatic

Medulla Cortex Germinal centers Lymph Node

Subcapsular sinus Afferent lymphatic with valve (V)

Secondary Follicle Germinal center: B cell proliferation and maturation Mantle of resting and memory B cells

Reticulin stain of lymph node

Palatine tonsil

Thymus Cortex Medulla

Thymus Cortex (developing T cells) Medulla

Thymic medulla with Hassall’s corpuscles

Hassall’s corpuscles

Development of T cells in Thymus

Spleen

Red pulp White pulp PALS Trabeular artery

B cell mantle PALS (T cells) GC Central arteriole Spleen

Spleen Red Pulp Endothelial cells Venous sinus

Direction of blood flow in spleen

Organization of the spleen

Some Pathology

Benign Reactive Lymph Node

Which cells are responding?

Adenocarcinoma Metastases to Lymph Node How did the tumor cells get to this location?

Adenocarcinoma Metastases to Lymph Node How did the tumor cells get to this location?