Discussion Sessions Facilitated by The LifeLine Group Slides and Materials Copyright Protected

Session A ComET™ : Near field component (Lead: Chris Chaisson/Paul Price) (Lead: Chris Chaisson/Paul Price) Focus Issues: 1.Opportunities for Improving Accuracy of Metrics used to characterize Sentinel Products. Replacing defaults and assumptions with data relevant to the sentinel product for any given compound. 2.Possible sources for data. Data evaluation and application: sources for expertise. 3.Incentive for data donors…reaching the informed audience and having the data provided to ComET™ 4.Options for technical improvement.

Key Points Review--What is a sentinel product Review--What is a sentinel product Even if “fully stocked with detailed info”, why ComET IS NOT a full risk assessment model. Even if “fully stocked with detailed info”, why ComET IS NOT a full risk assessment model. studies by trade associations studies by trade associations Helpful to indicate what the sentinel products are and what routes, etc. (by chemical)…improve search and summary Helpful to indicate what the sentinel products are and what routes, etc. (by chemical)…improve search and summary

Use other models instead of EASE…use more than one model to apply back to ComET Use other models instead of EASE…use more than one model to apply back to ComET CTFA about to release info. CTFA about to release info. Put out help as reference of use metrics as compared to use instructions on products. Compare our assumptions to the actual use instructions on these kinds of products. -- another element to consider for groundtruthing Put out help as reference of use metrics as compared to use instructions on products. Compare our assumptions to the actual use instructions on these kinds of products. -- another element to consider for groundtruthing

Many of the substances have been through the evaluations processes in other countries Agencies…find info in those data bases Many of the substances have been through the evaluations processes in other countries Agencies…find info in those data bases Swimmer exposures—in addition to algorithms, SWIM model…data underlie the problem of underlying toxic entity…eg, chlorophorm…transformation to the toxic component…to some extent ComET does not address the transformation issue. Swimmer exposures—in addition to algorithms, SWIM model…data underlie the problem of underlying toxic entity…eg, chlorophorm…transformation to the toxic component…to some extent ComET does not address the transformation issue.

Note that regulations and defaults must be applicable to Canadian citizens and the HC default values Note that regulations and defaults must be applicable to Canadian citizens and the HC default values Types of information—what kind of documentation is required? Types of information—what kind of documentation is required? –Publicly released,  Marketing materials, MSDS, public info. As we collect library of sentinel products, are there others not covered? Bring these to our attention. The sooner we can get to the list of sentinel products, the sooner we will get data for the metrics on these sentinel products. As we collect library of sentinel products, are there others not covered? Bring these to our attention. The sooner we can get to the list of sentinel products, the sooner we will get data for the metrics on these sentinel products. There will be advantage to get full list of sentinel products so industry can turn their attention to getting the data we need. Can we do some kind of scoping exercise. There will be advantage to get full list of sentinel products so industry can turn their attention to getting the data we need. Can we do some kind of scoping exercise.

In giving equal weight to the hazard component…where there is high hazard, maybe we should be more careful and specific about the exposure component—maybe in those cases, underestimating exposure would be unwise. For the very toxic substances, the crude exposure tools might need upgrading. In giving equal weight to the hazard component…where there is high hazard, maybe we should be more careful and specific about the exposure component—maybe in those cases, underestimating exposure would be unwise. For the very toxic substances, the crude exposure tools might need upgrading. Level of refinement of exposure will be dependent on level of hazard. Level of refinement of exposure will be dependent on level of hazard. One significant figure should be used. One significant figure should be used.

Careful!! Misuse of these numbers can be expected. Careful!! Misuse of these numbers can be expected. Code of practice should go with this. Is there another term for “exposure estimate”? Code of practice should go with this. Is there another term for “exposure estimate”? Ground truthing exercise—can we take some of these instances and see if they are plausible… Ground truthing exercise—can we take some of these instances and see if they are plausible… Ground truthing exercise—would the same relative ranking exist…not if the exposure that is predicted would actually exist. So the relative ranking might be do-able. Ground truthing exercise—would the same relative ranking exist…not if the exposure that is predicted would actually exist. So the relative ranking might be do-able.

Frame formulas in the poison control center (Lori Fix)…ingredients in products…range of what is typical. Frame formulas in the poison control center (Lori Fix)…ingredients in products…range of what is typical. Contract manufacturers make things for many clients. Might be able to get this info…CCL for example. Contract manufacturers make things for many clients. Might be able to get this info…CCL for example. These sources of information can only be used if the data are not CBI. Transparency will be a key point. These sources of information can only be used if the data are not CBI. Transparency will be a key point. Lori Fix will put together lists of urls. Lori Fix will put together lists of urls. Old formulas—may be “prospective” and may not be commercially viable—want current formulas that are really being sold. Old formulas—may be “prospective” and may not be commercially viable—want current formulas that are really being sold.

Which chemicals/sentinel use products are of interest to HC? HC is going as fast as possible…remaining chemicals will be subdivided. There will be generic issues such as Which chemicals/sentinel use products are of interest to HC? HC is going as fast as possible…remaining chemicals will be subdivided. There will be generic issues such as –UVCBs –Polymers/monomer residues May be helpful to highlight “what’s new” in the new releases. May be helpful to highlight “what’s new” in the new releases. Solubility, and other parameters 1 vs Solubility, and other parameters 1 vs is there a way to refine that ? Organics? Inorganics? Suggestions? Rules to be defined by properties which may be readily available for all substances?

Are we using high end use scenarios? Highest? We use plausible high exposure product AND plausible high use metrics. Are we using high end use scenarios? Highest? We use plausible high exposure product AND plausible high use metrics.