Bcl-2 and its Role in Cancer. Mitochondria in the Cell

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Presentation transcript:

Bcl-2 and its Role in Cancer

Mitochondria in the Cell

Cytochrome C’s Dual Functionality Protein that carries electrons in electron transport chain between mitochondrial membranes BUT released into cytosol, triggers apoptosis Cytochrome_C.png

Bcl-2 family – apoptosis regulators ma_htmlcourse/page3

Stress signal (DNA damage, heat shock) Pro-apoptotic members activated Cytochrome c release via MOMP Cytochrome c complexes with ATP and Apaf-1 (enzyme) Caspase-9 activated, then forms apoptosome with previous complex Caspase cascade to apoptosis Apoptosis Pathway

Viable, but smaller Half die by 6 weeks Smaller kidneys Skeletal development Immune failure Bcl-2 Knockout Mice

tbn3.gstatic.com/images?q=tbn:ANd9GcTkoz4iPsXeDUTi1dbV1wzIQsD8sDB7HqkRJaxih9U4 UWe9Cusd-A Non- Hodgkin Lymphoma

Bcl-2 Translocations Found in Cancer

htmlcourse/page3 Overexpression of Bcl-2 on the Outer Membrane of Mitochondria

Inhibiting Bcl-2

m4s3c_3.jpg Potential Therapeutic Undergoing Clinical Trials

Sources / /pdf/iep_79.pdf ngcancer/targetedtherapies/lymphoma_htmlcour se /S

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