DNA Damage Regulates Alternative Splicing through Inhibition of RNA Polymerase II Elongation Manuel J. Muñoz, M. Soledad Pérez Santangelo, Maria P. Paronetto,

Slides:



Advertisements
Similar presentations
Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low- Complexity Domains Ilmin Kwon, Masato Kato, Siheng Xiang, Leeju Wu,
Advertisements

The Bacterial DnaC Helicase Loader Is a DnaB Ring Breaker Ernesto Arias-Palomo, Valerie L. O’Shea, Iris V. Hood, James M. Berger Cell Volume 153, Issue.
Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.
SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.
The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin Cell Volume 144, Issue 1, Pages.
Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding J. Winter, M. Ilbert, P.C.F. Graf, D. Özcelik, U. Jakob Cell Volume 135, Issue.
Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding Aleksandra Helwak, Grzegorz Kudla, Tatiana Dudnakova, David Tollervey.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Treatment of Obesity with Celastrol
RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3- Kinase Isoforms Ralph Fritsch, Inge de Krijger, Kornelia Fritsch, Roger.
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.
Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm Jianbin Wang, H. Christina Fan, Barry Behr, Stephen.
UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.
Sulfur Amino Acids Regulate Translational Capacity and Metabolic Homeostasis through Modulation of tRNA Thiolation Sunil Laxman, Benjamin M. Sutter, Xi.
Nucleation and Transport Organize Microtubules in Metaphase Spindles Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel J. Needleman Cell Volume 149, Issue.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.
Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.
Structurally Distinct Ca2+ Signaling Domains of Sperm Flagella Orchestrate Tyrosine Phosphorylation and Motility Jean-Ju Chung, Sang-Hee Shim, Robert A.
Predicting C4 Photosynthesis Evolution: Modular, Individually Adaptive Steps on a Mount Fuji Fitness Landscape David Heckmann, Stefanie Schulze, Alisandra.
The Monarch Butterfly Genome Yields Insights into Long-Distance Migration Shuai Zhan, Christine Merlin, Jeffrey L. Boore, Steven M. Reppert Cell Volume.
Dynein Anchors Its mRNA Cargo after Apical Transport in the Drosophila Blastoderm Embryo Renald Delanoue, Ilan Davis Cell Volume 122, Issue 1, Pages
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell
Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,
The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis Eran Elinav, Till Strowig, Andrew L. Kau, Jorge Henao-Mejia, Christoph A. Thaiss,
SRC-3 Coactivator Functional Lifetime Is Regulated by a Phospho-Dependent Ubiquitin Time Clock Ray-Chang Wu, Qin Feng, David M. Lonard, Bert W. O'Malley.
The Search for Antiaging Interventions: From Elixirs to Fasting Regimens Rafael de Cabo, Didac Carmona-Gutierrez, Michel Bernier, Michael N. Hall, Frank.
Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:
Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model Jennifer S. Pfingsten, Karen J. Goodrich, Cornelius Taabazuing,
Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits Yiming Chen, Yen-Chu Lin, Tzu-Wei Kuo, Zachary A. Knight Cell Volume 160, Issue 5,
SSB Functions as a Sliding Platform that Migrates on DNA via Reptation Ruobo Zhou, Alexander G. Kozlov, Rahul Roy, Jichuan Zhang, Sergey Korolev, Timothy.
Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel
Volume 1, Issue 1, Pages (June 2007)
CoSMoS Unravels Mysteries of Transcription Initiation
Unweaving the Autism Spectrum
Linking Protein and RNA Function within the Same Gene
A New Twist on Transcriptional Bursting
Mapping Human Epigenomes
Redefining Clinical Trials: The Age of Personalized Medicine
The Proteasome: Not Just Degrading Anymore
Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses
Volume 154, Issue 1, Pages (July 2013)
In This Issue Cell Volume 158, Issue 5, (August 2014)
Volume 152, Issue 1, (January 2013)
Volume 130, Issue 6, (September 2007)
Volume 64, Issue 3, Pages (November 2016)
Need for Speed: Mechanical Regulation of a Replicative Helicase
Proteins Kinases: Chromatin-Associated Enzymes?
How Slow RNA Polymerase II Elongation Favors Alternative Exon Skipping
Easy Stress Relief by EZH2
Volume 143, Issue 6, (December 2010)
A Movie of RNA Polymerase II Transcription
Making the Most from Changes in Life
Learning from the Uncontrollable
Poised RNA Polymerase II Gives Pause for Thought
Volume 163, Issue 4, (November 2015)
Volume 61, Issue 2, Pages (January 2016)
Volume 163, Issue 2, (October 2015)
Volume 134, Issue 6, (September 2008)
David Hubel and Torsten Wiesel
In This Issue Cell Volume 145, Issue 3, (April 2011)
Volume 148, Issue 1, (January 2012)
Targeting Protein Stability with a Small Molecule
Presentation transcript:

DNA Damage Regulates Alternative Splicing through Inhibition of RNA Polymerase II Elongation Manuel J. Muñoz, M. Soledad Pérez Santangelo, Maria P. Paronetto, Manuel de la Mata, Federico Pelisch, Stéphanie Boireau, Kira Glover-Cutter, Claudia Ben-Dov, Matías Blaustein, Juan J. Lozano, Gregory Bird, David Bentley, Edouard Bertrand, Alberto R. Kornblihtt Cell Volume 137, Issue 4, Pages (May 2009) DOI: /j.cell Copyright © 2009 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 1 Cell , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 2 Cell , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 3 Cell , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 4 Cell , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 5 Cell , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 6 Cell , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions Terms and Conditions

Figure 7 Cell , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions Terms and Conditions