2. Synthetic Utilization of pentafulvenes

2. Development of Synthetic Methodologies towards Fused Cyclooctanoids NIIST Some of the Biologically active cyclooctanoids Developed a Novel Methodology for the synthesis of 5-8 fused Cyclooctanoids  Developed a Novel Methodology for the synthesis of 5-8 fused Cyclooctanoids Tet. Lett Tet. Lett. 2005, 46,

Utilization of the Developed Synthetic Methodology NIIST Tet. Lett Tet. Lett. 2005, 46, Tetrahedron Tetrahedron, 2006, Tetrahedron, Tetrahedron, 2006, 62, 12345; Synthesis Synthesis, 2006,11, Eur. J. Org. Chem., 5847 Eur. J. Org. Chem. 2007, 5847

 Novel route to eleven membered rings and spirocyclic cyclooctanoids NIIST ”, “Heterocycles via Pyrylium and Pyridinium Betaines”, K. V. Radhakrishnan, Topics in Heterocyclic Chemistry, Vol. Synthesis of Heterocycles via Cycloadditions, 13, 2008, pages , Springer. Eur. J. Org. Chem., , 5847 Synthesis, 2008, 13, 2134

NIIST 3. Synthetic Carbohydrate Chemistry  1,2-Orthoesters- Important Intermediates in Synthetic Carbohydrate Chemistry For eg: n-Pentenyl Orthoesters as Glycoside Donors  Design, Synthesis and Host-Guest Evaluation of Neoglycoconjugates Ionic liquid [bmim]PF 6 Mediated Synthesis of 1,2-Orthoesters of Carbohydrates  We have developed a facile and environmentally benign method for the synthesis of 1,2- orthoesters of carbohydrates and Glycosidation reactions of synthesis of 1,2- orthoesters of carbohydrates and Glycosidation reactions of NPOE in ionic liquid [bmim]PF 6. NPOE in ionic liquid [bmim]PF 6.  The method is much simpler and the solvent can be reused several times Synlett, 2005, 6, 997 Bull. Chem. Soc. Jpn. 2007, 553.

Synthesis and Study of Carbohydrate Appended Mutivalent ligands  Synthesis of higher order glycoconjugates as probes to define the molecular nature of carbohydrate-receptor interactions  Interaction of metal ions with carbohydrates is an important element for biochemical processes  Metal complexes involving carbohydrates clarify many functions of carbohydrates in natural systems Carbohydrates as Scaffolds by attaching a chelating ligand for cation and anion binding

Able to encapsulate guest molecules Synthesis and study of Carbohydrate-coated Nanocapsules Target selective nanocarriers Labelling specific protein Sensing of a range of pathogens. Vesicles Nanorods NIIST  Photochromic nanocapsules  Multivalent nanoscaffolds for selective interactions